Superior Activity Research Articles

Design, synthesis, and antibacterial activity of pleuromutilin derivatives.

This paper reports the design, synthesis, and antibacterial activity study of pleuromutilin derivatives with 2-methyl-4-nitroaniline and 2-methoxy-4-nitroaniline side chains at the C22 position. The structures of the new compounds were characterized by 1H-NMR, 13C-NMR and HRMS. The inhibitory activity of the compounds against MSSA, pyogeniccoccus, streptococcus, and MRSA strains was determined using the micro broth dilution method. The results showed that the compounds exhibited certain activity against Gram-positive bacteria, among which compounds A8a, A8b, A8c, A8d, and A7 demonstrated superior antibacterial activity against MSSA, MRSA, and pyogeniccoccus compared to tiamulin, although the derivatives showed lower antibacterial activity against streptococcus compared to the control drug. Based on the favorable invitro activity of A8c, the time-kill kinetics against MRSA were evaluated, revealing that compound A8c could inhibit bacterial proliferation in a concentration-dependent manner.

Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins

Although three generations of Epidermal growth factor receptor (EGFR) - TK inhibitors have been approved for the treatment of Non-small-cell lung cancers (NSCLC), their clinical application is still largely hindered by acquired drug resistance mediated new EGFR mutations and side effects. The Proteolysis targeting chimera (PROTAC) technology has the potential to overcome acquired resistance from mutant EGFR through a novel mechanism of action. In this study, we developed the candidate degrader IV-3 by structural modifications of the lead compound 13, which exhibited limited antiproliferative activity against HCC-827 cells. Compared to compound 13, IV-3 exhibited remarkable anti-proliferative activity against HCC-827 cells, NCI–H1975 cells, and NCI–H1975-TM cells (IC50 = 0.009 μM, 0.49 μM and 3.24 μM, respectively), as well as significantly inducing degradation of EGFR protein in these cell lines (DC50 = 17.93 nM, 0.25 μM and 0.63 μM, respectively). Further investigations confirmed that IV-3 exhibited superior anti-tumor activity in all xenograft tumor models through the degradation of mutant EGFR protein. Moreover, IV-3 showed no inhibitory activity against A431 and A549 cells expressing wild-type EGFR, thereby eliminating potential toxic side effects emerging from wild-type EGFR inhibition. Overall, our study provides promising insights into EGFR-PROTACs as a potential therapeutic strategy against EGFR-acquired mutation.

Sputter Deposited Crystalline MoO2 Films as a High-Capacity and Stable Electrode Material for Supercapacitors: Mechanistic/Electrochemical Insights

In this work, we have optimized and fabricated pristine molybdenum dioxide (MoO2) electrodes over the Silicon (Si) substrate and examined the impact of various ion-loaded aqueous electrolytes on their electrochemical behavior. The sputtered electrodes exhibited a high crystalline structure and a very low resistivity. These highly conductive electrodes were tested in three different aqueous electrolytes (acidic, neutral, and alkaline) to establish a relation between the electrode and the nature of the electrolyte to achieve optimal electrochemical performance and cyclability. The electrochemical kinetics showed that the charge storage mechanism was unique for all the electrolytes. The capacitive current was dominant in the neutral electrolyte, whereas it was diffusive dominant in alkaline and 70% capacitive in the acidic electrolyte. Our findings indicated that the MoO2@Si electrode exhibited superior electrochemical activity in an acidic electrolyte. The electrode showed a voltage window of 0.6 V with an areal capacity of 24 mF/cm2 at 0.1 V/s scan rate. Moreover, the electrode also demonstrated excellent cyclability and capacitance retention (∼145%) till 5000 cycles. These results highlighted that the binder-free MoO2@Si electrode showed outstanding electrochemical activity and stability, which makes it suitable for sulfuric acid electrolyte-based energy storage systems.

In situ construction of layered transition metal phosphides/sulfides heterostructures for efficient hydrogen evolution in acidic and alkaline media

Construction of electrocatalysts with exceptional intrinsic activity and rich active sites has proved to be an effective strategy for remarkably enhancing the activity of the hydrogen evolution reaction (HER). In this work, durable and highly efficient layered Re2P/ReS2 (RePS) heterostructures were successfully fabricated by an in-situ phosphating layered ReS2. Taking advantage of the unique layered structure can provide abundant reaction active sites and the strong electronic interaction between ReS2 and Re2P can enhance the intrinsic activity, the optimized RePS electrocatalysts show superior catalytic activities of 69 and 57 mV at 10 mA cm−2 for HER in alkaline and acidic media, respectively. The density functional theory results suggest that the formed heterostructures between ReS2 and Re2P play an important role in optimizing the catalytic kinetics of the electrocatalysts. This work not only demonstrates that modulation of the electronic structure of catalysts is an efficient way to improve the HER activity but also confirms that the layered RePS heterostructure is a promising candidate for robust and high performance HER catalysts.

