Objective: To evaluate the effect of platelet-rich plasma and arthroscopic minimally invasive surgery treatment in patients with degenerative knee joint lesions. Methods: From July 2015 to July 2022, 80 patients with degenerative knee joint lesions were selected and randomly divided into two groups. Group A received platelet-rich plasma and minimally invasive arthroscopic surgery treatment while group B received only minimally invasive arthroscopic surgery treatment. The treatment efficacy, visual analog scores (VAS), knee osteoarthritis severity index (ISOA), knee function scores (KSS), and Lysholm knee scores were compared. Results: The treatment efficacy in group A was higher than that in group B (P < 0.05); at 3 and 6 months after surgery, the VAS and ISOA scores of group A were lower than those of group B (P < 0.05), while the KSS and Lysholm scores of group A were higher than those of group B (P < 0.05); the treatment satisfaction in group A was higher than that in group B (P < 0.05). Conclusion: Patients with knee joint degeneration receiving platelet-rich plasma and minimally invasive arthroscopic surgery treatment can restore knee joint function and reduce local pain,which is efficient and feasible for clinical application.