Sufficient Hydrophobicity Research Articles

Large-Scale Computational Screening-Aided Development of High-Performance Adsorbent for Simultaneous Capture of Aromatic Volatile Organic Compounds.

The development of an efficient adsorbent for the simultaneous capture of large amounts of benzene, toluene, ethylbenzene, and xylene isomers (BTEX) is an important and challenging issue. Here, through a stepwise screening of 10,142 metal-organic framework (MOF) structures from the computation-ready, experimental (CoRE) MOF database, 65 MOFs are proposed as promising adsorbent candidates for BTEX capture by considering the structures with accessible pore sizes for BTEX adsorption, sufficient hydrophobicity, high benzene selectivity (>0.2), and large total BTEX uptake (>3 mmol/g). Among the top-performing MOFs in terms of the BTEXmatrix (total BTEX uptake × benzene selectivity), EGUELUY01 was synthesized, and it exhibited large uptakes (≈5 mmol/g) for all BTEX components at concentrations of 1200-1500 ppm, which are superior to the BTEX uptake of the benchmark adsorbent, activated carbon. Moreover, some structure-property relationships required for BTEX adsorbents are provided through the obtained large-scale simulation data and machine learning analysis. The determined relationships will be useful for the future development of efficient BTEX adsorbents.

Design, synthesis, biological evaluation and docking study of some new aryl and heteroaryl thiomannosides as FimH antagonists

FimH is a mannose-recognizing lectin that is expressed by Escherichia coli guiding its ability to adhere and infect cells. It is involved in pathogenesis of urinary tract infections and Chron’s disease. Several X-ray structure-guided ligand design studies were extensively utilized in the discovery and optimization of small molecule aryl mannoside FimH antagonists. These antagonists retain key specific interactions of the mannose scaffolds with the FimH carbohydrate recognition domains. Thiomannosides are attractive and stable scaffolds, and this work reports the synthesis of some of their new aryl and heteroaryl derivatives as FimH antagonists. FimH-competitive binding assays as well as biofilm inhibition of the new compounds (24–32) were determined in comparison with the reference n-heptyl α-d-mannopyranoside (HM). The affinity among these compounds was found to be governed by the structure of the aryl and heteroarylf aglycones. Two compounds 31 and 32 revealed higher activity than HM. Molecular docking and total hydrophobic to topological polar surface area ratio calculations attributed to explain the obtained biological results. Finally, the SAR study suggested that introducing an aryl or heteroaryl aglycone of sufficient hydrophobicity and of proper orientation within the tyrosine binding site considerably enhance binding affinity. The potent and synthetically feasible FimH antagonists described herein hold potential as leads for the development of sensors for detection of E. coli and treatment of its diseases.

Zeolite enhances leaf photosynthesis and fruit quality in tomato through greenhouse CO2 enrichment

Elevated CO2 concentration has been widely acknowledged as a leading factor to global climate change, while deficient CO2 serves as a crucial limiting factor in modern greenhouse production. Harnessing the existing excessive CO2 to promote agriculture production is significant but filled with challenges. To this end, we proposed a concentration gradient-regulated CO2 enrichment system for capturing CO2 into greenhouses, which requires suitable CO2 sorbents with sufficient CO2 desorption capacity and high hydrophobicity at ambient temperature and pressure. Zeolites with different framework types and cations were detected by CO2 desorption and cyclic stability test under simulated agricultural production conditions. The results indicate that larger pore volume cooperated with higher Si/Al ratio and weaker alkali cations may be critical determinants for balancing high CO2 adsorption-desorption capacities and hydrophobicity in crop-cultivated environments. H-SSZ-13 zeolite is identified as the potential sorbents and exhibits exceptional CO2 release abilities and cyclic stability in tomato-grown environment. Long-term application of H-SSZ-13 zeolite to tomato plants significantly stimulated photosynthetic processes, particularly the Calvin-Benson cycle, culminating in notable improvements in plant growth, fruit yield and quality. This investigation provides a promising solution to develop a carbon-neutral CO2 enrichment system for both sustainable and productive greenhouse production.

Evaluation of Hydrophobic Attraction between Polystyrene Layer and Silanated Silica Surface by Atomic Force Microscopy

Abstract In this study, hydrophobic surfaces were prepared by depositing polystyrene (PS) on a glass substrate using three different methods to measure the interaction forces against a hydrophobized particle by atomic force microscopy. We found that smooth surfaces prepared by spin coating and living radical polymerization generated hydrophobic attraction, whereas uneven surfaces obtained by free radical polymerization produced only steric repulsion, even though they had sufficient hydrophobicity. Based on these results, the origin of the hydrophobic attraction was suggested.

