Sucralose Control Research Articles

Pre-meal active video game playing increased subjective appetite but not food intake in children and adolescents

ObjectiveSedentary video game playing (VGP) and caloric preloads in the pre-meal environment have been shown to influence short-term food intake (FI) regulation in children. Other factors that may affect FI control include physical activity and/or heightened emotion. Therefore, we examined the effects of a glucose preload and 30 min of active VGP (aVGP) on subjective appetite, short-term FI, and subjective emotions in 9-14 year-old children. MethodsOn four test mornings approximately one-week apart, twenty-seven children (sex: 15M, 12F; age: 11.3 ± 0.3 years; BMI percentile: 55.3 ± 6.1%) consumed a standardized breakfast two hours prior to consuming 250 mL of either a 50 g glucose preload or Sucralose® control. Following the preload, participants participated in 30 min of quiet sitting or aVGP. Energy expenditure was measured during aVGP via indirect calorimetry. FI from an ad libitum pizza meal was measured after each test condition. Subjective appetite and emotions were measured at baseline (0 min), during treatment (15min), and immediately before the test meal (30 min). ResultsaVGP did not affect FI, but the glucose preload decreased FI compared with the sucralose control (∆ = 157 kcal, <0.001). Although not statistically significant (p=0.12), caloric compensation was lower following the glucose preload in the aVGP condition. Subjective appetite increased with time, and was higher in the sucralose control + aVGP condition (p=0.05). Change from baseline subjective emotion scores of anger and excitement were higher (p=0.03) and lower (p=0.02) after aVGP, respectively. ConclusionsNeither short-term FI nor net energy balance were affected by low-intensity aVGP (energy expenditure of 34 kcal). These findings suggest that a short bout of low-intensity aVGP does not alter energy balance during the study measurement period, and may not support achieving or maintaining healthy weights in children. However, future longitudinal studies are needed to confirm such advice.

Effect of video game playing and a glucose preload on subjective appetite, subjective emotions, and food intake in overweight and obese boys.

Video game playing (VGP) is associated with overweight/obesity (OW/OB). VGP and caloric preloads in the pre-meal environment influence short-term food intake (FI) in healthy-weight children. Therefore, the purpose of the present study was to examine the effect of pre-meal VGP and a glucose preload on subjective emotions, subjective appetite, and FI in boys with OW/OB. On 4 separate mornings, boys with OW/OB (n = 22; mean ± SD: age = 11.9 ± 1.6 years; body mass index percentile = 94.3 ± 3.9) participated in 4 test conditions. Two hours after a standardized breakfast, boys consumed equally sweetened preloads (250 mL) of sucralose (0 kcal) or glucose (200 kcal), with or without 30 min of subsequent VGP. Immediately after each test condition, FI was evaluated during an ad libitum pizza meal. Subjective appetite was measured at 0 (baseline), 15, and 30 min. Subjective emotions (aggression, anger, excitement, disappointment, happiness, upset, and frustration) were measured at 0 and 30 min. VGP did not affect FI, but the glucose preload decreased FI compared with the sucralose control (Δ = -103 ± 48 kcal, p < 0.01). However, cumulative FI (preload kcal + meal kcal) was 9% higher after the glucose preload (p < 0.01). Subjective appetite increased with time (p < 0.05) but was not influenced by preload or VGP. Frustration was the only subjective emotion that increased following VGP (p < 0.01). A glucose preload, but not VGP, suppressed FI in boys with OW/OB, suggesting a primary role of physiological factors in short-term FI regulation.

Effect of Sugars in Solutions on Immediate and Delayed Word List Recall in Normal Weight Boys

Background: Dietary glucose improves memory performance in several adult populations; however, there are no comparative studies of commonly consumed sugars on memory performance in children. Objectives: The objective was to compare the effect of glucose, sucrose and high-fructose corn syrup-55 (HFCS) solutions on immediate and delayed word list recall in 9 to 14 year-old normal weight boys. Patients and Methods: In a repeated measures design, 15 normal weight boys received, in random order, preloads (200 kcal/250 mL) of glucose, sucrose, HFCS, or non-caloric sucralose control. The boys were presented with a 15 item word list to memorize 15 minutes after ingestion of the preloads and asked to recall the words immediately after, and at 30, 45, 60 and 90 minutes. Results: There were no significant differences among the glucose, sucrose and HFCS preloads on word list recall compared with the noncaloric sucralose control at any of the time points. However, word list recall was highest at 15 minutes, and decreased over time to 90 minutes after all preloads (P < 0.0001). Conclusions: Sugars in solutions do not differ in their effects on word list memory recall compared with a non-caloric sucralose control in 9 to 14 year-old normal weight boys.

