<h3>Purpose</h3> Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator; these mutations impair chloride conduction, which reduces water on the cell surface and leads to accumulation of viscous mucous in the lungs. Accumulated mucous drives chronic infections, bronchiectasis, and eventually, respiratory failure requiring lung transplant (LT). We aimed to study the impact of gender and age at the time of LT on long-term survival of patients with CF. <h3>Methods</h3> Lung transplant recipients with CF who received post-LT care at our center between July 1, 2007 and April 30, 2021 were included. Primary outcome was death or redo LT. Cox proportional hazard analysis, Kaplan-Meier method, and log-rank tests were used for data analysis. <h3>Results</h3> A total of 59 LT recipients met inclusion criteria. The median age at primary LT was 28 (22, 36) years, 36 (61%) patients were ≥25 years old, and 30 (51%) were male. At the end of the study period, 21 (35.6%) LT recipients died and 17 (28.8%) required redo LT with a median lung allograft survival of 33.4 (16.1, 66.4) months. The remaining 21 patients (36%) were alive at a median of 68 (28, 112) months after primary LT. The risk of death trended lower and the probability of survival trended higher in male patients than in female patients (HR: 0.487 [95% CI: 0.221-1.075], p=0.075 and 66.7% vs 44.8%, p=0.069, respectively, Figure 1A). Compared to age <25 years at LT, age ≥25 years was associated with a lower risk of death and an increased probability of survival (HR: 0.466 [95% CI: 0.215-1.007], p=0.052 and 63.9% vs 43.5%, p=0.047, respectively, Figure 1B). <h3>Conclusion</h3> In our study, LT recipients with CF ≥25 years at LT had significantly higher survival than younger patients, and survival trended higher for male recipients than female recipients. These results identify an "at-risk" population of LT recipients who may warrant closer attention after LT. Large multicenter trials with adequate power are needed.