Supra-second Intervals Research Articles

Neuroimaging Signatures of Metacognitive Improvement in Sensorimotor Timing.

Error monitoring is an essential human ability underlying learning and metacognition. In the time domain, humans possess a remarkable ability to learn and adapt to temporal intervals, yet the neural mechanisms underlying this are not clear. Recently, we demonstrated that humans improve sensorimotor time estimates when given the chance to incorporate previous trial feedback ( Bader and Wiener, 2021), suggesting that humans are metacognitively aware of their own timing errors. To test the neural basis of this metacognitive ability, human participants of both sexes underwent fMRI while they performed a visual temporal reproduction task with randomized supra-second intervals (1.5-6 s). Crucially, each trial was repeated following feedback, allowing a "re-do" to learn from the successes or errors in the initial trial. Behaviorally, we replicated our previous finding of improved re-do trial performance despite temporally uninformative (i.e., early or late) feedback. For neuroimaging, we observed a dissociation between estimating and reproducing time intervals. Estimation engaged the default mode network (DMN), including the superior frontal gyri, precuneus, and posterior cingulate, whereas reproduction activated regions associated traditionally with the "timing network" (TN), including the supplementary motor area (SMA), precentral gyrus, and right supramarginal gyrus. Notably, greater and more extensive DMN involvement was observed in re-do trials, whereas for the TN, it was more constrained. Task-based connectivity between these networks demonstrated higher inter-network correlation primarily when estimating initial trials, while re-do trial communication was higher during reproduction. Overall, these results suggest that the DMN and TN jointly mediate subjective self-awareness to improve timing performance.

Supra-second interval timing in bipolar disorder: examining the role of disorder sub-type, mood, and medication status

BackgroundWidely reported by bipolar disorder (BD) patients, cognitive symptoms, including deficits in executive function, memory, attention, and timing are under-studied. Work suggests that individuals with BD show impairments in interval timing tasks, including supra-second, sub-second, and implicit motor timing compared to the neuronormative population. However, how time perception differs within individuals with BD based on disorder sub-type (BDI vs II), depressed mood, or antipsychotic medication-use has not been thoroughly investigated. The present work administered a supra-second interval timing task concurrent with electroencephalography (EEG) to patients with BD and a neuronormative comparison group. As this task is known to elicit frontal theta oscillations, signal from the frontal (Fz) lead was analyzed at rest and during the task.ResultsResults suggest that individuals with BD show impairments in supra-second interval timing and reduced frontal theta power during the task compared to neuronormative controls. However, within BD sub-groups, neither time perception nor frontal theta differed in accordance with BD sub-type, depressed mood, or antipsychotic medication use.ConclusionsThis work suggests that BD sub-type, depressed mood status or antipsychotic medication use does not alter timing profile or frontal theta activity. Together with previous work, these findings point to timing impairments in BD patients across a wide range of modalities and durations indicating that an altered ability to assess the passage of time may be a fundamental cognitive abnormality in BD.

Investigation of the psychological length of a 1-s interval with a time production task.

Several studies using the production of 1-s intervals report instability in the results. This suggests that there is no clear representation of the value of 1 s in long-term memory. This instability may partly be explained by the specific methodological requirements of studies using 1-s production tasks. Typically, this task requires participants to produce 1-s intervals by either using two intermittent finger taps (one at the beginning and one at the end of the interval), or by continuously pressing a key for the duration of the second. The purpose of this study was to investigate the impact of two main factors on the production of 1-s intervals, namely the effects of kinesthetic cues (continuous press vs. two intermittent presses) and auditory cues (sound vs. no sound) during the production of each interval. Participants produced 30 1-s intervals under four conditions. The results showed significant effects of both kinesthetic and auditory factors on the produced intervals. The kinesthetic effects applied to both the accuracy (staying close to the 1-s target) and precision (minimizing intertrial variability), and the auditory effects were limited to accuracy. This study highlights that the expression of what is likely a representation of the psychological second in long-term memory is prone to much distortion. Explanations of this instability of the psychological second are explored, including the simultaneous involvement of circuits related to sub- (< 1 s) and supra-second (> 1 s) intervals and individual differences in the internal clock. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Why the clock ticks differently in Parkinson's disease: Insights from motor imagery and resting-state functional magnetic resonance imaging