A sustainable strategy for targeted extraction of thorium from radioactive waste leachate based on hydrophobic deep eutectic solvent

In this work, the new hydrophobic deep eutectic solvents (HDESs) based on 2-hexyldecanoic acid (HDA) as a hydrogen bond donor (HBD) were used to selectively enrich trace Th from radioactive waste leach solution. These HDESs are characterized by low toxicity, bio-friendliness, low viscosity and sufficient hydrophobicity. Compared with Al, Mg, Ca and RE, HDESs exhibited exceptional selectivity for Th extraction, along with high loading capacity, easy stripping and stable reusability. The mechanism of Th extraction by the HDES is a cation exchange reaction. Based on the thymol (TL):HDA (1:3) HDES, a short flow closed-loop recovery process of Th in the leach solution of radioactive waste residue was developed. After a single-step extraction, the extraction percentage (E%) of Th exceeded 98.0%, while the E% of other elements was less than 0.14%. After stripping, the concentration of Th in the concentrated solution reached 2.16 × 103 mg/L with a purity of 74.2%, which could be directly used for subsequent purification. By adjusting the pH to 4.00, the raffinate was used as a feed solution for RE elements recovery. The HDES-based extraction strategy for Th is simple, safe, efficient and environmentally friendly, providing a new idea for the recovery of radioactive waste residues.

Microporous chitosan/polyvinyl alcohol based active packaging materials with integrated gas-transmission, radiation-cooling, anti-microbial, and ultraviolet shielding features

Active packaging materials transform the packaging from a passive barrier to active control, responding to consumers' demand for safer, healthier, and higher quality food and prolonging the shelf life of foods. Herein, a novel microporous chitosan/polyvinyl alcohol (CS/PVA) based biodegradable active packaging material (microporous membrane doped with 0.3 wt% nanometer TiO2, referred as MT3) was nanoengineered with integrated gas transmission, radiation cooling, anti-microbial and quality control characteristics. The particle leaching method realized the on-demand microporous structure, enabling an impressive CO2 permeability. Furthermore, TiO2 nanoparticles were filled in MT3 as functional fillers to achieve good radiation cooling, anti-bacterial and ultraviolet shielding functions. In addition, MT3 exhibited the typical features of packaging materials, such as sufficient hydrophobicity and mechanical and barrier performances. Interestingly, the superficial temperature of MT3 reduced by ∼ 6.4 °C due to its excellent radiation-cooling properties under a sub-ambient atmosphere. Thus, the on-demand comprehensive material design enabled MT3 to exhibit an enhanced shelf life of 168 h, which is difficult to achieve with conventional preservative films at room temperature. These results encourage the further use of MT3 films as multi-functional active packaging materials. This study provides a green and feasible method for the production of promising active packaging functional materials, which can be widely used in fresh fruit and vegetable preservation packaging.

Nanoporous thin films of hydrophobic block copolymers enabled by selective swelling for membrane distillation

Membrane distillation (MD) is receiving growing interest because of its >99.9% salt rejection even with low-grade waste heat as the energy supply. However, MD membranes are prone to be wetted and usually require complicated modification strategies to gain sufficient hydrophobicity. In this work, we report a new type of MD membranes with hydrophobic films carrying pores in the ultrafiltration range as the separation layers. Such membranes are prepared by coating an A-B-A triblock copolymer polystyrene-block-polydimethylsiloxane-block-polystyrene (PS-b-PDMS-b-PS, further abbreviated as SDS) on the macroporous PVDF substrate, followed by soaking in alkanes to cavitate the SDS coating layers following the mechanism of selective swelling. The PDMS microdomains in the SDS layers are converted to interconnected nanopores, and the PDMS blocks are enriched along the pore walls and membrane surface, endowing the membranes with intrinsic hydrophobicity. Thus-prepared SDS membranes exhibit stable rejection to NaCl (>99.99%) and high permeate flux up to 32.8 kg m−2 h−1, better than most MD membranes with large pores in the microfiltration range. Moreover, the SDS membranes display excellent wetting resistance, good heat resistance, and long-term stability. This work provides a new strategy to prepare MD membranes enabled by selective swelling of hydrophobic block copolymers, and demonstrates the great potential of hydrophobic ultrafiltration membranes in the long-term use in membrane distillation.

