Background: Psychological and information-based interventions can positively impact health-related quality of life (QOL) in patients with chronic disease. Aim: To test a web-enabled home program (IBDC) of self-management, information, and peer support for pediatric IBD patients and their parents. Methods: In a series of n-of-1 studies, 40 patients (and 40 parents) were assessed during standard care and subsequently, IBDC care. Patients were enrolled with active disease, followed for two months to achieve remission, then entered six month control period with standard care, and finished with six month of IBDC intervention. The primary outcome was QOL, measured by IMPACT-III, with secondary outcomes of disease-specific knowledge (the IBD-KID), adherence to therapy, perceived stress and health care utilization. Results: Of 40 enrolled patient/parent dyads, data was available for analysis from the first seven dyads. For the 7 patient participants, mean age was 14.6 ± 2 yrs, 5 Crohn's disease (CD), 2 ulcerative colitis (UC). At study entry, mean PCDAI for CD patients was 30.5 ± 10, and UC disease activity index of 2.5 ± 2 for UC. By start of IBDC, all patients were in remission, although at end 1 each of UC and CD had active disease. The mean IMPACT score at start of the IBDC for those with inactive disease throughout was 161 ± 12, and 164 ± 9 at study completion. For those with active disease at study completion, the values were 138 ± 37 and 140 ± 30 respectively. Disease-related knowledge, as measured by IBD-KID, was 15 ± 5 at entry into IBDC, and 17 ± 4 at completion. Satisfaction questionnaires completed by patients and parents uniformly provided strongly positive endorsements of the program, although debriefing at study completion raised issues about appeal of computer game. Conclusions: Participants were uniformly and strongly supportive of the IBDC intervention. Preliminary results show positive trends, but final results for all 40 patient/parent dyads are required to assess the true impact on QOL and other outcomes of this innovative intervention.