In Parkinson's disease (PD), an impaired perception of suprasecond time intervals has been reported. From a neurobiological perspective, dopamine is thought to be an important mediator of timing. Nevertheless, it is still unclear whether timing deficits in PD occur mainly in the motor context and are associated with corresponding striatocortical loops. This study attempted to fill this gap by investigating time reproduction in the context of a motor imagery task, and its neurobiological correlates in resting-state networks of basal ganglia substructures in PD.Nineteen PD patients and 10 healthy controls therefore underwent two time reproduction tasks. In a motor imagery task, subjects were asked to walk down a corridor for 10 s and reproduce the time spent walking during motor imagery afterwards. In an auditory task, the subjects had to reproduce an acoustically presented time interval of 10 s. Subsequently, resting-state functional magnetic resonance imaging was performed and voxel-wise regressions were conducted between striatal functional connectivity and performance in the individual task at group level and compared between groups.Patients significantly misjudged the time interval in the motor imagery task and an auditory task in comparison to controls. Seed-to-voxel functional connectivity analysis of basal ganglia substructures revealed a significant association between striatocortical connectivity and motor imagery performance. PD patients showed a different pattern of associated striatocortical connections as indicated by significantly different regression slopes for connections of the right putamen and left caudate nucleus.In accordance with previous findings, our data confirm an impaired time reproduction of suprasecond time intervals in PD patients. Our data imply that deficits in time reproduction tasks are not specific to motor context but reflect a general time reproduction deficit. According to our findings, impaired performance in context of motor imagery is accompanied by a different configuration of striatocortical resting-state networks responsible for timing.

Age interferes with sensorimotor timing and error correction in the supra-second range.

Precise motor timing including the ability to adjust movements after changes in the environment is fundamental to many daily activities. Sensorimotor timing in the sub-and supra-second range might rely on at least partially distinct brain networks, with the latter including the basal ganglia (BG) and the prefrontal cortex (PFC). Since both structures are particularly vulnerable to age-related decline, the present study investigated whether age might distinctively affect sensorimotor timing and error correction in the supra-second range. A total of 50 healthy right-handed volunteers with 22 older (age range: 50-60 years) and 28 younger (age range: 20-36 years) participants synchronized the tap-onsets of their right index finger with an isochronous auditory pacing signal. Stimulus onset asynchronies were either 900 or 1,600 ms. Positive or negative step-changes that were perceivable or non-perceivable were occasionally interspersed to the fixed intervals to induce error correction. A simple reaction time task served as control condition. In line with our hypothesis, synchronization variability in trials with supra-second intervals was larger in the older group. While reaction times were not affected by age, the mean negative asynchrony was significantly smaller in the elderly in trials with positive step-changes, suggesting more pronounced tolerance of positive deviations at older age. The analysis of error correction by means of the phase correction response (PCR) suggests reduced error correction in the older group. This effect emerged in trials with supra-second intervals and large positive step-changes, only. Overall, these results support the hypothesis that sensorimotor synchronization in the sub-second range is maintained but synchronization accuracy and error correction in the supra-second range is reduced in the elderly as early as in the fifth decade of life suggesting that these measures are suitable for the early detection of age-related changes of the motor system.

A limited cerebellar contribution to suprasecond timing across differing task demands.

The involvement of the cerebellum in suprasecond interval timing (i.e., timing in the seconds to minutes range) is controversial. A limited amount of evidence from humans, nonhuman primates, and rodents has shown that the lateral cerebellum, including the lateral cerebellar nucleus (LCN), may be necessary for successful suprasecond timing performance. However, many existing studies have pitfalls, such as limited timing outcome measures and confounded task demands. In addition, many existing studies relied on well-trained subjects. This approach may be a drawback, as the cerebellum is hypothesized to carry out ongoing error correction to limit timing variability. By using only experienced subjects, past timing studies may have missed a critical window of cerebellar involvement. In the experiments described here, we pharmacologically inactivated the rat LCN across three different peak interval timing tasks. We structured our tasks to address past confounds, collect timing variability measures, and characterize performance during target duration acquisition. Across these various tasks, we did not find strong support for cerebellar involvement in suprasecond interval timing. Our findings support the existing distinction of the cerebellum as a subsecond interval timing brain region. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Pupillometry tracks errors in interval timing.