An investigation into the use of xanthate, trithiocarbonate and thiourea collectors on the flotation of sperrylite (PtAs2)

Sperrylite contributes about 21% to the total platinum group minerals (PGMs) found in the Platreef ore deposit. The recovery of sperrylite by flotation has been shown to be poor and the reasons for this are not well understood. Xanthate collectors have been widely used in flotation of PGM ores, especially in the recovery of PGMs associated with base metal sulfides. However, previous studies have shown that these collectors are not as successful in recovering sperrylite. This study has compared the use of xanthates with collectors with different functional groups, increased dosages, as well as high ionic strength of process water on the floatability of sperrylite. The xanthate, trithiocarbonate and thiourea collectors investigated were shown to adsorb on sperrylite to varying degrees, but at a dosage equivalent to about one pseudo-monolayer coverage they did not impart sufficient hydrophobicity to the mineral to induce significant flotation recovery, with the recoveries ranging between 15 and 18%. Increasing the dosage of a strong collector such as PAX or the ionic strength of the process water used in the flotation was shown to improve the recovery of sperrylite to 45% at 20 monolayers of PAX and 20.6% at 0.12 M ionic strength. Batch flotation tests showed that the increases in sperrylite recovery achieved under different conditions were non-selective towards sperrylite and came at the expense of an increase in total solids recovered. This investigation has provided further insights into the possible reasons for the poor floatability of sperrylite which may guide future work on improving the recovery of this economically important mineral.

Facile "Synergistic Inner-Outer Activation" Strategy for Nano-Engineering of Nature-Skin-Derived Wearable Daytime Radiation Cooling Materials.

Natural skin-derived products, as traditional wearable materials are widely used in people's daily life due to the products' excellent origins. Herein, a versatile daytime-radiation cooling wearable natural skin (RC-skin) consisting of the collagen micro-nano fibers with the on-demand double-layer radiation cooling structure is nano-engineered through the proposed facile "synergistic inner-outer activation" strategy. The bottom layer (inner strategy) of the RC-skin is fabricated by filling the skin with the Mg11 (HPO3 )8 (OH)6 nanoparticles by soaking. The superstratum (outer strategy) is constituted by a composite coating with an irregular microporous structure. The RC-skin harvests the inherent advantages of natural building blocks including sufficient hydrophobicity, excellent mechanical properties, and friction resistance. Owing to the subtle double-layer structure design, the solar reflectance and the average emissivity in the mid-infrared band of RC-skin are ≈92.7% and ≈95%, respectively. Therefore, the RC-skin's temperature in the sub-ambient is reduced by ≈7.5°C. Various outdoor practical application experiments further substantiate that RC-skin has superior radiation cooling performances. Collectively, RC-skin has broad-application prospects for intelligent wearing, low-carbon travel, building materials, and intelligent thermoelectric power generation, and this study also provides novel strategies for developing natural-skin-derived functional materials.

Functionalization of Diamine-Appended MOF-Based Adsorbents by Ring Opening of Epoxide: Long-Term Stability and CO2 Recyclability under Humid Conditions.

Although diamine-appended metal-organic framework (MOF) adsorbents exhibit excellent CO2 adsorption performance, a continuous decrease in long-term capacity during repeated wet cycles remains a formidable challenge for practical applications. Herein, we present the fabrication of diamine-appended Mg2(dobpdc)-alumina beads (een-MOF/Al-Si-Cx; een = N-ethylethylenediamine; x = number of carbon atoms attached to epoxide) coated with hydrophobic silanes and alkyl epoxides. The reaction of epoxides with diamines in the portal of the pore afforded sufficient hydrophobicity, hindered the penetration of water vapor into the pores, and rendered the modified diamines less volatile. een-MOF/Al-Si-C17-200 (een-MOF/Al-Si-C17-y; y = 50, 100, and 200, denoting wt % of C17 with respect to the bead, respectively), with substantial hydrophobicity, showed a significant uptake of 2.82 mmol g-1 at 40 °C and 15% CO2, relevant to flue gas concentration, and a reduced water adsorption. The modified beads maintained a high CO2 capacity for over 100 temperature-swing adsorption cycles in the presence of 5% H2O and retained CO2 separation performance in breakthrough tests under humid conditions. This result demonstrates that the epoxide coating provides a facile and effective method for developing promising adsorbents with high CO2 adsorption capacity and long-term durability, which is a required property for postcombustion applications.