Pre-meal video game playing and a glucose preload suppress food intake in normal weight boys

Increased food intake (FI) during television viewing has been reported in children, but it is unknown if this occurs following pre-meal video game playing (VGP). The objective was to determine the effect of pre-meal VGP for 30 min on subjective appetite and emotions, and FI in normal weight (NW) boys after a glucose or control preload. On four test mornings, NW boys (n = 19) received equally sweetened preloads of a non-caloric sucralose control or 50 g glucose in 250 mL of water, with or without VGP for 30 min. Food intake from an ad libitum pizza meal was measured immediately after. Subjective appetite was measured at 0, 15, 30, and 60 min. Subjective emotions were determined by visual analog scale at baseline and immediately before lunch. Both VGP (p = 0.023) and glucose (p < 0.001) suppressed FI. Pre-meal VGP compared with no-VGP, and glucose compared with the non-caloric control, decreased FI by 59 and 170 kcal, respectively. Subjective average appetite increased to 30 min (p = 0.003), but was lower after glucose (p = 0.01) in both the VGP and no-VGP conditions compared with the control. Frustration and aggression scores increased after VGP (p < 0.05), but did not correlate with FI. However, baseline and pre-meal happiness and excitement scores were inversely associated with FI. In conclusion, both pre-meal VGP and the glucose preload suppressed FI, supporting the roles of both physiologic and environmental factors in the regulation of short-term FI in 9- to 14-year-old NW boys.

A pre‐meal glucose drink, but not video game playing, suppresses food intake in overweight and obese boys (1040.8)

We previously reported decreased food intake (FI) after a glucose drink and 30 min of video game playing (VGP) in normal weight boys, but the effect on FI in boys with increased adiposity is unknown. Therefore, we examined the effect of 30 min of pre‐meal VGP on subjective appetite, emotions and FI in overweight/obese (&gt;85th BMI percentile) boys after a glucose drink. On four mornings, in random order and one‐week apart, boys (n = 22; age = 11.9 ± 0.3 y) consumed equally sweetened drinks (250 mL) of sucralose (0 kcal) or 50 g (200 kcal) glucose, with or without 30 min of subsequent VGP, 2 h after a standardized breakfast. Immediately after all test conditions FI (mean ± SEM kcal) from an ad libitum pizza meal was measured. Subjective appetite was measured at baseline (0 min), 20, 35, and 65 min (post‐meal). While glucose (p &lt; 0.01) decreased FI (∆ = ‐103 ± 48 kcal) compared with the sucralose control, cumulative FI (drink kcal + meal kcal) was higher (p &lt; 0.01). Fullness (p &lt; 0.05) was lower, and subjective aggressiveness (p &lt; 0.01), excitement (p &lt; 0.01), upset (p = 0.05), and frustration (p &lt; 0.05) higher after VGP; however, subjective emotions did not correlate with FI. In conclusion, the stronger effect of glucose compared with VGP on FI is indicative of the primary role of physiologic factors in the short‐term regulation of FI in overweight/obese boys.Grant Funding Source: Supported by The Danone Institute of Canada, Grant‐in‐aid program

Effect of sugars in solutions on subjective appetite and short-term food intake in 9- to 14-year-old normal weight boys

The role of sugars in solutions on subjective appetite and food intake (FI) has received little investigation in children. Therefore, we examined the effect of isocaloric solutions (200 kcal/250 ml) of sugars including sucrose, high-fructose corn syrup-55 (HFCS) or glucose, compared with a non-caloric sucralose control, on subjective appetite and FI in 9- to 14-year-old normal weight (NW) boys. NW boys (n=15) received each of the test solutions, in random order, 60 min before an ad libitum pizza meal. Subjective appetite was measured at baseline (0 min), and 15, 30, 45 and 60 min. Only glucose (P=0.003), but neither sucrose nor HFCS, reduced FI compared with the sucralose control. This led to a higher cumulative energy intake, compared with sucralose, after sucrose (P=0.009) and HFCS (P=0.01), but not after glucose. In all treatment sessions, subjective average appetite increased from baseline to 60 min, but change from baseline average appetite was the highest after sucrose (P<0.005). Furthermore, sucrose (r=-0.59, P=0.02) and HFCS (r=-0.56, P=0.03), but not glucose, were inversely associated with test meal FI when the treatment dose (200 kcal) was expressed on a body weight (kg) basis. Change from baseline subjective average appetite was the highest after sucrose, but only the glucose solution suppressed FI at the test meal 60 min later in NW boys.

