The sequential multi-block partial least squares (SMB-PLS) is proposed for implementing a multivariate statistical process control scheme. This is of interest when the system is composed of several blocks following a sequential order and presenting correlated information, for instance, a raw material properties block followed by a process variables block that is manipulated according to raw material properties. The SMB-PLS uses orthogonalization to separate correlated information between blocks from orthogonal variations. This allows monitoring the system in different stages considering only the remaining orthogonal part in each block. Thus, the SMB-PLS increases the interpretability and process understanding in the model building (Phase I), since it provides a deep insight about the nature of the system variations. Besides, it prevents any special cause from propagating to subsequent blocks enabling their use in the model exploitation (Phase II). The methodology is applied to a real case study from a food manufacturing process.
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