Transport features predict if a molecule is odorous

In studies of vision and audition, stimuli can be chosen to span the visible or audible spectrum; in olfaction, the axes and boundaries defining the analogous odorous space are unknown. As a result, the population of olfactory space is likewise unknown, and anecdotal estimates of 10,000 odorants have endured. The journey a molecule must take to reach olfactory receptors (ORs) and produce an odor percept suggests some chemical criteria for odorants: a molecule must 1) be volatile enough to enter the air phase, 2) be nonvolatile and hydrophilic enough to sorb into the mucous layer coating the olfactory epithelium, 3) be hydrophobic enough to enter an OR binding pocket, and 4) activate at least one OR. Here, we develop a simple and interpretable quantitative model that reliably predicts whether a molecule is odorous or odorless based solely on the first three criteria. Applying our model to a database of all possible small organic molecules, we estimate that at least 40 billion possible compounds are odorous, six orders of magnitude larger than current estimates of 10,000. With this model in hand, we can define the boundaries of olfactory space in terms of molecular volatility and hydrophobicity, enabling representative sampling of olfactory stimulus space.

Material Selection for the Hydrophobic Cushion Layer Applied to Earthen Sites in Northwest China

ABSTRACT Earthen sites with important historical, cultural, artistic, social, and scientific values have been seriously damaged. Basal erosion, which is caused by soluble salts, water runoff, and sand-driving wind, is an extremely threatening erosion pattern for earthen sites. A cushion layer which has a damp-proofing function and good physical and mechanical properties can effectively decrease basal erosion. The primary aim of this study is to investigate material selection for the hydrophobic cushion layer for earthen sites in northwest China. The results indicate that cooked tung oil and sticky rice liquid, traditionally used in China, cannot meet the fundamental requirements of sufficient hydrophobicity for the cushion layer. Although polyvinyl alcohol (PVA) solution and tung oil exhibit similar properties in terms of soil hydrophobicity, water vapour permeability, water resistance, surface hardness, and colour difference for samples with 0.0-1.0% content, the PVA solution is significantly better than tung oil in unconfined compressive strength, deformation modulus, wave velocity, and viscosity. Therefore, the PVA solution should be preferentially selected as a hydrophobic cushion layer material according to the results of this work. When the mixing method is adopted, 0.6-1.0% PVA content is the best choice.

Enhancement of Catalytic Activity and Selectivity for the Gaseous Electroreduction of CO2 to CO: Guidelines for the Selection of Carbon Supports

AbstractTo secure the economic feasibility of electrochemical carbon dioxide reduction reaction (CO2RR), a method of using support materials to reduce the amount of catalyst loading and increase catalytic activity for CO2RR can be a solution. Herein, guidelines for selecting carbon support materials suitable for CO2RR are reported. In a gaseous CO2‐fed CO2RR electrolyzer, an Ag nanoparticle‐composited carbon nanocage (denoted as Ag/CNC) electrode exhibits an optimal performance for CO2RR with a partial current density of ≈400 mA cm−2. Ag/CNC showcases a uniformly dispersed morphology with Ag nanoparticles and sufficient hydrophobicity after the reaction to prevent flooding, which is known to inhibit the mass transfer of CO2. Furthermore, the CNCs possess small amounts of carbon defects; this suppresses the catalytic activity for the hydrogen evolution reaction (HER), which is a side reaction of CO2RR. Results of a three‐stack cell experiment with the Ag/CNC electrode reveal the possibility of a support‐based strategy for achieving an industrial‐level scaling of CO2RR. This study suggests that the support material for CO2RR should be considered not only on the basis of the morphology of carbon, uniform dispersion of Ag nanoparticles, and hydrophobicity of the electrode but also factors influencing the HER, such as carbon defects.

Hierarchical Copper with Inherent Hydrophobicity Mitigates Electrode Flooding for High-Rate CO2 Electroreduction to Multicarbon Products.

