The effects of structural anisotropy on dynamic yield and spallation damage of an AlSi10Mg alloy manufactured via laser powder bed fusion are investigated via plate impact experiments along the build direction (BD) and the transverse direction (TD). Free surface velocity histories are measured to deduce its dynamic mechanical properties. The as-received and postmortem samples are characterized with scanning electron microscopy, metallograpic microscopy, electron backscatter diffraction and synchrotron X-ray computed tomography. The Hugoniot elastic limit for loading along TD is about 40% higher than that along BD, given the initial 〈100〉∥BD texture. For spallation, voids prefer to nucleate at melt pool boundaries. Spall strength for loading along TD is about 18% higher than that along BD, as a result of higher critical stress for void nucleation and less nucleation sites due to the melt pool morphology. The damage evolution features are also correlated well with melt pool morphology and grain morphology within the pool interior, demonstrating the “ductile” interpool and “brittle” intrapool fracture modes for loading along BD and TD, respectively.