Suppression Ability Research Articles

LCL APF control strategy based on model predictive control

In order to further control harmonic current in distribution network, a LCL APF control strategy based on model predictive control is proposed. Firstly, APF mathematical model is established. Then, a multi-objective optimization model predictive control strategy (MPC) is proposed, which comprehensively considers the performance of AC side and DC side of APF. This strategy solves the delay problem existing in the existing MPC strategy: while improving the performance of APF, there is no need to set weight factor; Then, Kalman filter is used to predict the inverter current, thus simplifying the APF measurement system. Finally, the simulation results show that the proposed control strategy can simplify the measurement system and make APF have stronger harmonic suppression ability when it only participates in power conversion and better active filter performance when it participates in harmonic control.

Design of a miniaturized 90-degree quadrature hybrid coupler with harmonic suppression ability using π-shaped lumped elements

This research presents a new design and fabrication of a quadrature hybrid coupler using π-shaped lumped elements. The proposed π-shaped elements have resulted in ultra-size reduction and harmonic suppression ability simultaneously. The proposed coupler correctly works at 800 MHz, the insertion loss is less than 0.15 dB and more than 26 dB, isolation and return loss are obtained at the operating frequency. The size of the proposed coupler is only 12.8 mm ×12.2 mm, which is equal to 0.046 λg × 0.044 λg, where λg is of the guided-wavelength at 800 MHz. The conventional coupler has a large size of 0.25 λg × 0.25 λg, which is equal to 68.5 mm × 68.5 mm. The proposed coupler provides about 96% size reduction compared to the conventional coupler. Moreover, the proposed quadrature hybrid coupler has wide harmonic suppression from 2.1 GHz to 10 GHz.

Dual-Functional SnO2-CNT-PANI||PP||SnO2 Separator for Enhanced Lithium-Sulfur Battery Stability and Capacity

Lithium-sulfur batteries (LSBs) provide high capacity and energy density for advanced energy storage but encounter performance and safety issues due to lithium polysulfides (LiPSs) dissolution and dendrite formation. This study introduces a dual-functional SnO2-CNT-PANI||PP||SnO2 separator (DF-SNCPS) aimed at improving the stability and safety of LSBs. The separator includes a SnO2-CNT-PANI layer on the sulfur cathode side for enhanced electrical conductivity and polysulfide adsorption and a SnO2 nanoparticle (nano-SnO2) layer on the lithium anode side to regulate lithium-ion concentration and inhibit dendrite growth. Density functional theory (DFT) and the phase field method have verified the relevant material's catalytic performance and dendrite suppression ability. These methods have provided a comprehensive understanding of the underlying mechanisms, providing auxiliary explanations for their role in catalyzing polysulfide conversion and suppressing lithium dendrite growth. This innovative design mitigates the shuttle effect and enhances cyclic stability and sulfur utilization, achieving a notable cyclic performance with a capacity retention of 0.05% per cycle over 800 cycles at 1C. The synergistic effects of the modified separator present a viable pathway for LSB commercialization.

Long‐Life All‐Solid‐State Batteries Enabled by Cold‐Pressed Garnet Composite Electrolytes with Enhanced Li+ Conduction

AbstractGarnet Li7La3Zr2O12 (LLZO)‐based solid‐state electrolytes (SSEs) hold promise for realizing next‐generation lithium metal batteries with high energy density. However, the high stiffness of high‐temperature sintered LLZO makes it brittle and susceptible to strain during the fabrication of solid‐state batteries. Cold‐pressed LLZO exhibits improved ductility but suffers from insufficient Li+ conductivity. Here, we report cold‐pressed Ta‐doped LLZO (Ta−LZ) particles integrated with ductile Li6PS5Cl (LPSC) via a Li+ conductive Li‐containing Ta−Cl structure. This configuration creates a continuous Li+ conduction network by enhancing the Li+ exchange at the Ta−LZ/LPSC interface. The resulting Ta−LZ/LPSC SSE exhibits Li+ conductivity of 4.42×10−4 S cm−1 and a low activation energy of 0.31 eV. Li symmetric cells with Ta−LZ/LPSC SSE demonstrate excellent Li dendrite suppression ability, with an improved critical current density of 5.0 mA cm−2 and a prolonged cycle life exceeding 600 h at 1 mA cm−2. Our finding provides valuable insights into developing cold‐pressed ceramic powder electrolytes for high‐performance all‐solid‐state batteries.