Copper is currently the material with the most promise as catalyst to drive carbon dioxide (CO2) electroreduction to produce value-added multicarbon (C2+) compounds. However, a copper catalyst on a carbon-based gas diffusion layer electrode often has poor stability-especially when performing at high current densities-owing to electrolyte flooding caused by the hydrophobicity decrease of the gas diffusion layer during operation. Here, we report a bioinspired copper catalyst on a gas diffusion layer that mimics the unique hierarchical structuring of Setaria's hydrophobic leaves. This hierarchical copper structure endows the CO2 reduction electrode with sufficient hydrophobicity to build a robust gas-liquid-solid triple-phase boundary, which can not only trap more CO2 close to the active copper surface but also effectively resist electrolyte flooding even under high-rate operation. We consequently achieved a high C2+ production rate of 255 ± 5.7 mA cm-2 with a 64 ± 1.4% faradaic efficiency, as well as outstanding operational stability at 300 mA cm-2 over 45 h in a flow reactor, largely outperforming its wettable copper counterparts.

Effect of carbonization temperature on properties of natural fiber and charcoal filled hybrid polymer composite

In this study, bamboo fiber filled polypropylene composites (BPCs) were prepared using bamboo and coconut shell charcoal as reinforcing fillers for enhancing the properties of composites. Bamboo and coconut shell biomass were carbonized at different carbonization temperatures (300, 400, 600, and 900OC); 1 h soaking time and at 5OC−min heating rates. The effect of carbonization temperature and charcoal content (0.5%, 1.0% and 1.5%) on mechanical, thermal and water absorption properties of BPCs has been investigated. The experimental results show that charcoal which is obtained at lower pyrolysis temperature (300OC and 400OC) improves the strength properties of BPCs, whereas, strength properties remains unaltered when charcoal prepared at elevated temperatures (600OC and 900OC) are added to BPCs. Compared to coconut shell charcoal (CSC) better mechanical properties were obtained through bamboo charcoal (BC). This has been attributed to flakes like appearance of BC, having pores present on their surfaces. The study also shows that addition of charcoal provides thermal stability to BPCs, particularly via charcoal prepared at elevated temperature (900OC). The optimum temperature for achieving sufficient hydrophobicity in BPCs is found to be 300OC and 600OC for BC and CSC, respectively.

Evaluation of a novel and highly hydrophobic acrylonitrile-butadiene-styrene membrane for direct contact membrane distillation: Electroblowing/air-assisted electrospraying techniques

Novel nanofibrous membranes were fabricated from acrylonitrile-butadiene-styrene (ABS) polymer using electroblowing process. Air-assisted electrospraying was applied to produce highly hydrophobic surfaces. The ABS membranes were coated using a dope solution including 6 wt% polystyrene (PS) in dimethylformamide. The beaded structure mounted on the hot-pressed ABS support layer demonstrated extremely rough character with a hierarchical structure. The water contact angle was significantly enhanced from 137.9 to 157.8°. Moreover, the liquid entry pressure of water (LEP) of the fabricated ABS membranes was incredibly improved 4.1 times compared to the neat one. By using high saline (250 g/L) and low surface tension (up to 2 mM sodium dodecyl sulfate) feeds, the well-modified membrane showed excellent direct contact membrane distillation (DCMD) performance with stable permeate flux and salt rejection factor due to high LEP value and sufficient hydrophobicity. Combining low-cost ABS and PS polymers with the productive electroblowing/air-assisted electrospraying process can pave the way for fabricating more robust membrane distillation (MD) membranes with anti-scaling/wetting properties.

C-terminal tail length guides insertion and assembly of membrane proteins

A large number of newly synthesized membrane proteins in the endoplasmic reticulum (ER) are assembled into multiprotein complexes, but little is known about the mechanisms required for assembly membrane proteins. It has been suggested that membrane chaperones might exist, akin to the molecular chaperones that stabilize and direct the assembly of soluble protein complexes, but the mechanisms by which these proteins would bring together membrane protein components is unclear. Here, we have identified that the tail length of the C-terminal transmembrane domains (C-TMDs) determines efficient insertion and assembly of membrane proteins in the ER. We found that membrane proteins with C-TMD tails shorter than ∼60 amino acids are poorly inserted into the ER membrane, which suggests that translation is terminated before they are recognized by the Sec61 translocon for insertion. These C-TMDs with insufficient hydrophobicity are post-translationally recognized and retained by the Sec61 translocon complex, providing a time window for efficient assembly with TMDs from partner proteins. Retained TMDs that fail to assemble with their cognate TMDs are slowly translocated into the ER lumen and are recognized by the ER-associated degradation (ERAD) pathway for removal. In contrast, C-TMDs with sufficient hydrophobicity or tails longer than ∼80 residues are quickly released from the Sec61 translocon into the membrane or the ER lumen, resulting in inefficient assembly with partner TMDs. Thus, our data suggest that C-terminal tails harbor crucial signals for both the insertion and assembly of membrane proteins.

