In this article, we consider the following fractional (p,q)-Laplacian problem (−Δ)ps1u+(−Δ)qs2u+V(x)(|u|p−2u+|u|q−2u)=f(u)+λ|u|r−2u, where x∈RN, (−Δ)ps1 is the fractional p-Laplacian operator ((−Δ)qs2 is similar), 0<s1<s2<1<p<q<Ns2, qs2*=NqN−s2q, r≥qs2*, f is a C1 real function and V is a coercive function. By using variational methods, we prove that the above problem admits a sign-changing solution if λ>0 is small.