Construction of epoxy resin with enhanced flame retardancy, mechanical properties, and satisfactory transparency based on a novel bi‐DOPO and hydrogen‐bonding network

AbstractEstablishment of high‐performance epoxy resin with satisfactory fire safety, mechanical properties, and excellent transparency is urgently desirable, but still remains significant challenges. Herein, a super‐tough yet high flame retardant epoxy resin (EP/BTD) was designed and prepared by incorporating bi‐DOPO structure and hydrogen‐bonding networks. Although the phosphorus content was only 0.69 wt% (10 wt% of bi‐DOPO flame retardant [BTD]), EP/BTD‐10 showed a high limiting oxygen index value (33.4%), satisfactory UL‐94 rating (V‐0), and good heat suppression ability (total heat release [THR] and peak heat release rate [PHRR] reduced to 29.0% and 42.2%, respectively). Furthermore, the flame retardant mechanism of EP/BTD was illustrated and attributed to dual‐phase fire‐retardant effect. Additionally, EP/BTD‐7.5 featured notably mechanical properties, of which the tensile strength, elongation at break and impact strength increased by 44.6%, 40.0%, and 232.6%, respectively, due to hydrogen‐bonding network and π–π interaction. More importantly, EP/BTD maintained high visible light transmittance and excellent UV‐blocking properties. In summary, this work provided a guidance for the development of high‐performance epoxy resin and was expected to expand the practical applications.

Mapping predicted biomass in cereal rye using 3D imaging and geostatistics

Abstract Cover crops are becoming an increasingly important tool for weed suppression. Biomass production in cover crops is one of the most important predictors of weed suppressive ability. A significant challenge for growers is that cover crop growth can be patchy within fields, making biomass estimation difficult. This study tested ground-based structure-from-motion (SfM) for estimating and mapping cereal rye (Secale cereale L.) biomass. SfM generated 3D point clouds from red, green, and blue (RGB) videos collected by a handheld GoPro camera over five fields in North Carolina during the 2022 to 2023 winter season. A model for predicting biomass was generated by relating measured biomass at termination using a density–height index (DH) from point cloud pixel density multiplied by crop height. Overall biomass ranged from 320 to 9,200 kg ha−1, and crop height ranged from 10 to 120 cm. Measured biomass at termination was linearly related to DH (r2 = 0.813) through levels of 9,000 kg ha−1. Based on independent data validation, predicted biomass and measured biomass were linearly related (r2 = 0.713). In the field maps generated by kriging, measured biomass data were autocorrelated at a range of 5.4 to 42.2 m, and predicted biomass data were autocorrelated at a range of 3.4 to 12.0 m. However, the spatial arrangement of high- and low-performing areas was similar for predicted and measured biomass, particularly in fields with greatest patchiness and spatial correlation in biomass values. This study provides proof-of-concept that ground-based SfM can potentially be used to nondestructively estimate and map cover crop biomass production and identify low-performing areas at higher risk for weed pressure and escapes.

Does a native and introduced cover crop species differ in their ability to suppress weeds? A study in a table grape vineyard

This study compared the weed suppression ability of a native cover crop species phacelia (Phacelia tanacetifolia), an introduced cover crop species rye (Secale cereale L.), and a no cover crop (herbicide‑managed) system in a vineyard. Cover crops were sown in the interrow spaces of the grapevine rows. Percent weed cover after the cover crop termination was lower in the interrow of the phacelia than the no cover crop plots. During the cover crop growing season, phacelia suppressed weeds more than rye. However, the weed seedbank of the cover crop plots was greater than that of the no cover crop plots.

