Aims: This study aims to examine the psychological impact of family separation on Overseas Filipino Workers (OFWs) and their children, with a focus on emotional distress, coping strategies, and the long-term effects of prolonged separation on family dynamics. Sample: The study involved 50 OFW parents residing in Dubai and 50 of their children aged 8-18 living in the Philippines, providing a dual perspective on the experiences of both parents and children. Study Design: A mixed-methods research design was utilized, integrating both quantitative and qualitative approaches to offer a comprehensive understanding of the psychological impacts of family separation. Place and Duration of Study: Data were collected between January and August 2024, with participants recruited through community organizations supporting OFWs in Dubai. Methodology: Quantitative data were collected using the Depression, Anxiety, and Stress Scale (DASS-21) and the Emotional Regulation Questionnaire (ERQ). Semi-structured interviews provided qualitative insights into emotional experiences, coping mechanisms, and the challenges of reintegration. Statistical analyses explored correlations between separation duration, communication frequency, and psychological distress. Results: Quantitative findings from the ANOVA revealed that OFW parents had a significantly higher mean depression score (16.3, SD = 5.4) compared to their children (14.4, SD = 4.2), F (1, 98) = 4.21, p < 0.05. Anxiety levels were similarly elevated in both parents (18.1, SD = 6.2) and children (18.6, SD = 5.7), with no significant difference, F (1, 98) = 0.12, p > 0.05. A positive correlation (p < 0.01) was found between the length of separation (average 3.5 years) and psychological distress. Frequent communication was associated with lower anxiety levels (p < 0.01). Qualitative analysis identified seven key themes: emotional burden of separation, coping strategies, impact on family dynamics, reintegration challenges, mental health and well-being, support systems, and emotional regulation. Parents expressed regret over missing family milestones, while children reported feelings of abandonment. Some families, however, demonstrated resilience through strong communication practices and emotional regulation skills. Conclusion: The study underscores the urgent need for comprehensive mental health interventions that address the psychological challenges experienced by OFW families. Emotional support systems, in addition to financial assistance, are essential to mitigating the emotional toll of prolonged separation and fostering healthier family dynamics.