Recent primate studies suggest a potential link between pupil size and subjectively elapsed duration. Here, we sought to investigate the relationship between pupil size and perceived duration in human participants performing two temporal bisection tasks in the subsecond and suprasecond interval ranges. In the subsecond task, pupil diameter was greater during stimulus processing when shorter intervals were overestimated but also during and after stimulus offset when longer intervals were underestimated. By contrast, in the suprasecond task, larger pupil diameter was observed only in the late stimulus offset phase prior to response prompts when longer intervals were underestimated. This pattern of results suggests that pupil diameter relates to an error monitoring mechanism in interval timing. These results are at odds with a direct relationship between pupil size and the perception of duration but suggest that pupillometric variation might play a key role in signifying errors related to temporal judgments.

Dissociable Roles of Theta and Alpha in Sub-Second and Supra-Second Time Reproduction: An Investigation of their Links to Depression and Anxiety

Abstract A growing collection of observations has demonstrated the presence of multiple neural oscillations participating in human temporal cognition and psychiatric pathologies such as depression and anxiety. However, there remains a gap in the literature regarding the specific roles of these neural oscillations during interval timing, and how these oscillatory activities might vary with the different levels of mental health. The current study examined the participation of the frontal midline theta and occipital alpha oscillations, both of which are prevalent cortical oscillatory markers frequently reported in working memory and time perception paradigms. Participants performed a time reproduction task in the sub- (400, 600, 800 ms) and supra-second timescales (1600, 1800, 2000 ms) while undergoing scalp EEG recordings. Anxiety and depression levels were measured via self-report mental health inventories. Time–frequency analysis of scalp EEG revealed that both frontal midline and occipital alpha oscillations were engaged during the encoding of the durations. Furthermore, we observed that the correlational relationship between frontal midline theta power and the reproduction performance in the sub-second range was modulated by state anxiety. In contrast, the correlational relationship between occipital alpha and the reproduction performance of supra-second intervals was modulated by depression and trait anxiety. The results offer insights on how alpha and theta oscillations differentially play a role in interval timing and how mental health further differentially relates these neural oscillations to sub- and supra-second timescales.

Mental arithmetic modulates temporal variabilities of finger-tapping tasks in a tempo-dependent manner.

BackgroundSeveral psychiatric diseases impair temporal processing. Temporal processing is thought to be based on two domains: supra-second intervals and sub-second intervals. Studies show that temporal processing in sub-second intervals is mainly an automated process. However, the brain functions involved in temporal processing at each time scale remain unclear. We hypothesized that temporal processing in supra-second intervals requires several brain areas, such as the ventrolateral prefrontal cortex, intraparietal sulcus (IPS), and inferior parietal lobe, corresponding to various cognitions in a time scale-dependent manner. We focused on a dual-task paradigm (DTP) involving simultaneous performance of cognitive and motor tasks, which is an effective method for screening psychomotor functions; we then designed a DTP comprising finger tapping at various tempi as the temporal processing task and two cognitive tasks (mental arithmetic and reading) that might affect temporal processing. We hoped to determine whether task-dependent interferences on temporal processing in supra-second intervals differed depending on the cognitive tasks involved.MethodsThe study included 30 participants with no history of neuromuscular disorders. Participants were asked to perform a DTP involving right index finger tapping at varying tempi (0.33, 0.5, 1, 2, 3, and 4 s inter-tapping intervals). Cognitive tasks comprised mental arithmetic (MA) involving three-digit addition, mental reading (MR) of three- to four-digit numbers, and a control (CTL) task without any cognitive loading. For comparison between tasks, we calculated the SDs of the inter-tapping intervals. Participants’ MA abilities in the three-digit addition task were evaluated.ResultsThe MA and MR tasks significantly increased the SDs of the inter-tapping intervals compared to those of the CTL task in 2–3 s and 3–4 s for the MA and MR tasks, respectively. Furthermore, SD peaks in the finger-tapping tasks involving MA were normalized by those in the CTL task, which were moderately correlated with the participants’ MA ability (r = 0.462, P = 0.010).DiscussionOur results established that DTP involving the temporal coordination of finger-tapping and cognitive tasks increased temporal variability in a task- and tempo-dependent manner. Based on the behavioral aspects, we believe that these modulations of temporal variability might result from the interaction between finger function, arithmetic processing, and temporal processing, especially during the “pre-semantic period”. Our findings may help in understanding the temporal processing deficits in various disorders such as dementia, Parkinson’s disease, and autism.