Frequency-independent dual-tuned cable traps for multi-nuclear MRI and MRS

Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) of non-proton nuclei (X-nuclei) typically require additional proton imaging for anatomical reference and B0 shimming. Therefore, two RF systems exist, necessitating cable traps to block the unwanted common-mode current at both Larmor frequencies of 1H and X-nuclei. This study introduces a frequency-independent dual-tuned cable trap that combines a standard solenoid cable trap with a float solenoid trap to independently tune high and low frequencies without compromising performance. The methods involved theoretical analysis, electromagnetic simulations, and bench tests. Two design approaches were evaluated: a float cable trap for 1H, a non-float cable trap for X-nuclei, and vice versa. Results showed that the design with the float trap for X-nuclei and non-float for 1H had superior performance, with high common-mode current suppression ability at both frequencies. Bench tests confirmed these findings, demonstrating effectiveness across various static fields and X-nuclei. The proposed frequency-independent dual-tuned cable trap provides a compact and efficient solution for multinuclear MRI and MRS, enhancing safety, image quality, and flexibility.

Paclitaxel prodrug nanoparticles boost antitumor efficacy via hitchhiking of human serum albumin

Improving drug delivery efficacy is the key point for enhancing the therapeutic index of medicines. Herein, we report fatty chain conjugated paclitaxel (PTX) prodrugs with a disulfide bond as linker. The formed prodrugs can self-assemble into stable nanoparticles in aqueous solutions, and rapidly transform into long-circulating nanocomplexes via the non-covalent binding to serum albumin in blood, enabling efficient drug delivery and robust antitumor effect. PTX prodrug (PC) with single-chain possess the improved self-assembly and interaction with albumins. The formed PC@albumin nanocomplexes reinforce the responsiveness of prodrug activation, and exhibit the enhanced tumor suppression ability. This strategy of hitchhiking albumin to deliver therapeutic agents holds great promise for enhanced chemotherapy.

Extraction and structural analysis of mannoproteins from different species of yeast: Bitter suppression and the potential mechanisms for wine

To rich the research for mannoproteins (MPs) suppressive effect on the bitterness of wine, this study distinguished bitterness into initial bitterness and bitter aftertaste. By utilizing the thermal alkali extraction method, MPs were extracted from three different yeast species: Saccharomyces cerevisiae (CECA), Lachancea thermotolerans (A38), and Torulaspora delbrueckii (2082). Their basic structures, addition concentrations, and correlation with bitter suppression ability were characterized. CECA exhibited stronger initial bitterness suppression ability, may attributed to its more branches and lack of a triple-helix structure. 2082 showed greater bitter aftertaste suppression and might due to smaller particle aggregation, fewer branches, and triple-helix structure. Additionally, it was noteworthy that due to the unique structure of 2082, it may bound more monomer and oligomeric proanthocyanidins (MOPC) on MPs surface, reducing its initial bitterness suppression ability. Concerning concentration, the increase in polysaccharide chain polymerization hindered further interaction with MOPC, leading to a decrease in its initial bitterness suppression ability. Bitter aftertaste exhibited different behaviors. As the concentration of CECA increased, there was an increase in oral adhesion instead.

SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.

LACTB is identified as a tumor suppressor in several tumors. However, preliminary study reveals that LACTB is overexpressed in osteosarcoma and indicates poor prognosis. Two missense mutations (rs34317102 and rs2729835) exist simultaneously in 92.31% of osteosarcoma patients and cause M5L and R469K double mutations in LACTB, suggesting the biologic function of LACTB protein may be altered in osteosarcoma. Moreover, LACTBM5L+R469K overexpression can promote malignant progression in different tumors, which suggests that the M5L and R469K mutations confer oncogene-like functions to LACTB. Mechanistically, LACTBM5L+R469K not only reduces the wild type p53 via enhancing PSMB7 catalytic activity, but also protects p53R156P protein from lysosomal degradation, which suggesting LACTBM5L+R469K is a dual-regulator for wt-p53 and mutant p53, and derive oncogene-like functions. More importantly, clavulanate potassium, a bacterial β-lactamase inhibitor, can inhibit osteosarcoma proliferation and sensitize osteosarcoma to cisplatin by binding and blocking LACTBM5L+R469K. These findings revealed that the M5L and R469K double mutations can diminish the tumor suppressive ability of wild type LACTB and provide oncogene-like functions to LACTB. Inhibiting LACTBM5L+R469K can suppress the progression of osteosarcoma harbouring wild-type or mutant p53. Clavulanate potassiumis a promising drug by targeting LACTBM5L+R469K-p53 pathway for the treatment of osteosarcoma patients.

