Subcutaneous injection of metallic mercury is rare and may produce mercury poisoning. Rapid diagnosis and aggressive treatment are usually required. Removal of mercury deposited in soft tissue is a challenging clinical problem. Surgery is usually performed to remove the mercury together with the affected tissue. 1 Zorrilla P. Morales C. Gómez L.A. et al. Intravenous and subcutaneous injection of mercury: an unusual self-injury. J Trauma. 2009; 66: E32-33 Crossref PubMed Scopus (4) Google Scholar , 2 Kayias E.H. Drosos G.I. Hapsas D. et al. Elemental mercury-induced subcutaneous granuloma. A case report and review of the literature. Acta Orthop Belg. 2003; 69: 280-284 PubMed Google Scholar , 3 Yotsuyanagi T. Yokoi K. Sawada Y. Facial injury by mercury from a broken thermometer. J Trauma. 1996; 40: 847-849 Crossref PubMed Scopus (18) Google Scholar , 4 Zupanc O. Zupanc T. Brvar M. et al. Arthroscopic treatment of knee joint injury for intraarticular mercury form a broken thermometer. Arch Orthop Trauma Surg. 2008; 128: 979-983 Crossref PubMed Scopus (5) Google Scholar , 5 Vernon S.E. Case report: subcutaneous elemental mercury injection-clinical observations and implications for tissue disposal from the histopathology laboratory. Ann Clin Lab Sci. 2005; 35: 86-90 PubMed Google Scholar , 6 Krohn I.T. Solof A. Mobini J. et al. Subcutaneous injection of metallic mercury. JAMA. 1980; 243: 548-549 Crossref PubMed Scopus (40) Google Scholar However, surgical removal is laborious, invasive, and may fail, even under fluoroscopic guidance, because the mercury tends to disperse over a wide area. 1 Zorrilla P. Morales C. Gómez L.A. et al. Intravenous and subcutaneous injection of mercury: an unusual self-injury. J Trauma. 2009; 66: E32-33 Crossref PubMed Scopus (4) Google Scholar In this report, we describe a fluoroscopy-guided percutaneous aspiration technique for removing mercury deposited in soft tissue from a broken thermometer.