Flotation activation mechanism of trithiocyanuric acid to malachite

Malachite is a typical refractory copper oxide mineral. In this paper, trithiocyanuric acid (TMT) was used as a novel activator for the activated flotation of malachite for the first time. The effect of TMT on the flotation behavior of malachite was studied and the activation mechanism was discussed. The flotation test results showed that TMT exhibited superior activation performance over sodium sulfide, achieving a high flotation recovery rate of 97.50 % at TMT 90 mg/L and pH 7. The contact angle confirmed malachite improved from 53.3° to 90.1° after TMT treatment, indicating enhanced hydrophobicity of the mineral surface. FTIR and EDS analyses provided clear evidence of chemical adsorption of TMT tautomers onto the malachite surface. SEM images further illustrated the presence of dense particles formed after TMT treatment. XPS revealed that TMT exhibited a strong adsorption effect on malachite, leading to an increase in copper sites and the formation of highly reactive Cu+. The activation mechanism was elucidated as the reaction between Cu sites on malachite and S and N atoms in TMT, forming Cu-S and Cu–N fractions crucial for activation. The high efficiency and low dosage of TMT make it a promising activator for malachite, offering a novel avenue for the effective recovery of malachite-type copper oxide ore resources.

Ultrathin 2D Alloyed Cu−Ga−Zn−S Curved Nanobelts for Boosting Visible‐Light Photocatalytic Hydrogen Evolution

Abstract2D semiconductor nanomaterials have received significant attention as photocatalysts for solar‐to‐hydrogen conversion due to their robust light absorption capacity, large specific surface area, and superior electron transport characteristics. Nevertheless, it is challenging to develop 2D quaternary copper‐based sulfides (QCSs) with functional integration of conducive structural features for photocatalysis from multiple elements and intricate control conditions. Herein, ultrathin 2D alloyed Cu−Ga−Zn−S (CGZS) curved nanobelts (NBs) are fabricated by using a facile one‐pot colloidal method. Subsequently, the derived Cu31S16‐CGZS Janus heterostructures are designed by increasing Cu concentrations. The formation mechanism of 2D curved alloys and Janus heterostructures is systematically investigated. Without cocatalysts, curved alloyed CGZS NBs demonstrated superior photocatalytic activities of 1264.2 µmol g−1 h−1 compared to Janus heterostructured Cu31S16−CGZS (463.1 µmol g−1 h−1) under visible light (> 400 nm). Experimental and theoretical results unveiled that the improved photocatalytic activities of curved CGZS NBs can be attributed to enhanced charge–carrier separation efficiency resulting from high crystallinity and ultrathin 2D structure, abundant active sites from curved structure, high‐active (0001) crystal facet with the lowest reaction Gibbs energy, work function, and metal‐like properties. This work offers new insights into functional integration into ultrathin 2D QCSs with enhanced visible‐light photocatalytic performance.

Biogenic synthesis of CoO and ZnO nanoparticles using rosemary extract: Synergistic antimicrobial activity and insights from DFT simulations

Plant extracts with stabilizing and emulsifying qualities are commonly used in nanotechnology for the eco-friendly production of metallic nanoparticles. The study focused on synthesizing CoO and ZnO nanoparticles by the use of rosemary leaf extract. Quantum chemical calculations were performed using the DFT method to determine the active sites of the main chemical compounds in rosemary extract that catalyze the bi-reduction of Co+2 and Zn+2, resulting in the eco-friendly production of CoO and ZnO nanoparticles. Rosemary leaf extracts include a significant quantity of hydroxyl groups (–OH), oxygen atoms as heteroatoms, and many aromatic rings. The enhanced amount of π-electrons, resulting from aromatic rings and electron-releasing groups connected to these rings, facilitates the simultaneous reduction of Co and Zn metals. This happens because the π-electrons are more likely to interact with the vacant d-orbitals of Co and Zn. Antibacterial activity tests show that CoO and ZnO nanoparticles manufactured using green methods are effective against both gram-negative and gram-positive bacteria, as well as the fungal isolate C. albicans with superior activity of CoO nanoparticles. The MIC assay results show that the synthesized nanoparticles are more effective against gram-negative E. coli bacteria than gram-positive S. aureus bacteria and C. albicans. CoO nanoparticles showed about 1.5x - 3x fold more antibacterial activity compared to ZnO nanoparticles. The results emphasize the possibility of using green synthesis of nanoparticles as an environmentally benign and cost-efficient technique for mass manufacturing, showing potential applications in the fields of medicine and industry.