Beyond the classic sensory systems: Characteristics of the sense of time of harbor seals (Phoca vitulina) assessed in a visual temporal discrimination and a bisection task.

Beyond the classic sensory systems, the sense of time is most likely involved from foraging to navigation. As a prerequisite for assessing the role time is playing in different behavioral contexts, we further characterized the sense of time of a harbor seal in this study. Supra-second time intervals were presented to the seal in a temporal discrimination and a temporal bisection task. During temporal discrimination, the seal needed to discriminate between a standard time interval (STI) and a longer comparison interval. In the bisection task, the seal learnt to discriminate two STIs. Subsequently, it indicated its subjective perception of test time intervals as resembling either the short or long STI more. The seal, although unexperienced regarding timing experiments, learnt both tasks fast. Depending on task, time interval or duration ratio, it achieved a high temporal sensitivity with Weber fractions ranging from 0.11 to 0.26. In the bisection task, the prerequisites for the Scalar Expectancy Theory including a constant Weber fraction, the bisection point lying close to the geometric mean of the STIs, and no significant influence of the STI pair condition on the probability of a long response were met for STIs with a ratio of 1:2, but not with a ratio of 1:4. In conclusion, the harbor seal's sense of time allows precise and complex judgments of time intervals. Cross-species comparisons suggest that principles commonly found to govern timing performance can also be discerned in harbor seals.

An Absence of a Relationship between Overt Attention and Emotional Distortions to Time: an Eye Movement Study

Abstract Emotional distortions to time are consistently reported in laboratory studies; however, their underlying causes remain unclear. One suggestion is that emotion-induced changes in attentional processes may contribute to emotional distortions to time. The current study tested this possibility by examining the relationship between eye movement and perceptions of the duration of emotional events. Participants completed a verbal estimation task in which they estimated the duration of positively, negatively and neutrally valenced images from the International Affective Picture System images. Time to first fixation and dwell time were recorded throughout. The results showed no significant relationships between measures of eye movement and measures of emotional distortion to time, despite the emotion manipulation successfully influencing the time before the participants first fixated on the to-be-timed stimulus. This suggests that for suprasecond intervals emotion-induced changes in overt attention processing do not contribute towards emotional distortions to time.

Impaired Motor Timing in Tourette Syndrome: Results From a Case-Control Study in Children.

Tourette syndrome (TS) is a neurodevelopmental disorder characterized by motor and vocal tics. Co-occurrence of attention-deficit/hyperactivity disorder (ADHD) or obsessive–compulsive disorder (OCD) is very frequent in the pediatric population as well as the presence of an impairment of the executive functions. The aim of our study was to investigate motor timing, that is, the temporal organization of motor behavior, in a pediatric population of Tourette patients. Thirty-seven Tourette patients (divided in 22 “pure” Tourette patients and 15 with ADHD) were compared with 22 healthy age- and gender-matched subjects. All subjects underwent a neuropsychiatric screening and were tested for their planning and decision-making abilities by using a standardized test, such as Tower of London (ToL). Two experimental paradigms were adopted: finger-tapping test (FTT), a free motor tapping task, and synchronization–continuation task. An accuracy index was calculated as measure of ability of synchronization. We found that “pure” TS as well as TS+ADHD showed lower scores in the FTT for the dominant and non-dominant hands than controls. Moreover, in the synchronization and continuation test, we observed an overall lack of accuracy in both TS groups in the continuation phase for 2,000 ms (supra-second interval), interestingly, with opposite direction of accuracy index. Thus, “pure” TS patients were classified as “behind the beat,” whereas, TS+ADHD as “ahead of the beat.” The performance in the finger tapping was inversely correlated to ToL total scores and execution time, whereas we did not find any correlation with the accuracy index of the synchronization and continuation test. In conclusion, here, we explored motor timing ability in a childhood cohort of Tourette patients, confirming that patients exhibit an impaired temporal control of motor behavior and these findings may be explained by the common underlying neurobiology of TS and motor timing.

