Lubrication and cooling in hard machining is an urgent and growing concern. The use of a suitable cooling lubrication condition is a crucial factor and has a great influence on the machining efficiency and the machined surface quality in hard machining. Among the proposed technological solutions, minimum quantity lubrication (MQL) using nano-cutting oils is a novel solution and its effectiveness has been proven for hard turning. This work aims to investigate the influence of MQL technological parameters using MoS2 nano-cutting oil including nanoparticle concentration, air pressure, and air flow rate on surface roughness and the resultant cutting force in hard turning using CBN inserts. Box-Behnken optimal experimental design and ANOVA analysis were used to study the influence of the input parameters and determine the optimal values. The results present the influence of the survey parameters and provide technological guides for specific objective functions for further sustainable studies on MQL hard turning using nano-cutting oil.