Extracorporeal Photopheresis Enhances the Frequency and Function of Highly Suppressive FoxP3+ Treg Subsets in Heart Transplanted Individuals.

Extracorporeal photopheresis (ECP) has emerged as a prophylactic and therapeutic immunomodulatory option for managing acute rejection in heart transplants (HTx). The underlying mechanisms through which ECP exerts its immunomodulatory effects remain under investigation. Regulatory T cells (Treg) are a heterogeneous subset of immune lymphocytes that ensure the maintenance of tissue homeostasis, avoiding graft rejection. The transcription factor forkhead box protein 3 (FoxP3) is an essential molecular marker of Treg, acting as a "master regulator" of their genesis, stability, and functions. No study has investigated whether ECP impacts FoxP3 expression and its highly suppressive variants containing the exon 2 (FoxP3-E2), particularly in HTx. In the current study, we recruited 14 HTx participants who had undergone ECP therapy. We explored the effect of in vivo ECP on CD4+FoxP3+ Treg frequency and in vitro suppressive function in 8 HTx participants before (T0) and after 3 (T1), 6 (T2), and 12 (T3) mo of treatment. As a control group, we included 4 HTx individuals who had not undergone ECP therapy. We found that ECP increases the frequency of CD4+FoxP3+ Treg subset with highly suppressive phenotype, including CD4+FoxP3-E2+ Treg. At functional levels, we observed that ECP treatment in HTx individuals effectively improves Treg suppressive ability in controlling the proliferation of autologous conventional CD4+ T lymphocytes. Our findings collectively suggest that ECP exerts its immunomodulatory effects in HTx individuals by positively impacting the frequency and regulatory function of the FoxP3+ Treg compartment.

Improved MSTOGI-PLL with enhanced control under non-ideal grid voltage conditions

Integration structure of second- and third-order generalized integrator phase-locking loop (MSTOGI-PLL) has received attention for the processing ability of harmonics and DC bias contained in grid voltage. However, due to that MSTOGI-PLL is sensitive to interharmonics and subharmonics, once low order harmonics dominate, the narrow bandwidth will result in slow response. Hence, based on the analysis on input and output frequency characteristics of existing MSTOGI, a frequency gain structure within the MSTOGI structure is added to improve the suppression ability, either to low-frequency or high-frequency harmonics. Secondly, in order to accelerate response and reduce overshoot of the output frequency of the phase-locked loop (PLL), a nonlinear PI dynamic regulator based on a hyperbolic threshold function is constructed. Furthermore, from the perspectives of voltage phase and frequency tracking error indicators, by comparing with three other types of PLL structures in weak grid application, the effectiveness of the proposed method is verified through simulation cases. Finally, a physical hardware platform based on dSPACE1104 is built to extract the grid voltage from the three-phase voltage regulating transformer, the theoretical derivation and simulation results are verified. The phase deviation is controlled within 0.44 rad s-1, and frequency deviation is controlled within 0.07 Hz.

An In Situ Generated Organic/Inorganic Hybrid SEI Layer Enables Li Metal Anodes with Dendrite Suppression Ability, High-Rate Capability, and Long-Life Stability.

High-quality solid electrolyte interphase (SEI) layers can effectively suppress the growth of Li dendrites and improve the cycling stability of lithium metal batteries. Herein, 1-(6-bromohexanoyl)-3-butylurea is used to construct an organic/inorganic hybrid (designated as LiBr-HBU) SEI layer that features a uniform and compact structure. The LiBr-HBU SEI layer exhibits superior electrolyte wettability and air stability as well as strong attachment to Li foils. The LiBr-HBU SEI layer achieves a Li+ conductivity of 2.75 × 10-4 S cm-1, which is ≈50-fold higher than the value measured for a native SEI layer. A Li//Li symmetric cell containing the LiBr-HBU SEI layer exhibits markedly improved cyclability when compared with the cell containing a native SEI layer, especially at a high current density (e.g., cycling life up to 1333h at 15mA cm-2). The LiBr-HBU SEI layer also improves the performance of lithium-sulfur cells, particularly the rate capability (548 mAh g-1 at 10C) and cycling stability (513 mAh g-1 at 0.5C after 500 cycles). The methodology described can be extended to the commercial processing of Li metal anodes as the artificial SEI layer also protects Li metal against corrosion.

