•Employ key strategies to write a compelling introduction that makes the case for a manuscript's importance.•Craft a manuscript that anticipates common concerns of editors and reviewers.•Employ key strategies to maximize the readability and appeal of interdisciplinary journal articles. Writing a journal manuscript for a single audience is relatively straightforward. Physicians, nurses, and social workers (for instance) have specific implicit and explicit expectations for an article's style and content. Those expectations are expressed and interpreted through the comments of a journal's reviewers, and the decision of its editor. When authors seek to write manuscripts that cross professional, research, and practice boundaries, addressing the audience becomes much more complex. How do you meet the expectations of a diverse set of reviewers, and an editor who may not be familiar with the customs and issues of another discipline? How do you satisfy researchers who expect in-depth methods descriptions but also clinicians who want to understand a study's clinical importance? How do you develop implications for practice and policy that address important cross-cutting issues for an interdisciplinary audience? How do you give voice to your disciplinary perspective in a manner that can be heard by others with a different view? In this session, three experienced researchers assume the roles of author, reviewer and journal editor. We share our tips for writing successful manuscripts that cross disciplinary boundaries and settings, and which will appeal to a diverse population of reviewers, editors, and readers. We describe key elements of a manuscript, including the abstract, introduction, methods and results, and discuss how to make them accessible to a diverse audience. We pay special attention to “non-traditional” manuscripts that describe the results of reviews, meta-analyses, and quality improvement projects. We address translational issues specifically focusing on how research informs practice and ways to communicate that to readers from various disciplines. Participants will gain concrete, usable skills for writing an interdisciplinary manuscript.