Pubis osteomyelitis is a rare bone infection disease. The clinical manifestations of this disease are highly misleading. The symptoms are non-specific and the patients feel pain in their pelvis and have difficulties in walking. The risk factors for this disease are pelvic and urological surgeries. Case Presentation: In this report, a 40-year-old female with suprapubic fistula secretion 6 months after reconstructive surgery for bladder prolapse was introduced. In fistulectomy surgery, pelvic pubis osteomyelitis was identified and treated by curettage and debridement. Inmicroorganism cultureof the samples, Staphylococcus epidermidiswas the result,whichwas resistant tomethicillin. Conclusions: Antibiotic treatment is not enough for pubic osteomyelitis. Curettage and jet lavage surgeries are suggested. Closing the possible route by the urogenital tract is of great importance in controlling the disease.