Every organization typically comprises various internal components, including regional branches, operations centers/field offices, major transportation hubs, and operational units, among others, housing a population susceptible to disaster impacts. Moreover, organizations often possess resources such as staff, various vehicles, and medical facilities, which can mitigate human casualties and address needs across affected areas. However, despite the importance of managing disasters within organizational networks, there remains a research gap in the development of mathematical models for such scenarios, specifically incorporating operations centers/field offices and external stakeholders as relief centers. Addressing this gap, this study examines an optimization model for both before and after disaster planning in a humanitarian supply chain and logistical framework within an organization. The affected areas are defined as regional branches, operational units, major transportation hubs, operations centers/field offices, external stakeholders, and medical facilities. A mixed-integer nonlinear model is formulated to minimize overall costs, considering factors such as penalty costs for untreated injuries and demand, delays in rescue and relief item distribution operations, and waiting costs for the injured in emergency medical vehicles and air ambulances. The model is implemented using GAMS software 47.1.0 for various test problems across different scales, with the Grasshopper Optimization Algorithm proposed for larger-scale scenarios. Numerical examples are provided to show the effectiveness and feasibility of the proposed model and to validate the metaheuristic approach. Sensitivity analysis is conducted to assess the model’s performance under different conditions, and key managerial insights and implications are discussed.