Synergistic Bulk and Surface Engineering for Expeditious and Durable Reversible Protonic Ceramic Electrochemical Cells Air Electrode.

Reversible protonic ceramic electrochemical cells (R-PCECs) offer the potential for high-efficiency power generation and green hydrogen production at intermediate temperatures. However, the commercial viability of R-PCECs is hampered by the sluggish kinetics of the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) within conventional air electrodes operating at reduced temperatures. To address this challenge, we introduce a novel approach based on the simultaneous optimization of bulk-phase metal-oxygen bonds and in-situ formation of a metal oxide nano-catalyst surface modification. This strategy is designed to expedite the ORR/OER electrocatalytic activity of air electrodes exhibiting triple (O2-, H+, e-) conductivity. Specifically, our engineered air electrode nanocomposite-Ba(Co0.4Fe0.4Zr0.1Y0.1)0.95Ni0.05F0.1O2.9-δ demonstrates remarkable ORR/OER catalytic activity and exceptional durability in R-PCECs. This is evidenced by significantly improved peak power density from 626mW cm-2 to 996mW cm-2 and highly stable reversibility over a 100-hour cycling period. This research offers a rational design strategy to achieve high-performance R-PCEC air electrodes with superior operational activity and stability for efficient and sustainable energy conversion and storage. This article is protected by copyright. All rights reserved.

A Highly Reversible Sn-Air Battery Possessing the Ultra-LowCharging Potential with the Assistance of Light.

Aqueous Sn-air batteries are attracting a great deal of interest in recent years due to the ultra-high safety, low cost, dendrite-free and highly reversible Sn anode. However, the slurry oxygen reduction/evolution reaction (ORR/OER) kinetics on the air cathodes seriously affect the Sn-air battery performances. Although various advanced catalysts have been developed, the charge overpotentials (~1000 mV) of these Sn-air batteries are still not satisfactory. Herein, iron oxide (Fe2O3) modified titanium dioxide (TiO2) nanorods with heterogeneous structure are firstly synthesized on Ti mesh (Fe2O3@TiO2/Ti), and the obtained Fe2O3@TiO2/Ti is further applied as catalytic electrodes for Sn-air batteries. The core-shell heterogeneous structure of Fe2O3@TiO2/Ti can effectively facilitate the conversion of electrochemical intermediates and separation of photo-excited electrons and holes to active oxygen-related reaction processes. DFT and experimental results also confirm that Fe2O3@TiO2/Ti can not only act as the electrocatalysts to improve ORR/OER properties, but also exhibit the superior photo-catalytic activity to promote charge kinetics. Hence, the Fe2O3@TiO2/Ti-based Sn-air batteries show ultra-low overpotential of ~40 mV, excellent rate capability and good cycling stability under light irradiation. This work will shed light on rational photo-assisted catalytic cathode design for new-type metal-air batteries.

Efficient Electrosynthesis of Urea over Single-Atom Alloy with Electronic Metal Support Interaction.

Urea electrosynthesis from carbon dioxide (CO2) and nitrate (NO3-) is an alternative approach to traditional energy-intensive urea synthesis technology. Herein, we report a CuAu single-atom alloy (SAA) with electronic metal support interaction (EMSI), achieving a high urea yield rate of 813.6 μg h-1 mgcat-1 at -0.94 V versus reversible hydrogen electrode (vs. RHE) and a Faradaic efficiency (FE) of 45.2% at -0.74 V vs. RHE. In-situ experiments and theoretical calculations demonstrated that single-atom Cu sites modulate the adsorption behavior of intermediate species. Bimetallic sites synergistically accelerate C-N bond formation through spontaneous coupling of *CO and *NO to form *ONCO as key intermediates. More importantly, electronic metal support interaction between CuAu SAA and CeO2 carrier further modulates electron structure and interfacial microenvironment, endowing electrocatalysts with superior activity and durability. This work constructs SAA electrocatalysts with EMSI effect to tailor C-N coupling at the atomic level, which can provide guidance for the development of C-N coupling systems.

