To evaluate the effect of material type on dimensional stability, occlusal surface wear, fracture resistance, and failure behavior of resin-based onlay restorations. A mandibular right first molar typodont was prepared and digitized using an intraoral scanner to virtually design an onlay restoration with the minimum occlusal thickness of 1.5mm. Resin-based onlay restorations (n = 15 per group) were fabricated either additively from 2 different resins indicated either for definitive or interim use or subtractively with a composite resin. After cementing onlays to corresponding dies, each of them was digitized before and after thermomechanical aging (B-STL and A-STL), and then subjected to load-to-failure test to evaluate fracture resistance. The B-STL and A-STL of each onlay were also compared to assess the dimensional stability and occlusal surface wear. One-way analysis of variance and Tukey honestly significant difference tests were used to evaluate dimensional stability, occlusal surface wear, and fracture resistance. The chi-square test was used to evaluate the Weibull modulus and characteristic strength among the groups (α = 0.05). Material type affected investigated outcomes (p<0.001). The additively manufactured resin indicated for definitive use led to the highest external surface deviations and the additively manufactured resin indicated for interim use led to the highest mesiodistal width deviations (p≤0.033). The onlays fabricated from the additively manufactured resin indicated for definitive use had the highest occlusal surface wear, while those in composite resin had the lowest (p≤0.006). The composite resin onlays had the highest fracture resistance values and reliability (p≤0.035). Tested subtractively manufactured composite resin had the lowest occlusal surface wear with the highest fracture resistance and reliability. Additively manufactured resins had lower dimensional stability, while tested resin for additively manufactured definitive restorations had the highest occlusal surface wear.
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