ABSTRACT Aim The aim of this study is to determine how CBT-based psychoeducation affects substance abuse proclivity in adolescent smokers. Materials and Methods The study is an experimental study model with pretest–posttest control group. As a result of the power analysis carried out for the sample of the study, the sample size was calculated to be 110 adolescent smokers at a significance level of 0.05, confidence interval of 95%, an effect size of 0.7, and power of population representation of 0.95. A Descriptive Characteristics Form and SAPS were used to collect the data. The experimental group received eight sessions of cognitive-behavioral therapy-based psychoeducation. No educational program was applied to the control group. The data were analyzed using number, percentage, mean, standard deviation, chi-square, dependent samples t-test and independent samples t-test. Results Substance abuse proclivity was determined in adolescents who smoked cigarettes in the experimental and control groups. The SAPS total score average of the individuals in the experimental group decreased after psychoeducation compared to before psychoeducation. The difference between the posttest SAPS total mean scores of the control and experimental groups was statistically significant. Conclusion CBT-based psychoeducation was found to be effective in reducing substance use proclivities in adolescent smokers.