The annual changes of sediment deposition-scour on the riverbed in the Sanhuhekou-Toudaoguai Reach of the upper Yellow River during the years 1952–2010 were investigated based on runoff and sediment transport observations from the Sanhuhekou and Toudaoguai hydrological stations. Multiple influencing factors such as reservoir operations, tributary inflows, as well as runoff and sediment loads from the Shidakongdui area were analyzed. The results show that even though the sediment loads from the major sources, the Shidakongdui area as well as the upstream tributaries such as the Qingshui River and the Zuli River have reduced especially since the 2000s as a result of enhanced water-soil conservation measures and improvement of vegetation cover, the study reach was still generally in a status of cumulative aggradation. This is mainly due to the joint operations of the Liujiaxia Reservoir and the Longyangxia Reservoir, which significantly reduced the annual runoff and sediment loads at the Sanhuhekou Crosssection. The reservoirs also remarkably altered the summer flood characteristics of the study reach, inducing the shape of the annual flow curve changing from a ‘single-peak’ into a ‘double-peak’. These alternations sharply decreased the sediment transport capacity of flooding in the summer flood season which yields more than 90% of the sediment loads, leading to an unbalanced relation between the water and sediment. In addition, the estimated incoming sediment coefficient of the Sanhuhekou Crosssection ranged from 0.003 to 0.014 kg s/m6, of which 0.004 kg s/m6 was suggested as a rough critical value to determine the scour or deposition status of the study reach.