Spontaneous and stimulus-driven rhythmic behaviors in ADHD adults and controls

Many aspects of human behavior are inherently rhythmic, requiring production of rhythmic motor actions as well as synchronizing to rhythms in the environment. It is well-established that individuals with ADHD exhibit deficits in temporal estimation and timing functions, which may impact their ability to accurately produce and interact with rhythmic stimuli. In the current study we seek to understand the specific aspects of rhythmic behavior that are implicated in ADHD. We specifically ask whether they are attributed to imprecision in the internal generation of rhythms or to reduced acuity in rhythm perception. We also test key predictions of the Preferred Period Hypothesis, which suggests that both perceptual and motor rhythmic behaviors are biased towards a specific personal ‘default’ tempo. To this end, we tested several aspects of rhythmic behavior and the correspondence between them, including spontaneous motor tempo (SMT), preferred auditory perceptual tempo (PPT) and synchronization-continuations tapping in a broad range of rhythms, from sub-second to supra-second intervals. Moreover, we evaluate the intra-subject consistency of rhythmic preferences, as a means for testing the reality and reliability of personal ‘default-rhythms’. We used a modified operational definition for assessing SMT and PPT, instructing participants to tap or calibrate the rhythms most comfortable for them to count along with, to avoid subjective interpretations of the task. Our results shed new light on the specific aspect of rhythmic deficits implicated in ADHD adults. We find that individuals with ADHD are primarily challenged in producing and maintaining isochronous self-generated motor rhythms, during both spontaneous and memory-paced tapping. However, they nonetheless exhibit good flexibility for synchronizing to a broad range of external rhythms, suggesting that auditory-motor entrainment for simple rhythms is preserved in ADHD, and that the presence of an external pacer allows overcoming their inherent difficulty in self-generating isochronous motor rhythms. In addition, both groups showed optimal memory-paced tapping for rhythms near their ‘counting-based’ SMT and PPT, which were slightly faster in the ADHD group. This is in line with the predictions of the Preferred Period Hypothesis, indicating that at least for this well-defined rhythmic behavior (i.e., counting), individuals tend to prefer similar time-scales in both motor production and perceptual evaluation.

Visual timing abilities of a harbour seal (Phoca vitulina) and a South African fur seal (Arctocephalus pusillus pusillus) for sub- and supra-second time intervals

Timing is an essential parameter influencing many behaviours. A previous study demonstrated a high sensitivity of a phocid, the harbour seal (Phoca vitulina), in discriminating time intervals. In the present study, we compared the harbour seal’s timing abilities with the timing abilities of an otariid, the South African fur seal (Arctocephalus pusillus pusillus). This comparison seemed essential as phocids and otariids differ in many respects and might, thus, also differ regarding their timing abilities. We determined time difference thresholds for sub- and suprasecond time intervals marked by a white circle on a black background displayed for a specific time interval on a monitor using a staircase method. Contrary to our expectation, the timing abilities of the fur seal and the harbour seal were comparable. Over a broad range of time intervals, 0.8–7 s in the fur seal and 0.8–30 s in the harbour seal, the difference thresholds followed Weber’s law. In this range, both animals could discriminate time intervals differing only by 12 % and 14 % on average. Timing might, thus be a fundamental cue for pinnipeds in general to be used in various contexts, thereby complementing information provided by classical sensory systems. Future studies will help to clarify if timing is indeed involved in foraging decisions or the estimation of travel speed or distance.

Direct and Indirect Timing Functions in Unilateral Hemispheric Lesions.