Efficient Electrosynthesis of Urea over Single‐Atom Alloy with Electronic Metal Support Interaction

Urea electrosynthesis from carbon dioxide (CO2) and nitrate (NO3−) is an alternative approach to traditional energy‐intensive urea synthesis technology. Herein, we report a CuAu single‐atom alloy (SAA) with electronic metal support interaction (EMSI), achieving a high urea yield rate of 813.6 μg h−1 mgcat−1 at –0.94 V versus reversible hydrogen electrode (vs. RHE) and a Faradaic efficiency (FE) of 45.2% at –0.74 V vs. RHE. In‐situ experiments and theoretical calculations demonstrated that single‐atom Cu sites modulate the adsorption behavior of intermediate species. Bimetallic sites synergistically accelerate C‐N bond formation through spontaneous coupling of *CO and *NO to form *ONCO as key intermediates. More importantly, electronic metal support interaction between CuAu SAA and CeO2 carrier further modulates electron structure and interfacial microenvironment, endowing electrocatalysts with superior activity and durability. This work constructs SAA electrocatalysts with EMSI effect to tailor C‐N coupling at the atomic level, which can provide guidance for the development of C‐N coupling systems.

Role of Morphology in Improving the Catalytic Performance of ZnCo2O4 for Soot Oxidation

Abstract The extent of interaction between carbon and catalyst profoundly shapes soot oxidation results. The catalyst configuration notably influences the frequency of contact points in solid-solid interactions. This investigation studies the impact of three distinct ZnCo22O4 catalyst morphologies and their redox property on soot oxidation. The formation of the cubic phase of ZnCo2O4via three distinct methods was revealed during XRD analysis. SEM analysis unveiled varying morphologies, including rod-shaped, rose petal-shaped, and bead-like structures. Notably, ZnCo2O4 exhibiting bead-like morphology demonstrated heightened levels of chemisorbed oxygen species which was observed during XPS analysis. The presence of Co2+ and Co3+ occupied at octahedral site ZnCo2O4 acted as the active sites for soot oxidation. With continuous redox property (Co 3+ → Co2+) leading to the generation of active oxygen species and with an added advantage of surface morphology, the M2 sample (with bead-like morphology) exhibited superior soot oxidation activity, which is evident by its T50% value of 402°C. This study underscores the essential role of catalyst morphology in influencing soot oxidation activity. Through a comprehensive array of structural, morphological, and catalytic analyses, this work sheds light on the correlation between catalyst architecture and enhanced soot oxidation performance.

Origin of the Activity of Electrochemical Ozone Production over Rutile PbO2 Surfaces.

Ozonation water treatment technology has attracted increasing attention due to its environmental benign and high efficiency. Rutile PbO2 is a promising anode material for electrochemical ozone production (EOP). However, the reaction mechanism underlying ozone production catalyzed by PbO2 was rarely studied and not well-understood, which was in part due to the overlook of the electrochemistry-driven formation of oxygen vacancy (OV) of PbO2. Herein, we unrevealed the origin of the EOP activity of PbO2 starting from the electrochemical surface state analysis using density functional theory (DFT) calculations, activity analysis, and catalytic volcano modeling. Interestingly, we found that under experimental EOP potential (i.e., a potential around 2.2 V vs. reversible hydrogen electrode), OV can still be generated easily on PbO2 surfaces. Our subsequent kinetic and thermodynamic analyses show that these OV sites on PbO2 surfaces are highly active for the EOP reaction through an interesting atomic oxygen (O*)-O2 coupled mechanism. In particular, rutile PbO2(101) with the "in-situ" generated OV exhibited superior EOP activities, outperforming (111) and(110). Finally, by catalytic modeling, we found that PbO2 is close to the theoretical optimum of the reaction, suggesting a superior EOP performance of rutile PbO2. All these analyses are in good agreement with experimental observations.

