The coupled aerodynamic performance influence of multiple deviations in the blade profile is a complex phenomena. In this paper, a high-pressure compressor rotor blade mid-span profile is studied with the design of experiments (DOE), numerical simulation and surrogate model to analyze the influence of the deviations on the blade aerodynamic performance. The purpose of this work is to provide a new rapid evaluation approach for the blade aerodynamic performance under multiple geometric deviations influence. First, the Hicks-Henne function was used to model the local geometric deviations of the blade profile, and the blade aerodynamic performance was calculated by using the computational fluid dynamics tools. By analyzing the calculation results, the momentum thickness of the boundary layer, the deviations height and the distance between the deviations are combined into a coupled effect model. Then, the coupled effect model was used to rapidly evaluate the blade aerodynamic performance when the two-position local geometric deviations exist on the blade surface. Finally, the evaluated performance were compared with the results predicted by a high-precision surrogate model, which verifies the high accuracy of the coupled effect model in evaluating the positive incidence range of the blade profile.