Surface Epithelial Tumors Of Ovary Research Articles

Immunohistochemical Study of CA 125 in Surface Epithelial Tumors of Ovary in Correlation with Serum Levels

Background:
 Ovarian carcinoma is the 4th leading cancer among women in India. Primary ovarian neoplasms exhibit a wide range of histopathological patterns and tumors with epithelial differentiation are most frequent. Among malignant tumors, most common histological type is serous adenocarcinoma whose diagnosis is established in advanced stages of disease in approximately 75% of patients.
 The most widely used tumor marker in ovarian cancer, often considered “gold standard” is Cancer Antigen125. Cancer Antigen 125 is a high molecular weight glycoprotein which is raised in approximately 90% of patients with advanced epithelial ovarian cancer.
 
 Methods:
 A 2 year prospective study included 81 cases of ovarian neoplasms with surface epithelial differentiation. The specimens were fixed in 10% formalin, routinely processed. Sections of 4-5 microns thickness were obtained from the paraffin block and stained with Hematoxylin & Eosin. The tumors were categorised according to WHO classification. Immunohistochemical analysis of Cancer Antigen 125 was done in all malignant & borderline tumors.
 
 Result:
 A total of 81 cases were studied. There were 15 cases with elevated serum Cancer Antigen 125 levels. Of these 8 showed positive tissue expression. The sensitivity of serum Cancer Antigen 125 was 68.75% & its specificity was 93.8%.
 
 Conclusion: 
 Serum Cancer Antigen 125 is elevated in ovarian tumors especially in malignant surface epithelial tumors & more commonly in serous cystadenocarcinoma. There was a good correlation between serum levels & tissue expression of Cancer Antigen 125.

Role of Her-2 Neu as Prognostic Indicator in Surface Epithelial Tumors of Ovary

Role of Her-2 Neu as Prognostic Indicator in Surface Epithelial Tumors of Ovary

Expression of p53 and CD34 in Surface Epithelial Tumors of Ovary

Ovarian cancer accounts for 3 % of all cancers in females (1) . Owing to diagnostic difficulty of ovarian cancers at early stage, most of them are diagnosed when they are at metastatic stage, thus they account for increased number of deaths occurring in women due to genital tract tumors. Ovarian Carcinomas are currently divided into Type I ( low grade) and Type II ( high grade ) tumours. (1) p53 and CD34 have been reported to play an important role in the progression of ovarian cancer. However, only few studies focus on their expression in benign surface epithelial tumors compared to malignant surface epithelial tumors and further low grade tumors compared to high grade tumors in the malignant category. Tumour angiogenesis, evaluated by CD34 expression as intratumoral microvessel density and CD34 intensity index could be an important predictor of the aggressive nature of high grade ovarian carcinoma. Overexpression of p53 in ovarian tumors of both low-grade and high-grade ovarian tumors has been found to be associated with poor prognosis in most but not all studies. (2) In present study, Mean microvessel density, CD34 intensity index and p53 proportion scoring of High grade tumors was statistically significantly higher than Low grade tumors (p value <0.05). Infact, immunohistochemical staining for p53 has been utilized as a surrogate marker for mutational analysis in the diagnostic workup of carcinomas of multiple sites including ovarian cancers. (3) Implication of p53 and CD34 in predicting the metastatic potential of ovarian surface epithelial carcinomas has to be further analysed with larger sample size.

Surface epithelial tumors of ovary - an analysis in a tertiary referral hospital

Background: Ovarian cancer accounts for 3% of all cancers in females. About 80% of these are benign, and they occur mostly in young women between 20 and 45 years. Borderline tumors occur at slightly older ages while incidence of malignant tumors increases with age, occurring predominantly in perimenopausal and postmenopausal women. About 190,000 new cases and 114,000 deaths from ovarian cancer are estimated to occur annually worldwide. The aim of the study was to fi nd the incidence of surface ovarian tumor in a tertiary referral centre. Materials and methods: This was a retrospective study carried out in the department of pathology, Manipal Teaching Hospital from January 2001 to December 2012. Specimens were received from the same and other hospitals. Records were retrieved from the departmental data bank and were analyzed. Results: : A total of 310 cases of ovarian tumors have been reported in the same period. Among them, 180 cases were of surface epithelial origin and out of which 24 cases had bilateral tumors. Benign tumors comprised of 148 cases, 6 were borderline and 44 were malignant. Among these, the commonest was serous cystadenoma (98 cases) and the least common was malignant Brenner (2 cases). Combined or mixed tumor was seen in 9 cases. Conclusion: : In our study surface epithelial tumors comprised 58% of all ovarian tumors. In both benign and malignant cases, serous tumor was the commonest followed by mucinous tumors. Journal of Pathology of Nepal (2013) Vol. 3, No.1, Issue 5, 397-402 DOI: http://dx.doi.org/10.3126/jpn.v3i5.7868