This study involves an investigation on fully evaporation process inside annular porous heat exchanger using Cu/distilled water nano-fluid. Emphasis has been placed on how the use of Cu/distilled water affected two-stage flux predictions. Two-phase mixture model, based on the considerations of Local Thermal Equilibrium (LTE), has been reformulated to involve the influences of employing nano-fluid instead of only water. To display the actions of employing nano-fluid, the predictions of liquid saturation and temperature, obtained using Cu/distilled water and only water, have been presented and compared for a wide ranges of geometric conditions, operating conditions and properties of porous media. The outcomes displayed that the using Cu particle to water has a large impacts on the heat diffusivity, where the boiling and condensation fronts are considerably moved to downstream and upstream sections, respectively, as compared to the predictions of only water due to rising the axial diffusion. The temperature at the pipe exit is considerably decreased when adding Cu particles to water as compared to the pure water case. The predications of Cu/distilled water show that the nano-fluid volume fraction, geometric parameters, operating parameters and porous structure properties have high actions on the locations of initiation and termination of phase change process. Since the fluid temperature for pure water case is extremely high at the superheated vapour region, the addition of Cu particles to water considerably reduces the fluid temperature in this region and hence, the use of nano-fluid can be considered as a safety factor in the applications that used heat exchangers (boiling processes) due to it improves the mechanism of heat transfer during the boiling process.