The development of subway and highway tunnels has led to the spatial intersection of tunnels, significantly impacting tunnel deformation, lining stress, and ground settlement during construction. To study the influence of critical parameters such as the cross angle and centre-to-centre distance on the tunnel performance, a series of numerical simulations were carried out. The influence range and magnitude of stress in the spatial cross tunnel under different cross angles were determined. The results indicated that as the crossing angle increased, the stress on the lining decreased, and the vault displacement increased. Meanwhile, the parallel tunnels showed opposite tendencies. Based on these results, the crossing angle of the cross tunnels was suggested to be greater than 45°. Parallel tunnels should be considered individually because the loading is symmetrically distributed. Considering the vault displacement and von Mises stress of the lining, it is recommended that the tunnel spacing be greater than 2D. The numerical model was validated against field data, and the findings of this study can be useful in designing cross tunnels.