Support For Repression Research Articles

Epigenetic and post-transcriptional repression support metabolic suppression in chronically hypoxic goldfish

Goldfish enter a hypometabolic state to survive chronic hypoxia. We recently described tissue-specific contributions of membrane lipid composition remodeling and mitochondrial function to metabolic suppression across different goldfish tissues. However, the molecular and especially epigenetic foundations of hypoxia tolerance in goldfish under metabolic suppression are not well understood. Here we show that components of the molecular oxygen-sensing machinery are robustly activated across tissues irrespective of hypoxia duration. Induction of gene expression of enzymes involved in DNA methylation turnover and microRNA biogenesis suggest a role for epigenetic transcriptional and post-transcriptional suppression of gene expression in the hypoxia-acclimated brain. Conversely, mechanistic target of rapamycin-dependent translational machinery activity is not reduced in liver and white muscle, suggesting this pathway does not contribute to lowering cellular energy expenditure. Finally, molecular evidence supports previously reported chronic hypoxia-dependent changes in membrane cholesterol, lipid metabolism and mitochondrial function via changes in transcripts involved in cholesterol biosynthesis, β-oxidation, and mitochondrial fusion in multiple tissues. Overall, this study shows that chronic hypoxia robustly induces expression of oxygen-sensing machinery across tissues, induces repressive transcriptional and post-transcriptional epigenetic marks especially in the chronic hypoxia-acclimated brain and supports a role for membrane remodeling and mitochondrial function and dynamics in promoting metabolic suppression.

Cultures of conflict: Protests, violent repression, and community values.

What are the cultural origins of societal conflicts that revolve around democratization, women's rights, and modern libertarian values? We propose that deep‐seated differences in community‐based collective values (at the micro‐level) may be related to why people support anti‐government protest and why they support repression of such protests (at the macro‐level). The hypothesis was examined among residents of Turkey (N = 500). Cultural values, measured at the individual level and community level with the community collectivism scale, correlated with political orientation and emotions, as well as with subsequent support for anti‐governmental protest or its repression. The main conclusions are that both support for protest and support for repression are related to the cultural values people hold and their subsequent political orientations and emotions. Micro‐level cultural values in local communities may thus play a role in explaining macro‐level socio‐political divides.

Rehabilitation and Repression

For over a century, scholars and practitioners have assumed rehabilitation stands as the progressiveopposite of repression. Elaborating on previous warnings and anomalous findings, a representativesurvey of the Dutch population (N = 1,892) points out that this received view is flawed. Whenmeasured separately, no significant correlation exists between support for rehabilitation and supportfor repression, rehabilitation is equally popular among the constituencies of conservative andprogressive political parties, and no negative relationship exists be tween rehabilita tion and author-itarianism. Decriminalization rather than rehabilitation proves to constitute the progressive converseof repression. By way of conclusion, we discuss the remarkable persistence of the received view reas-sessed in this paper, even in the face of convincing earlier contradictory evidence.