Event Abstract Back to Event Influence of Electrical Stimulation of Substantia Nigra on the Neuronal Activity of Central Gray Matter during Tail Flick Reflex Elene Abzianidze1*, Tinatin Tkemaladze1, Viola Berishvili1, Gulnazi Gurtskaia2 and Merab Tsagareli2 1 Tbilisi State Medical University, Georgia 2 I. Beritashvili Institute of Physiology, Georgia Aim of Investigation: Influence of electrical stimulation of substantia nigra on the neuronal activity of Central Gray Matter during tail flick reflex was investigating in albino rats. Methods: As a model of pain we used tail stimulation with focused infrared light. An opioid analgesic (morphine, 0.5-4 mg/kg) and an agonist (parlodel, 0.05-0.1 mg/kg) and antagonist (alkopride, 0.1-1.2 mg/kg) of dopaminergic receptors were used for neuropharmacological analysis. Results:In chronic experiments on albino rats it was shown that electrical stimulation of substantia nigra induces activation of the “off”neurons and inhibition of “on” neurons of the Central Gray Matter (CGM); the latency of the tail-flick reflex was increased as well. After injection of alkopride, the antagonist of dopaminergic receptor, the antinocicptive effect induced by stimulation of substantia nigra decreased. Injection of parlodel (0.05-1 mg/kg), as well as morphine (2-4 mg/kg) increases latent period of nociceptive reflex dose-dependently. Subthreshold electrical stimulation of substantia nigra against a background of subanalgetic dose of morphine (0.5-1 mg/kg) induced potentiation of morphine’s effect. Conclusions:Antinociceptive effect of substantia nigra on nociceptive afferentation accomplished with interaction of opiate and dopaminergic systems. Acknowledgements: This study was supported by: Tbilisi State Medical University & Georgian National Science Foundation (GNSF/ST07/6-234). Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Abzianidze E, Tkemaladze T, Berishvili V, Gurtskaia G and Tsagareli M (2009). Influence of Electrical Stimulation of Substantia Nigra on the Neuronal Activity of Central Gray Matter during Tail Flick Reflex. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.065 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 05 Jun 2009; Published Online: 05 Jun 2009. * Correspondence: Elene Abzianidze, Tbilisi State Medical University, Tbilisi, Georgia, eabzianidze@tsmu.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Elene Abzianidze Tinatin Tkemaladze Viola Berishvili Gulnazi Gurtskaia Merab Tsagareli Google Elene Abzianidze Tinatin Tkemaladze Viola Berishvili Gulnazi Gurtskaia Merab Tsagareli Google Scholar Elene Abzianidze Tinatin Tkemaladze Viola Berishvili Gulnazi Gurtskaia Merab Tsagareli PubMed Elene Abzianidze Tinatin Tkemaladze Viola Berishvili Gulnazi Gurtskaia Merab Tsagareli Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.