Introduction:The neural substrates of temporal processing are not still fully known. The majority of interval timing studies have dealt with this subject in the context of “Explicit timing” (computing the time intervals explicitly). The hypothesis “Implicit timing” (implicitly using temporal processing to improve function) has also proposed. This lesion study addressed explicit and implicit timing paradigms simultaneously using identical experimental tasks.Methods:In this case-control study, 15 patients with Right Hemisphere Damage (RHD) and 15 patients with Left Hemisphere Damage (LHD) and 15 age-matched normal subjects were included. Participants performed a temporal reproduction task (assessing explicit timing) and a temporal prediction task (assessing implicit timing) in two sub- and supra-second intervals.Results:Our results showed that RHD can lead to significantly lower accuracy in the temporal reproduction task in sub-second (P=0.005) and supra-second (P=0.001) intervals, compared with the normal subjects. Also, LHD led to perturbation in temporal prediction task by an increase in reaction time (lower accuracy) in sub- (P=0.011) and supra-second (P=0.006) time intervals than the normal subjects.Conclusion:Overall, our findings suggested that there is a right hemispheric bias in the neural substrate of explicit timing, in both sub- and supra-second intervals. Furthermore, for the first time in a lesion study, we showed the evidence of left-hemispheric bias in neural substrates of implicit timing.

Humans derive task expectancies from sub-second and supra-second interval durations.

Recent studies in the field of task switching have shown that humans can base expectancies for tasks on temporal cues. When tasks are predictable based on the duration of the preceding pre-target interval, humans implicitly adapt to this predictability, indicated by better performance in trials with validly compared to invalidly predicted tasks. Yet, it is not clear which internal timing mechanisms are involved. Previous research has suggested that intervals from the sub- and supra-second range are processed by distinct cognitive timing systems. As earlier studies on temporally predictable task switching have used predictive intervals stemming from both ranges, it was not yet clear if the time-based expectancy effect was driven by just one of the two internal timing systems. The present study used clearly sub-second intervals (10ms and 500ms) in Experiment 1, while clearly supra-second intervals (1500ms and 3000ms) were used in Experiment 2. Substantial adaptation effects were observed in both experiments, showing that sub- as well as supra-second timing systems are involved in time-based expectancies for tasks. The present findings offer important implications for our theoretical understanding of the internal timing mechanisms involved in time-based task expectancy.

Role of the supplementary motor area during reproduction of supra-second time intervals: An intracerebral EEG study

The supplementary motor area (SMA) has been shown to be involved in interval timing but its precise role remains a matter of debate. The present study was aimed at examining, by means of intracerebral EEG recordings, the time course of the activity in this structure, as well as in other functionally connected cortical (frontal, cingulate, insular and temporal) areas, during a visual time reproduction task. Four patients undergoing stereo-electroencephalography (SEEG) for presurgical investigation of refractory focal epilepsy were enrolled. They were selected on the presence of depth electrodes implanted within the SMA. They were instructed to encode, keep in memory and then reproduce the duration (3, 5 and 7 s) of emotionally-neutral or negative pictures. Emotional stimuli were used with the aim of examining neural correlates of temporal distortions induced by emotion. Event-related potentials (ERPs) were analyzed during three periods: During and at the extinction of the target interval (TI) and at the beginning of the reproduction interval (RI). Electrophysiological data revealed an ERP time-locked to TI-offset whose amplitude varied monotonically with TI-duration. This effect was observed in three out of the four patients, especially within the SMA and the insula. It also involved the middle and anterior cingulate cortex, the superior, middle and inferior frontal gyri and the paracentral lobule. These effects were modulated by the prior TI-duration and predicted variations in temporal reproduction accuracy. In contrast, modulations of ERPs with TI-duration, emotion or temporal performance during the target or the reproduction interval were modest and less consistent across patients. These results demonstrate that, during reproduction of supra-second time intervals, the SMA, in concert with a fronto-insular network, is involved at the end of the target interval, and suggest a role in the duration categorization and decision making operations or alternatively in the preparedness of the timing of the future movement that will be executed during the reproduction phase.

