The prospects to study hyperon-nucleus/nucleon interactions at BESIII and similar colliders are analyzed in this paper. Utilizing the large quantity of hyperons produced by the decay of 10 billion and 2.7 billion collected at BESIII, the cross sections of several specific elastic and inelastic hyperon-nucleus reactions can be measured via scattering between hyperons and nucleus in the dense objects of the BESIII detector. Subsequently, the cross sections of the corresponding hyperon-nucleon interactions can be extracted from further phenomenological calculations. The interactions between antihyperons and nucleus/nucleon, including scattering and annihilation, can also be studied using the method proposed in this study. The results will definitely benefit the realization of precise probes for hyperon-nuclei/nucleus interactions and establish constraints to study the potential of strong interaction, the origin of color confinement, a unified model for baryon-baryon interactions, and the internal structure of neutron stars. In addition, the desirable prospects of corresponding studies in the future Super Tau-Charm Factory (STCF) are discussed and estimated in this study.
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