Successful Episodic Memory Encoding Research Articles

Does data cleaning improve brain state classification?

BackgroundNeuroscientists routinely seek to identify and remove noisy or artifactual observations from their data. They do so with the belief that removing such data improves power to detect relations between neural activity and behavior, which are often subtle and can be overwhelmed by noise. Whereas standard methods can exclude certain well-defined noise sources (e.g., 50/60 Hz electrical noise), in many situations there is not a clear difference between noise and signals so it is not obvious how to separate the two. Here we ask whether methods routinely used to “clean” human electrophysiological recordings lead to greater power to detect brain–behavior relations. New methodThis, to the authors’ knowledge, is the first large-scale simultaneous evaluation of multiple commonly used methods for removing noise from intracranial EEG recordings. ResultsWe find that several commonly used data cleaning methods (automated methods based on statistical signal properties and manual methods based on expert review) do not increase the power to detect univariate and multivariate electrophysiological biomarkers of successful episodic memory encoding, a well-characterized broadband pattern of neural activity observed across the brain. Comparison with existing methodsResearchers may be more likely to increase statistical power to detect physiological phenomena of interest by allocating resources away from cleaning noisy data and toward collecting more within-patient observations. ConclusionsThese findings highlight the challenge of partitioning signal and noise in the analysis of brain-behavior relations, and suggest increasing sample size and numbers of observations, rather than data cleaning, as the best approach to improving statistical power.

Elaboration Benefits Source Memory Encoding Through Centrality Change

Variations in levels of processing affect memory encoding and subsequent retrieval performance, but it is unknown how processing depth affects communication patterns within the network of interconnected brain regions involved in episodic memory encoding. In 113 healthy adults scanned with functional MRI, we used graph theory to calculate centrality indices representing the brain regions’ relative importance in the memory network. We tested how communication patterns in 42 brain regions involved in episodic memory encoding changed as a function of processing depth, and how these changes were related to episodic memory ability. Centrality changes in right middle frontal gyrus, right inferior parietal lobule and left superior frontal gyrus were positively related to semantic elaboration during encoding. In the same regions, centrality during successful episodic memory encoding was related to performance on the episodic memory task, indicating that these centrality changes reflect processes that support memory encoding through deep elaborative processing. Similar analyses were performed for congruent trials, i.e. events that fit into existing knowledge structures, but no relationship between centrality changes and congruity were found. The results demonstrate that while elaboration and congruity have similar beneficial effects on source memory performance, the cortical signatures of these processes are probably not identical.

The effect of hippocampal function, volume and connectivity on posterior cingulate cortex functioning during episodic memory fMRI in mild cognitive impairment

ObjectivesDiminished function of the posterior cingulate cortex (PCC) is a typical finding in early Alzheimer’s disease (AD). It is hypothesized that in early stage AD, PCC functioning relates to or reflects hippocampal dysfunction or atrophy. The aim of this study was to examine the relationship between hippocampus function, volume and structural connectivity, and PCC activation during an episodic memory task-related fMRI study in mild cognitive impairment (MCI).MethodMCI patients (n = 27) underwent episodic memory task-related fMRI, 3D-T1w MRI, 2D T2-FLAIR MRI and diffusion tensor imaging. Stepwise linear regression analysis was performed to examine the relationship between PCC activation and hippocampal activation, hippocampal volume and diffusion measures within the cingulum along the hippocampus.ResultsWe found a significant relationship between PCC and hippocampus activation during successful episodic memory encoding and correct recognition in MCI patients. We found no relationship between the PCC and structural hippocampal predictors.ConclusionsOur results indicate a relationship between PCC and hippocampus activation during episodic memory engagement in MCI. This may suggest that during episodic memory, functional network deterioration is the most important predictor of PCC functioning in MCI.Key Points• PCC functioning during episodic memory relates to hippocampal functioning in MCI.• PCC functioning during episodic memory does not relate to hippocampal structure in MCI.• Functional network changes are an important predictor of PCC functioning in MCI.

