The aim of this study is to numerically investigate the effect of bed slope on the hydraulic performance of side weirs in supercritical and subcritical flow regimes. Increasing the bed slope decreases the weir efficiency and discharge coefficient in the subcritical flow regime up to 14.54% and in the supercritical flow regime up to 9.26%. By examining the longitudinal velocity distribution, it was observed that in the subcritical flow regime, the maximum longitudinal velocity occurs at the beginning of the upstream of the side weir, and by moving towards the downstream of the weir, the flow velocity decreases and increases again after leaving the length of the weir. In the supercritical flow regime, it has an increasing trend when the flow enters from the upstream of the side weir. The increase in discharge coefficient with the increase of the weir height varied between 4.6% and 7.8%. With increase of the slope of the channel bed, the velocity along the length of the weir increases by 10.88% and 6.17%, respectively, in the subcritical and supercritical regimes, and the transverse velocity along the transverse direction for the subcritical and supercritical flow regimes decreased by 22.23% and 4.80%, respectively.