You have accessJournal of UrologyCME1 Apr 2023MP28-09 PROGNOSTIC VALUE OF AUTOLOGOUS CYTOKINE-INDUCED KILLER CELLS AND DENDRITIC CELLS (DC-CIKS) COMBINATION IMMUNOTHERAPY IN PATIENTS WITH RENAL CELL CARCINOMA Peng Ge, Hailong Li, Zijie Liu, Zixiang Li, Li Ding, Yang Zhang, Huizhong Li, Junqi Wang, and Junnian Zheng Peng GePeng Ge More articles by this author , Hailong LiHailong Li More articles by this author , Zijie LiuZijie Liu More articles by this author , Zixiang LiZixiang Li More articles by this author , Li DingLi Ding More articles by this author , Yang ZhangYang Zhang More articles by this author , Huizhong LiHuizhong Li More articles by this author , Junqi WangJunqi Wang More articles by this author , and Junnian ZhengJunnian Zheng More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003256.09AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: This study sought to evaluate the prognostic significance of autologous DC-CIK immunotherapy in patients with RCC and to construct and internally validate a nomogram model for predicting the overall survival of patients treated with DC-CIKs. Finally, a web-based interactive tool based on the final model was developed. METHODS: This study was approved by the ethical committee review board. From January 2009 to June 2015, patients who underwent surgery for RCC, including radical nephrectomy or partial nephrectomy, at our institution were enrolled and their clinicopathological data were retrospectively analyzed. RESULTS: Overall, 563 patients were included in the present study. 41.7% (235 cases) received DC-CIKs. The mean cycle count of the DC-CIKs was 4.1. There were no significant differences in the baseline characteristics between the patients who did not receive DC-CIKs and those who received any cycle of DC-CIKs, except for the histological subtype. The median follow-up time was 83 months (IQR: 57 - 105). During the study period, 83 (14.5%) patients died. In both the univariable and multivariable Cox analyses, the patients who received >4 cycles of DC-CIKs were significantly associated with a lower mortality (HR=0.355, 95% CI: 0.155 - 0.816, p=0.015, and HR=0.394, 95% CI: 0.170 - 0.913, p=0.030, respectively). A nomogram based on these five parameters (age, NLR, AJCC stage, histologic subtype, and cycle count of DC-CIKs) was developed to predict the 3-, 5-, 10-yr OS in the DC-CIKs cohort. Based on the final model, a web-based interactive tool was developed (https://dl0710.shinyapps.io/DC_CIKsur/). CONCLUSIONS: In the present study, we confirmed the clinical efficacy of the combination of autologous DC-CIKs in patients with RCC after radical nephrectomy or partial nephrectomy. Moreover, a higher cycle count of CIKs was associated with a superior outcome. To the best of our knowledge, our study included the largest cohort of patients with the longest follow-up on this topic to date, and is also the first study to develop a nomogram and web-based interactive tool for predicting the overall survival of patients treated with DC-CIKs, providing further evidence to support clinical decision-making. Source of Funding: This work was supported by the Opening Project of Key Laboratories in Jiangsu Provincial Universities(XZSYSKF2021003), the Six talent peaks project in Jiangsu Province (WSW-064), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(19KJB310001), the Post-doctoral Research Funding Project in Jiangsu Province (2021K447C) and the Xuzhou Leading Medical Talents Training Project (XWRCHT20210027) © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e373 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Peng Ge More articles by this author Hailong Li More articles by this author Zijie Liu More articles by this author Zixiang Li More articles by this author Li Ding More articles by this author Yang Zhang More articles by this author Huizhong Li More articles by this author Junqi Wang More articles by this author Junnian Zheng More articles by this author Expand All Advertisement PDF downloadLoading ...