Complementary Role of Frontoparietal Activity and Cortical Pattern Similarity in Successful Episodic Memory Encoding

One central goal in cognitive neuroscience of learning and memory is to characterize the neural processes that lead to long-lasting episodic memory. In addition to the stronger frontoparietal activity, greater category- or item-specific cortical representation during encoding, as measured by pattern similarity (PS), is also associated with better subsequent episodic memory. Nevertheless, it is unknown whether frontoparietal activity and cortical PS reflect distinct mechanisms. To address this issue, we reanalyzed previous data (Xue G, Dong Q, Chen C, Lu ZL, Mumford JA, Poldrack RA. 2010. Greater neural pattern similarity across repetitions is associated with better memory. Science. 330:97, Experiment 3) using a novel approach based on combined activation-based and information-based analyses. The results showed that across items, stronger frontoparietal activity was associated with greater PS in distributed brain regions, including those where the PS was predictive of better subsequent memory. Nevertheless, the item-specific PS was still associated with later episodic memory after controlling the effect of frontoparietal activity. Our results suggest that one possible mechanism of frontoparietal activity on episodic memory encoding is via enhancing PS, resulting in more unique and consistent input to the medial temporal lobe. In addition, they suggest that PS might index additional processes, such as pattern reinstatement as a result of study-phase retrieval, that contribute to episodic memory encoding.

Glucose administration enhances fMRI brain activation and connectivity related to episodic memory encoding for neutral and emotional stimuli

Glucose enhances memory in a variety of species. In humans, glucose administration enhances episodic memory encoding, although little is known regarding the neural mechanisms underlying these effects. Here we examined whether elevating blood glucose would enhance functional MRI (fMRI) activation and connectivity in brain regions associated with episodic memory encoding and whether these effects would differ depending on the emotional valence of the material. We used a double-blind, within-participants, crossover design in which either glucose (50g) or a saccharin placebo were administered before scanning, on days approximately 1 week apart. We scanned healthy young male participants with fMRI as they viewed emotionally arousing negative pictures and emotionally neutral pictures, intermixed with baseline fixation. Free recall was tested at 5min after scanning and again after 1 day. Glucose administration increased activation in brain regions associated with successful episodic memory encoding. Glucose also enhanced activation in regions whose activity was correlated with subsequent successful recall, including the hippocampus, prefrontal cortex, and other regions, and these effects differed for negative vs. neutral stimuli. Finally, glucose substantially increased functional connectivity between the hippocampus and amygdala and a network of regions previously implicated in successful episodic memory encoding. These findings fit with evidence from nonhuman animals indicating glucose modulates memory by selectively enhancing neural activity in brain regions engaged during memory tasks. Our results highlight the modulatory effects of glucose and the importance of examining both regional changes in activity and functional connectivity to fully characterize the effects of glucose on brain function and memory.

FMRI Activation Changes during Successful Episodic Memory Encoding and Recognition in Amnestic Mild Cognitive Impairment Relative to Cognitively Healthy Older Adults

Background/Aims: Previous functional MRI studies in individuals with amnestic mild cognitive impairment (AMCI), a putative, prodromal form of Alzheimer’s disease, reveal substantial regional changes in brain activation during episodic memory function. Methods: Functional MRI was applied to examine changes in brain activation during different stages of episodic memory function using a subsequent memory task in individuals with AMCI relative to older normal controls. Results: We found that the AMCI group displayed greater activation in the right hippocampus but less activation in the frontal cortex relative to the older normal control group during intentional encoding of items that were subsequently recognized. We observed nearly the opposite pattern of results for successful recognition. The AMCI group displayed less activation in the medial temporal cortex but greater activation in the frontal cortex. In addition, the AMCI group showed reduced activation in the medial temporal and frontal cortices during incidental encoding of novel information during recognition. Conclusion: The results of the present study suggest that brain activation differences in individuals with AMCI are modulated by the stage of episodic memory examined (i.e. intentional vs. incidental encoding vs. recognition). These observations may help to clarify some of the conflicting findings regarding brain activation changes in AMCI.

IC-P1-062: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults

IC-P1-062: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults

P1-301: fMRI activation changes during successful episodic memory encoding and recognition in amnestic mild cognitive impairment relative to cognitively healthy older adults

Episodic memory dysfunction which is thought to be caused by neurodegenerative changes to the medial temporal lobes (MTL) is one of the earliest features of Alzhiemer's disease (AD). Recent evidence from metabolic and amyloid imaging studies also reveal early pathophysiological changes in the posterior cingulate cortex (PCC) and frontal cortex (FC). Previous functional MRI (fMRI) studies of episodic memory function in individuals with amnestic-mild cognitive impairment (AMCI), a prodromal form of AD, have revealed have failed to reveal a consistent pattern of fMRI activation changes (i.e., increases or decreases) in these same brain regions. In the present study, we used fMRI to examine changes in brain activation in individual with AMCI relative to older normal controls (ONC) during successful episodic encoding and recognition using a well-studied, subsequent memory paradigm. We found that the individuals with AMCI displayed reduced activation relative to an older normal control (ONC) group in the left hippocampus and bilaterally in the medial prefrontal and posterior cingulate cortices during episodic recognition. In contrast, individuals with AMCI were found to display greater activation in the right hippocampus relative to the ONC group during the encoding of items that were subsequently recognized accurately. The results of the present study suggest that brain activation differences in individuals with AMCI are modulated by the stage of episodic memory examined (i.e., encoding versus recognition). These findings may help to clarify some of the conflicting findings regarding brain activation changes in AMCI.