Glucose utilization rates regulate intake levels of artificial sweeteners

It is well established that animals including humans attribute greater reinforcing value to glucose-containing sugars compared to their non-caloric counterparts, generally termed 'artificial sweeteners'. However, much remains to be determined regarding the physiological signals and brain systems mediating the attribution of greater reinforcing value to sweet solutions that contain glucose. Here we show that disruption of glucose utilization in mice produces an enduring inhibitory effect on artificial sweetener intake, an effect that did not depend on sweetness perception or aversion. Indeed, such an effect was not observed in mice presented with a less palatable, yet caloric, glucose solution. Consistently, hungry mice shifted their preferences away from artificial sweeteners and in favour of glucose after experiencing glucose in a hungry state. Glucose intake was found to produce significantly greater levels of dopamine efflux compared to artificial sweetener in dorsal striatum, whereas disrupting glucose oxidation suppressed dorsal striatum dopamine efflux. Conversely, inhibiting striatal dopamine receptor signalling during glucose intake in sweet-naïve animals resulted in reduced, artificial sweetener-like intake of glucose during subsequent gluco-deprivation. Our results demonstrate that glucose oxidation controls intake levels of sweet tastants by modulating extracellular dopamine levels in dorsal striatum, and suggest that glucose utilization is one critical physiological signal involved in the control of goal-directed sweetener intake.

The effect of sugars in solution on subjective appetite and short‐term food intake in normal weight boys

The role of sugars in solution in regulating appetite and food intake (FI) has received little investigation in children. Therefore, we examined the effect of sugars solutions (200 kcal) containing glucose, high‐fructose corn syrup‐55 (HFCS‐55), and sucrose on appetite and FI compared to a sucralose control in 9–14 y old normal weight (NW) boys. NW boys (n=15) received in random order four equally sweetened solutions containing sucralose (0 kcal), glucose, HFCS‐55 or sucrose made up to 250 mL with water 2 h after a standardized breakfast. FI (mean kcal ± SEM) at an ad libitum pizza meal was measured 60 min later. Subjective appetite was measured at baseline and at 15, 30, 45, 60 and 90 min. Compared to sucralose (1127 ± 56), glucose reduced FI by 18% (975 ± 58; P &lt; 0.01), however, HFCS‐55 (1075 ± 65) and sucrose (1074 ± 81) failed to result in a statistically significant decrease in FI. Caloric compensation scores for glucose, HFCS‐55 and sucrose were 76%, 26% and 26% respectively. Fat‐mass correlated positively with FI (r = 0.75, P &lt; 0.01). Change from baseline average appetite was higher after sucrose compared to all other treatments (P &lt; 0.01). We conclude that glucose, when compared to the other sugars solutions, produces greater physiological effects on FI in NW boys. Grant Funding Source: MSVU New Investigator Award.Grant Funding Source: MSVU New Investigator Award

Effect of short-duration physical activity and ventilation threshold on subjective appetite and short-term energy intake in boys

The purpose of this investigation was twofold: (1) to examine the role of low- to moderate-intensity, short-duration physical activity on subjective appetite and (2) to identify the role of and associations between ventilation threshold (VeT) and energy intake at a pizza lunch 30 min after glucose and whey protein drinks in normal weight boys. In 14 boys (age: 12.5±0.4 years) subjective appetite was measured before and after a 12 min walking protocol designed to determine physical fitness based on the VeT. On a separate occasion food intake (FI) and subjective appetite were measured in response to sweetened preloads of either a SPLENDA ® Sucralose control, glucose or whey protein made up to 250 ml with water, given in random order to each boy, 2 h after a standardized breakfast. Subjective average appetite and prospective food consumption scores increased after physical activity. VeT was positively associated with FI at a pizza lunch consumed 30 min after glucose and whey protein drinks. Glucose and whey protein reduced FI similarly at lunch compared with control. In conclusion, appetite is increased by low- to moderate-intensity, short-duration physical activity and FI following glucose and protein preloads is positively associated with fitness levels in boys.