Performance enhancement of lead‑carbon batteries by bi-based metal-organic framework-derived carbon materials

Lead‑carbon batteries (LCBs) cannot replace lead-acid batteries for large-scale applications in daily life due to the acceleration of hydrogen evolution reaction by carbon materials during the cycling process. In this study, we selected a Bi-based metal-organic framework as a carbon precursor, and prepared carbon composites containing Bi and its oxides (Bi@C) via a simple calcination method. The composites were characterized and tested for battery performance. The results show that the inherent rod-like structure of Bi@C material still exists at 600 °C and it effectively improves the conductivity of the negative active material (NAM). Under HRPSoC conditions, the battery with 2 % Bi@C reaches a cycle life of 7331 cycles, 3.9 times that of a blank battery. The improved performance of LCBs is attributed to the high conductivity, hydrogen evolution suppression ability and uniqe rod-like structure of Bi@C material, which effectively increase the conversion rate of active materials, thus extending the battery lifespan. This research provides a more economical and simpler approach for optimizing the combination of carbon with other metal elements to address the problem of hydrogen evolution in lead‑carbon batteries.

Flexible Regulation of Positive and Negative Emotion Expression: Reexamining the Factor Structure of the Flexible Regulation of Emotional Expression Scale (FREE) Based on Emotion Valence.

The Flexible Regulation of Emotional Expression (FREE) Scale assesses individuals' ability to enhance and suppress their emotional expressions across different situations. This study investigates the optimal factor structure of the FREE and emphasizes the importance of distinguishing between the regulation abilities for positive and negative expressions. A sample of 607 undergraduates (Mage = 19.02, SD = 1.02, 72.2% female) from Mainland China completed the questionnaire survey. Confirmatory factor analyses tested eight competing models of the FREE structure. Results indicated that the second-order model, featuring two higher-order factors (expressive enhancement and suppression abilities), fit the data well. An alternative second-order model, with two different higher-order factors (positive and negative emotion expressive abilities) and the same four first-order factors, demonstrated an even better fit. Various types of expressive ability scores showed predictive validity regarding emotion regulation self-efficacy, mental health outcomes, and relationship stress. Regulation of emotional expression can be represented by either regulation type or emotion valence, with the latter providing more informative insights. Flexible regulation of positive and negative emotion expression predicted fewer symptoms of depression, anxiety, stress, and relationship stress beyond emotion regulation self-efficacy. These findings highlight the importance of considering emotional valence in understanding flexibility in expression regulation.

Biological control of downy mildew Peronosclerospora spp. L. by application of endophytic agents in corn

ABSTRACT This research was carried out to evaluate endophytic biocontrol agents (eBCA) in inducing corn plant resistance to downy mildew Peronosclerospora spp. In this context, the estimation of total phenolic content and peroxidase (POD) enzyme activity was carried out in contrast to control without induction treatments. Corn seed treatment using three eBCA II.D2.2, DC.5, and AC.3 on susceptible and tolerant cultivars in a screenhouse and field showed variation in downy mildew reduction. The results showed that Trichoderma asperellum AC.3 treatment suppressed downy mildew by 2.7–23.0% in the screen house. In the field, resistance induction by applications of Bacillus cereus II.D2.2, Fusarium verticillioides DC.5, and T. asperellum AC.3 suppressed the infection from 23% to 79% on susceptible cultivars. However, the T. asperellum AC.3 treatment reported the highest suppression of 55–79% on tolerant and susceptible cultivars. Resistant induction with F. verticillioides DC.5 increased POD enzyme activity by 300.5% and suppressed the infection by 63% in the field. The pathogen suppression ability through the induction with eBCA was related to triggering the increase of total phenolic content and POD enzyme activity in plant tissues. Applications of B. cereus II.D2.2, F. verticillioides DC.5, and T. asperellum AC.3 suppressed downy mildew infection in the field through the induction of total phenolic content and POD enzyme activity in corn. Meanwhile, the best treatment using T. asperellum AC.3 was lower by 30–70% than the application of synthetic fungicide as control.