Effects of study task on the neural correlates of source encoding.

The present study investigated whether the neural correlates of source memory vary according to study task. Subjects studied visually presented words in one of two background contexts. In each test, subjects made old/new recognition and source memory judgments. In one study test cycle, study words were subjected to animacy judgments, whereas in another cycle the study task required syllable judgments. Functional magnetic resonance imaging (fMRI) was employed to contrast the neural activity elicited by study words that attracted accurate source judgments on the later memory test, as opposed to words for which source judgments were incorrect or for which source information was unavailable. In both tasks, relative to words for which source memory failed, study words that were later assigned to the correct source elicited enhanced activity in ventral extrastriate cortex. In addition to these common effects of subsequent source memory, additional effects were observed that were selective for each study task. The present findings add weight to the proposal that neural activity supporting successful episodic memory encoding is a reflection of both the online processing engaged by an episode as it is experienced, and the demands imposed by the later retrieval task.

The effect of scene context on episodic object recognition: Parahippocampal cortex mediates memory encoding and retrieval success

Previous research has investigated intentional retrieval of contextual information and contextual influences on object identification and word recognition, yet few studies have investigated context effects in episodic memory for objects. To address this issue, unique objects embedded in a visually rich scene or on a white background were presented to participants. At test, objects were presented either in the original scene or on a white background. A series of behavioral studies with young adults demonstrated a context shift decrement (CSD)-decreased recognition performance when context is changed between encoding and retrieval. The CSD was not attenuated by encoding or retrieval manipulations, suggesting that binding of object and context may be automatic. A final experiment explored the neural correlates of the CSD, using functional Magnetic Resonance Imaging. Parahippocampal cortex (PHC) activation (right greater than left) during incidental encoding was associated with subsequent memory of objects in the context shift condition. Greater activity in right PHC was also observed during successful recognition of objects previously presented in a scene. Finally, a subset of regions activated during scene encoding, such as bilateral PHC, was reactivated when the object was presented on a white background at retrieval. Although participants were not required to intentionally retrieve contextual information, the results suggest that PHC may reinstate visual context to mediate successful episodic memory retrieval. The CSD is attributed to automatic and obligatory binding of object and context. The results suggest that PHC is important not only for processing of scene information, but also plays a role in successful episodic memory encoding and retrieval. These findings are consistent with the view that spatial information is stored in the hippocampal complex, one of the central tenets of Multiple Trace Theory.

Distinguishing the Neural Correlates of Episodic Memory Encoding and Semantic Memory Retrieval

Episodic memory and semantic memory interact very closely. In particular, episodic memory encoding (EE) tends to elicit semantic memory retrieval (SR), and vice versa. Thus, similar activations for EE and SR in functional neuroimaging studies may reflect shared memory processes, or they may reflect the fact that EE and SR are usually confounded. To address this issue, we used a factorial functional magnetic resonance imaging approach to disentangle the neural correlates of EE and SR. Within the left temporal lobe, the hippocampus was associated with successful EE, whereas a posterior lateral region was associated with successful SR. Within the left inferior prefrontal cortex, a posterior region was involved in SR, a mid region was involved in both SR and EE, and an anterior region was involved in EE, but only when SR was also high. Thus, the neural correlates of EE and SR are dissociable but interact in specific brain regions.

Dissociable Human Perirhinal, Hippocampal, and Parahippocampal Roles during Verbal Encoding

The precise contribution of perirhinal cortex to human episodic memory is uncertain. Human intracranial recordings highlight a role in successful episodic memory encoding, but encoding-related perirhinal activation has not been observed with functional imaging. By adapting functional magnetic resonance imaging scanning parameters to maximize sensitivity to medial temporal lobe activity, we demonstrate that left perirhinal and hippocampal responses during word list encoding are greater for subsequently recalled than forgotten words. Although perirhinal responses predict memory for all words, successful encoding of initial words in a list, demonstrating a primacy effect, is associated with parahippocampal and anterior hippocampal activation. We conclude that perirhinal cortex and hippocampus participate in successful memory encoding. Encoding-related parahippocampal and anterior hippocampal responses for initial, remembered words most likely reflects enhanced attentional orienting to these positionally distinctive items.