Antimicrobial Solid Starch–Iodine Complex via Reactive Extrusion and Its Application in PLA-PBAT Blown Films

In this study, a solid masterbatch of starch–iodine complex with 6.7 wt.% iodine was prepared in pellet form using a ZSK-30 twin-screw extruder. Thermogravimetric (TGA) and isothermal TGA analysis of the pellets revealed that there was no significant loss of iodine due to sublimation during reactive extrusion. These solid pellets demonstrated antifungal properties when applied to strawberries via dip coating in an aqueous solution, extending their shelf life from two days to eight days, thereby reducing fungal growth and visual decay. Furthermore, the solid pellets displayed antibacterial activity against E. coli, as evidenced by the clear zone of inhibition observed in the Kirby–Bauer test. To enhance practical application, these pellets were further blended with PLA-PBAT film formulations at 10 and 18% by wt. to make blown films with effective iodine loadings of 0.7 and 1.3% by wt. These films showed superior antibacterial activity against E. coli compared with PLA control films and the commercial silver antimicrobial-containing films during direct inoculation tests as per ISO 22196. Tensile strength and elongation at break in machine direction (MD) for the starch–iodine-containing blown films were comparable to the control films in MD, but tensile strength was reduced to 37–40% in the transverse direction (TD). This was due to a non-uniform dispersion of the starch–iodine complex in the films, as confirmed by the visual and SEM analyses. Thus, this study illustrates the practical utility of the solid starch–iodine complex as a safe and efficient means of introducing iodine into an environment, mitigating the typical hazards associated with handling solid iodine.

Recent progresses in synthesis and modification of g-C3N4 for improving visible-light-driven photocatalytic degradation of antibiotics

ABSTRACT Graphitic carbon nitride (g-C3N4) is a widely studied visible-light-active photocatalyst for low cost, non-toxicity, and facile synthesis. Nonetheless, its photocatalytic efficiency is below par, due to fast recombination of charge carriers, low surface area, and insufficient visible light absorption. Thus, the research on the modification of g-C3N4 targeting at enhanced photocatalytic performance has attracted extensive interest. A considerable amount of review articles have been published on the modification of g-C3N4 for applications. However, limited effort has been specially contributed to providing an overview and comparison on available modification strategies for improved photocatalytic activity of g-C3N4-based catalysts in antibiotics removal. There has been no attempt on the comparison of photocatalytic performances in antibiotics removal between modified g-C3N4 and other known catalysts. To address these, our study reviewed strategies that have been reported to modify g-C3N4, including metal/non-metal doping, defect tuning, structural engineering, heterostructure formation, etc. as well as compared their performances for antibiotics removal. The heterostructure formation was the most widely studied and promising route to modify g-C3N4 with superior activity. As compared to other known photocatalysts, the heterojunction g-C3N4 showed competitive performances in degradation of selected antibiotics. Related mechanisms were discussed, and finally, we revealed current challenges in practical application.

M−N3 Configuration on Boron Nitride Boosts Singlet Oxygen Generation via Peroxymonosulfate Activation for Selective Oxidation

AbstractSinglet oxygen (1O2) is an essential reactive species responsible for selective oxidation of organic matter, especially in Fenton‐like processes. However, due to the great limitations in synthesizing catalysts with well‐defined active sites, the controllable production and practical application of 1O2 remain challenging. Herein, guided by theoretical simulations, a series of boron nitride‐based single‐atom catalysts (BvBN/M, M=Co, Fe, Cu, Ni and Mn) were synthesized to regulate 1O2 generation by activating peroxymonosulfate (PMS). All the fabricated BvBN/M catalysts with explicit M−N3 sites promoted the self‐decomposition of the two PMS molecules to generate 1O2 with high selectivity, where BvBN/Co possessed moderate adsorption energy and d‐band center exhibited superior catalytic activity. As an outcome, the BvBN/Co‐PMS system coupled with membrane filtration technology could continuously transform aromatic alcohols to aldehydes with nearly 100 % selectivity and conversion rate under mild conditions, suggesting the potential of this novel catalytic system for green organic synthesis.

Machine Learning Molecular Dynamics Shows Anomalous Entropic Effect on Catalysis through Surface Pre‐melting of Nanoclusters

AbstractDue to the superior catalytic activity and efficient utilization of noble metals, nanocatalysts are extensively used in the modern industrial production of chemicals. The surface structures of these materials are significantly influenced by reactive adsorbates, leading to dynamic behavior under experimental conditions. The dynamic nature poses significant challenges in studying the structure–activity relations of catalysts. Herein, we unveil an anomalous entropic effect on catalysis via surface pre‐melting of nanoclusters through machine learning accelerated molecular dynamics and free energy calculation. We find that due to the pre‐melting of shell atoms, there exists a non‐linear variation in the catalytic activity of the nanoclusters with temperature. Consequently, two notable changes in catalyst activity occur at the respective temperatures of melting for the shell and core atoms. We further study the nanoclusters with surface point defects, i.e. vacancy and ad‐atom, and observe significant decrease in the surface melting temperatures of the nanoclusters, enabling the reaction to take place under more favorable and milder conditions. These findings not only provide novel insights into dynamic catalysis of nanoclusters but also offer new understanding of the role of point defects in catalytic processes.

