Event Abstract Back to Event The role of iron infusion in post-operative outcomes following radical cystectomy Ahmed Soualhi1*, Charlotte Moss2, Sachin Malde1, Rajesh Nair1, Ramesh Thurairaja1, Mieke Van Hemelrijck2 and Shamim Khan1 1 Guy's and St Thomas' NHS Foundation Trust, United Kingdom 2 King's College London, United Kingdom Background: It remains unknown whether pre-operative iron infusion to improve haemoglobin influences patient outcomes following radical cystectomy. This study reviewed a prospectively managed database to correlate iron infusion with post-operative outcomes. Methods: Patients with data on iron infusion before radical cystectomy between April 2015 and August 2018 were identified. Pre-operative and post-operative data collected included haemoglobin (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and iron. Surgical approach, blood loss, and blood transfusion information was also collected. Post-operative outcomes included inpatient complications, and complications at 30 and 90 days. Linear and logistic regression were used to evaluate the association between iron infusion and post-operative outcomes. Results: 209 patients were evaluated. 41 patients (20%) received an iron infusion. Compared to the 168 non-infused patients, iron-infused patients had significantly lower pre-operative Hb (p=0.001), PCV (p=0.005), MCV (p=0.035), MCH (p=0.012), and iron (p=0.009). No significant difference was found between the two groups in post-operative haematological values. Robot-assisted approach was used more for iron-infused than non-infused patients (95.1% vs. 74.3%, p=0.004). Blood loss in iron-infused patients was not significantly different to non-infused patients (p=0.985). No significant difference was found (p=0.899) in the need for blood transfusion between the two groups. There was no significant difference between the two groups for inpatient complications (p=0.342), 30-day (p=0.718), and 90-day complications (p=0.455). Conclusion: Patients needing, and given, an iron infusion showed similar post-operative haematological values compared to non-infused patients. However, pre-operative iron infusion is not associated with an improvement in post-operative outcomes following radical cystectomy. Keywords: Radical cystectomy, Iron, Post-cystectomy outcomes, haemoglobin, Anaemia Conference: Bladder Cancer Translational Research Meeting, London, United Kingdom, 29 Mar - 29 Mar, 2019. Presentation Type: Poster Topic: Development of personalised treatment Citation: Soualhi A, Moss C, Malde S, Nair R, Thurairaja R, Van Hemelrijck M and Khan S (2019). The role of iron infusion in post-operative outcomes following radical cystectomy. Front. Oncol. Conference Abstract: Bladder Cancer Translational Research Meeting. doi: 10.3389/conf.fonc.2019.01.00008 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Feb 2019; Published Online: 27 Sep 2019. * Correspondence: Mr. Ahmed Soualhi, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ahmed.soualhi@kcl.ac.uk Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Ahmed Soualhi Charlotte Moss Sachin Malde Rajesh Nair Ramesh Thurairaja Mieke Van Hemelrijck Shamim Khan Google Ahmed Soualhi Charlotte Moss Sachin Malde Rajesh Nair Ramesh Thurairaja Mieke Van Hemelrijck Shamim Khan Google Scholar Ahmed Soualhi Charlotte Moss Sachin Malde Rajesh Nair Ramesh Thurairaja Mieke Van Hemelrijck Shamim Khan PubMed Ahmed Soualhi Charlotte Moss Sachin Malde Rajesh Nair Ramesh Thurairaja Mieke Van Hemelrijck Shamim Khan Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.