Evaluation of thermally hydrolyzed specified risk materials cross-linked with glutaraldehyde for tackifier applications

Specified risk materials (SRMs) are the tissues in cattle where misfolded proteins that cause "mad cow disease" are likely to concentrate, and thus they must be segregated from normal consumption. In this study, peptides derived from SRM hydrolysates were characterized and applied in the development of tackifiers. As one of the key components of a hydro-mulch mixture, tackifiers are employed to bind wood fibres and seeds of plants to the soil in order to facilitate improved rooting. However, sufficient hydrophobicity is also required by tackifiers to prevent diffusion and loss of function when exposed to high levels of moisture. Thus, glutaraldehyde cross-linking was examined to moderate hydrophobicity of SRM-derived peptides. Moreover, other characteristics of the peptides and cross-linked products were assessed and compared with commercial tackifiers. This demonstrated the competitiveness and potential of our SRM bioconversion strategy to produce tackifiers.

Distinct Requirements for Tail-Anchored Membrane Protein Biogenesis in Escherichia coli.

Tail-anchored membrane proteins (TAMPs) are a distinct subset of inner membrane proteins (IMPs) characterized by a single C-terminal transmembrane domain (TMD) that is responsible for both targeting and anchoring. Little is known about the routing of TAMPs in bacteria. Here, we have investigated the role of TMD hydrophobicity in tail-anchor function in Escherichia coli and its influence on the choice of targeting/insertion pathway. We created a set of synthetic, fluorescent TAMPs that vary in the hydrophobicity of their TMDs and corresponding control polypeptides that are extended at their C terminus to create regular type II IMPs. Surprisingly, we observed that TAMPs have a much lower TMD hydrophobicity threshold for efficient targeting and membrane insertion than their type II counterparts. Using strains conditional for the expression of known membrane-targeting and insertion factors, we show that TAMPs with strongly hydrophobic TMDs require the signal recognition particle (SRP) for targeting. Neither the SecYEG translocon nor YidC appears to be essential for the membrane insertion of any of the TAMPs studied. In contrast, corresponding type II IMPs with a TMD of sufficient hydrophobicity to promote membrane insertion followed an SRP- and SecYEG translocon-dependent pathway. Together, these data indicate that the capacity of a TMD to promote the biogenesis of E. coli IMPs is strongly dependent upon the polypeptide context in which it is presented.IMPORTANCE A subset of membrane proteins is targeted to and inserted into the membrane via a hydrophobic transmembrane domain (TMD) that is positioned at the very C terminus of the protein. The biogenesis of these so-called tail-anchored proteins (TAMPs) has been studied in detail in eukaryotic cells. Various partly redundant pathways were identified, the choice for which depends in part on the hydrophobicity of the TMD. Much less is known about bacterial TAMPs. The significance of our research is in identifying the role of TMD hydrophobicity in the routing of E. coli TAMPs. Our data suggest that both the nature of the TMD and its role in routing can be very different for TAMPs versus "regular" membrane proteins. Elucidating these position-specific effects of TMDs will increase our understanding of how prokaryotic cells face the challenge of producing a wide variety of membrane proteins.

Metal-Organic Frameworks for Cultural Heritage Preservation: The Case of Acetic Acid Removal.

The removal of low concentrations of acetic acid from indoor air at museums poses serious preservation problems that the current adsorbents cannot easily address owing to their poor affinity for acetic acid and/or their low adsorption selectivity versus water. In this context, a series of topical water-stable metal-organic frameworks (MOFs) with different pore sizes, topologies, hydrophobic characters, and functional groups was explored through a joint experimental-computational exploration. We demonstrate how a subtle combination of sufficient hydrophobicity and optimized host-guest interactions allows one to overcome the challenge of capturing traces of this very polar volatile organic compound in the presence of humidity. The optimal capture of acetic acid was accomplished with MOFs that do not show polar groups in the inorganic node or have lipophilic but polar (e.g., perfluoro) groups functionalized to the organic linkers, that is, the best candidates from the list of explored MOFs are MIL-140B and UiO-66-2CF3. These two MOFs present the appropriate pore size to favor a high degree of confinement, together with organic spacers that allow an enhancement of the van der Waals interactions with the acetic acid. We establish in this work that MOFs can be a viable solution to this highly challenging problem in cultural heritage protection, which is a new field of application for this type of hybrid materials.