A Coupled System of Ni3S2 and Rh Complex with Biomimetic Function for Electrocatalytic 1,4-NAD(P)H Regeneration.

NAD(P)H cofactor is a critical energy and electron carrier in biocatalysis and photosynthesis, but the artificial reduction of NAD(P)+ to regenerate bioactive 1,4-NAD(P)H with both high activity and selectivity is challenging. Herein, we found that a coupled system of a Ni3S2 electrode and a Rh complex in an electrolyte (denoted as Ni3S2-Rh) can catalyze the reduction of NAD(P)+ to 1,4-NAD(P)H with superior activity and selectivity. The optimized selectivity in 1,4-NADH can be up to 99.1%, much higher than that for Ni3S2 (80%); the normalized activity of Ni3S2-Rh is about 5.8 times that of Ni3S2 and 13.2 times that of the Rh complex. The high performance of Ni3S2-Rh is attributed to the synergistic effect between metal sulfides and Rh complex. The NAD+ reduction reaction proceeds via a concerted electron-proton transfer (CEPT) mechanism in the Ni3S2-Rh system, in which Ni3S2 acts as a proton and electron-transfer mediator to accelerate the formation of Rh hydride (Rh-H), and then the Rh-H regioselectively transfers the hydride to NAD+ to form 1,4-NADH. The artificial system Ni3S2-Rh essentially mimics the functions of ferredoxin-NADP+ reductase in nature.

Interface engineering of MoS2–CoS2 heteronanosheets for enhanced electrochemical hydrogen evolution reaction

The heterostructured electrocatalysts with tunable electronic interaction and distinct synergetic effects have been confirmed as an efficient strategy for realizing high-performance hydrogen evolution reaction (HER). Herein, a simple synthetic strategy is reported for the growth of MoS2–CoS2 nanosheets on highly conductive reduced graphene oxide (MoS2–CoS2/RGO) to innovatively construct an electron-reconfiguration heterointerface. The strong electronic interactions between MoS2 and CoS2 interfaces lead to the redistribution of charge, which optimizes the adsorption-desorption of intermediates. Thus, the MoS2–CoS2/RGO exhibits superior catalytic activity toward HER with small overpotentials of 67 mV (1.0 M KOH) and 95 mV (0.5 M H2SO4), and remarkable stability. In addition, theoretical calculations reveal the redistribution of charge at the heterointerfaces, which decreases the energy barrier of adsorption for H intermediates and simultaneously enhances the kinetic of water dissociation. This work provides a simple strategy for designing heterostructured bimetallic electrocatalysts with a highly active interface.

Implantable patch of oxidized nanofibrillated cellulose and lysozyme amyloid nanofibrils for the regeneration of infarcted myocardium tissue and local delivery of RNA-loaded nanoparticles.

Biopolymeric implantable patches are popular scaffolds for myocardial regeneration applications. Besides being biocompatible, they can be tailored to have required properties and functionalities for this application. Recently, fibrillar biobased nanostructures proved to be valuable in the development of functional biomaterials for tissue regeneration applications. Here, periodate-oxidized nanofibrillated cellulose (OxNFC) was blended with lysozyme amyloid nanofibrils (LNFs) to prepare a self-crosslinkable patch for myocardial implantation. The OxNFC:LNFs patch showed superior wet mechanical properties (60MPa for Young's modulus, and 1.5MPa for tensile stress at tensile strength), antioxidant activity (70% scavenging activity under 24h), and bioresorbability ratio (80% under 91 d), when compared to the patches composed solely of NFC or OxNFC. These improvements are achieved while preserving the morphology, required thermal stability for sterilization, and biocompatibility towards rat cardiomyoblast (H9c2) cells. Additionally, both OxNFC and OxNFC:LNFs patches reveal the ability to act as efficient vehicles to deliver spermine (Sp) modified acetalated dextran nanoparticles (Sp-AcDEX NPs), loaded with small interfering RNA (siRNA), with 80% of delivery after 5 d. This study highlights the value of simply blending OxNFC and LNFs, synergistically combining their key properties and functionalities, resulting in a biopolymeric patch that comprises valuable characteristics for myocardial regeneration applications. This article is protected by copyright. All rights reserved.