Mutant P53 modulation by cryptolepine through cell cycle arrest and apoptosis in triple negative breast cancer

BackgroundTriple Negative Breast cancer is an aggressive breast cancer subtype. It has a more aggressive clinical course, an earlier age of onset, a larger propensity for metastasis, and worse clinical outcomes as evidenced by a higher risk of recurrence and a shorter survival rate. Currently, the primary options for TNBC treatment are surgery, radiation, and chemotherapy. These treatments however remain ineffective due to recurrence. However, given that p53 mutations have been identified in more than 60–88 % of TNBC, translating p53 into the clinical situation is particularly important in TNBC. In this study, we screened and evaluated the therapeutic potential of cryptolepine (CRP) in TNBC in-vitro models being an anti-malarial drug it could be repurposed as an anti-cancer therapeutic targeting TNBC. Moreover, the cytotoxicity activity of cryptolepine to TNBC cells and a detailed anti-tumor mechanism in mutant P53 has not been reported before. MethodsMTT assays were used to examine the cytotoxicity and cell viability activity of Cryptolepine in TNBC, non-TNBC T47D and MCF-7 and non-malignant MCF10A cells. Scratch wound and clonogenic assay was used to evaluate the cryptolepine’s effect on migration and colony forming ability of TNBC cells. Flow cytometry, MMP and DAPI was used to assess cell cycle arrest and cell apoptosis mechanism. The expression of proteins was detected by western blots. The differential expression of RNAs was evaluated by RT-PCR and the interaction between P53 and drug was evaluated computationally using in-silico approach and in-vitro using ChIP assay. ResultsIn this study, we found that cryptolepine has more preferential cytotoxicity in TNBC than non-TNBC cells. Notably, our studies revealed the mechanism by which cryptolepine induces intrinsic apoptosis and inhibit migration, colony formation ability, induce cell cycle arrest by inducing conformational change in the mutant P53 thereby increasing its DNA binding ability, hence activating its tumor suppressing potential significantly. ConclusionOur study revealed that CRP significantly reduced the proliferation, migration and colony forming ability of TNBC cells lines. Moreover, it was revealed that CRP induces cell cycle arrest and apoptosis by activating mutant P53 and enhancing its DNA binding ability to induce its tumor suppressing ability.

A Modified ADRC Scheme Based on Model Information for Maglev Train

During the operation of maglev trains, they are subjected to various disturbances. The presence of these disturbances presents a significant challenge for attaining high-performance control and even poses the risk of system instability. To further enhance the anti-disturbance capability of maglev trains, this paper proposes a model information-assisted modified active disturbance rejection control (MADRC) approach. A mathematical model of the single-point suspension system of maglev trains is constructed for the design of the extended state observer (ESO), which is a modified extended state observer (MESO), and a nonlinear mechanism is incorporated to boost the performance of the ESO. Owing to the introduction of model information, the estimated quantity of disturbances by MESO no longer considers the system model deviation as a disturbance. Hence, the linear feedback control law is modified accordingly. The MESO is regarded as an ESO with time-varying gain using the equivalent gain method, and its stability is proven using the Lyapunov method. The tracking and anti-disturbance performances of different controllers are compared via simulation experiments. Suspension and anti-disturbance experiments are conducted on the single-point suspension experimental platform, verifying that the proposed MADRC has a more potent suppression ability for load disturbances in the suspension system.

Draft genome sequence of the fungal biocontrol agent, Bacillus velezensis Kos.

Here, we report the draft genome sequence of Bacillus velezensis strain Kos, isolated from casing soil used during Agaricus bisporus cultivation in Dublin, Ireland. B. velezensis Kos exhibits a suppressive ability toward Cladobotryum mycophilum, Trichoderma aggressivum, and Lecanicillium fungicola, which are common threats to A. bisporus production, cultivation, and quality.