The effects of microdose LSD on time perception: a randomised, double-blind, placebo-controlled trial

RationalePrevious research demonstrating that lysergic acid diethylamide (LSD) produces alterations in time perception has implications for its impact on conscious states and a range of psychological functions that necessitate precise interval timing. However, interpretation of this research is hindered by methodological limitations and an inability to dissociate direct neurochemical effects on interval timing from indirect effects attributable to altered states of consciousness.MethodsWe conducted a randomised, double-blind, placebo-controlled study contrasting oral administration of placebo with three microdoses of LSD (5, 10, and 20 μg) in older adults. Subjective drug effects were regularly recorded and interval timing was assessed using a temporal reproduction task spanning subsecond and suprasecond intervals.ResultsLSD conditions were not associated with any robust changes in self-report indices of perception, mentation, or concentration. LSD reliably produced over-reproduction of temporal intervals of 2000 ms and longer with these effects most pronounced in the 10 μg dose condition. Hierarchical regression analyses indicated that LSD-mediated over-reproduction was independent of marginal differences in self-reported drug effects across conditions.ConclusionsThese results suggest that microdose LSD produces temporal dilation of suprasecond intervals in the absence of subjective alterations of consciousness.

Individual differences in first- and second-order temporal judgment.

The ability of subjects to identify and reproduce brief temporal intervals is influenced by many factors whether they be stimulus-based, task-based or subject-based. The current study examines the role individual differences play in subsecond and suprasecond timing judgments, using the schizoptypy personality scale as a test-case approach for quantifying a broad range of individual differences. In two experiments, 129 (Experiment 1) and 141 (Experiment 2) subjects completed the O-LIFE personality questionnaire prior to performing a modified temporal-bisection task. In the bisection task, subjects responded to two identical instantiations of a luminance grating presented in a 4deg window, 4deg above fixation for 1.5 s (Experiment 1) or 3 s (Experiment 2). Subjects initiated presentation with a button-press, and released the button when they considered the stimulus to be half-way through (750/1500 ms). Subjects were then asked to indicate their ‘most accurate estimate’ of the two intervals. In this way we measure both performance on the task (a first-order measure) and the subjects’ knowledge of their performance (a second-order measure). In Experiment 1 the effect of grating-drift and feedback on performance was also examined. Experiment 2 focused on the static/no-feedback condition. For the group data, Experiment 1 showed a significant effect of presentation order in the baseline condition (no feedback), which disappeared when feedback was provided. Moving the stimulus had no effect on perceived duration. Experiment 2 showed no effect of stimulus presentation order. This elimination of the subsecond order-effect was at the expense of accuracy, as the mid-point of the suprasecond interval was generally underestimated. Response precision increased as a proportion of total duration, reducing the variance below that predicted by Weber’s law. This result is consistent with a breakdown of the scalar properties of time perception in the early suprasecond range. All subjects showed good insight into their own performance, though that insight did not necessarily correlate with the veridical bisection point. In terms of personality, we found evidence of significant differences in performance along the Unusual Experiences subscale, of most theoretical interest here, in the subsecond condition only. There was also significant correlation with Impulsive Nonconformity and Cognitive Disorganisation in the sub- and suprasecond conditions, respectively. Overall, these data support a partial dissociation of timing mechanisms at very short and slightly longer intervals. Further, these results suggest that perception is not the only critical mitigator of confidence in temporal experience, since individuals can effectively compensate for differences in perception at the level of metacognition in early suprasecond time. Though there are individual differences in performance, these are perhaps less than expected from previous reports and indicate an effective timing mechanism dealing with brief durations independent of the influence of significant personality trait differences.

Caloric primary rewards systematically alter time perception.

Human time perception can be influenced by contextual factors, such as the presence of reward. Yet, the exact nature of the relationship between time perception and reward has not been conclusively characterized. We implemented a novel experimental paradigm to measure estimations of time across a range of suprasecond intervals, during the anticipation and after the consumption of fruit juice, a physiologically relevant primary reward. We show that average time estimations were systematically affected by the consumption of reward, but not by the anticipation of reward. Compared with baseline estimations of time, reward consumption was associated with subsequent overproductions of time, and this effect increased for larger magnitudes of reward. Additional experiments demonstrated that the effect of consumption did not extend to a secondary reward (money), a tasteless, noncaloric primary reward (water), or a sweet, noncaloric reward (aspartame). However, a tasteless caloric reward (maltodexrin) did induce overproductions of time, although this effect did not scale with reward magnitude. These results suggest that the consumption of caloric primary rewards can alter time perception, which may be a psychophysiological mechanism by which organisms regulate homeostatic balance. (PsycINFO Database Record