Online research guides are an important service in academic libraries. Many argue for an instructional design approach that prioritizes course or assignment focused guides; however, this does not address how to design effective subject or topic guides that often follow outdated pathfinder structures. This case study outlines one subject library’s approach to redesigning their guides with pedagogy and accessibility at the forefront, demonstrating how to apply best practices articulated for course-based guides to a general setting. It addresses how to design effective subject guides to better facilitate patron browsing, promote the collection, and supplement training for staff at service points.