Aim: To ascertain the quality of life in patients undergoing PTBD for palliation of surgical obstructive jaundice (SOJ) in inoperable cases of carcinoma gall bladder with jaundice. Method: From January 2016 to November 2017, 32 patients of inoperable carcinoma gallbladder with jaundice underwent PTBD with palliative intent. 18 such Patients followed up and were assessed by FACT-HEP and EORTC QLQ BIL 21 questionnaire pre-procedure, post-procedure, and one month post-procedure. Thereafter patients were followed up monthly. Patients unwilling to enroll for the study or those lost to follow up were excluded. Results: Mean age 54.17 yrs , M:F ratio = 1:1, type of PTBD, complications, procedure related mortality, cost of procedure, mean follow up was recorded. All the data along with the Questionnaire split analysis was done using the SPSS version 23. FACT HEP- factors that showed improvement - physical, social/family, emotional ,functional well being (p < 0.000) . Additional concerns related to symptoms also showed significant improvement (p < 0.000). PTBD tube related problems did not significantly affect QOL (p < 0.000). EORTC QLQ BIL21 - Improvement was seen in Eating symptom (p < 0.001), jaundice (p < 0.000), tiredness (p < 0.11), pain (p < 0.001), anxiety (p < 0.000) and tube related symptom also did not adversely alter the quality of life (p < 0.000). Conclusion: Even in a hopeless situation like inoperable gallbladder cancer with SOJ, although no survival benefit is seen by this palliative treatment, the QOL is significantly improved despite the procedure related complications and high cost of treatment.