Due to the significant amount of cost for privately paid passenger to travel the Earth orbit and beyond, orbital space tourism (OST) is not affordable for the general public in the coming decades. Therefore, the second best could be the suborbital space tourism (SST). According to the following facts, SST could be right at the corner: in October 2017, the Saudi Arabia intended to invest 1 billion USD into Virgin Galactic; on December 11, 2019, Blue Origin's New Shepard had a wholly successful 12th flight test mission (NS-12); and then on February 13, 2020, Virgin Galactic's spaceplane SpaceShipTwo, named VSS Unity, has been successfully relocated to its commercial headquarters at Spaceport America. Referring to the possible or potential effects of reusable suborbital launch vehicle (RSLV) trajectory dynamics on the neuro-vestibular system of passenger, this paper studied and discussed the pre-flight passenger screening contents and the related business opportunities for SST. Requirements for the third class medical certificate of the Federal Aviation Administration (FAA) of the USA have been proposed as a major reference. Since the SST is a new emerging market, contents for pre-flight screening of tourist need be rigorous, but could be adjustable based on accumulated flight experience in the future. The related business opportunities, either academic or commercial, in pre-flight training, pre-flight adaption, post-flight adaption, and data analysis, are expected to form a new industry chain gradually from 2020s to 2030s or 2040s.
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