Subcutaneous Fat Percentage Research Articles

Body fat distribution and bone mineral density in a multi-ethnic sample of postmenopausal women in The Malaysian Cohort

SummaryIn this study of postmenopausal women in Malaysia, total adiposity was inversely associated with total BMD, while regional associations varied. No differences were detected across Malay, Chinese, and Indian ethnicities. Low BMD contributes substantially to morbidity and mortality, and increasing adiposity levels globally may be contributing to this.PurposeTo investigate associations of total and regional adiposity with bone mineral density (BMD) among a multi-ethnic cohort of postmenopausal women.MethodsDual X-ray absorptiometry (DXA) imaging was undertaken for 1990 postmenopausal women without prior chronic diseases (30% Malay, 53% Chinese, and 17% Indian) from The Malaysian Cohort (TMC). The strength of the associations between standardized total and regional body fat percentages with total and regional BMD was examined using linear regression models adjusted for age, height, lean mass, ethnicity, education, and diabetes. Effect modification was assessed for ethnicity.ResultsWomen with a higher total body fat percentage were more likely to be Indian or Malay. Mean (SD) BMD for the whole-body total, lumbar spine, leg, and arm were 1.08 (0.11), 0.96 (0.15), 2.21 (0.22), and 1.36 (0.12) g/cm2, respectively. Total body and visceral fat percentage were inversely associated with total BMD (− 0.02 [95% CI − 0.03, − 0.01] and − 0.01 [− 0.02, − 0.006] g/cm2 per 1 SD, respectively). In contrast, subcutaneous and gynoid fat percentages were positively associated with BMD (0.007 [0.002, 0.01] and 0.01 [0.006, 0.02] g/cm2, respectively). Total body fat percentage showed a weak positive association with lumbar BMD (0.01 [0.004, 0.02]) and inverse associations with leg (− 0.04 [− 0.06, − 0.03]) and arm (− 0.02 [− 0.03, − 0.02]) BMD in the highest four quintiles. There was no effect modification by ethnicity (phetero > 0.05).ConclusionTotal adiposity was inversely associated with total BMD, although regional associations varied. There was no heterogeneity across ethnic groups suggesting adiposity may be a risk factor for low BMD across diverse populations.

Pengukuran Komposisi Tubuh dalam Upaya Deteksi Obesitas pada Laki-laki dan Perempuan Usia Produktif di SMA Kalam Kudus II, Kelurahan Duri Kosambi, Jakarta

This community service evaluated body composition in men and women of productive age at Kalam Kudus II Senior High School, Duri Kosambi, Jakarta. This community service study included 68 respondents. Measurements were carried out using a body composition scae to assess percentage of total fat, visceral fat, subcutaneous fat and total muscle. The results showed that the 51-64 year age group had the highest percentage of total and visceral fat, while the 18-35 year age group had the highest percentage of total muscle. These findings emphasize the importance of routine body composition monitoring for early detection and appropriate intervention to prevent obesity and metabolic disease. Recommended interventions include a balanced diet, increased physical activity, and health education focused on weight management and healthy body composition. The use of body composition analysis technology can provide more accurate data to support effective and measurable health programs among the productive age group.

Cardiovascular autonomic evaluation and body fat analysis in COVID-19-recovered patients in Dakshina Kannada, India.

The pandemic, coronavirus disease 2019 (COVID-19) has led to a heavy toll on the human health. The aim of this study was to determine the influence of body fat distribution, evolving long-term effect on autonomic function, and its correlation with Chalder Fatigue Severity Score in post-COVID-19-recovered individuals of Indian ethnicity. A case-control study was conducted in the Department of Physiology on 31 cases and 29 age- and gender-matched controls. Cardiovascular evaluation including heart rate variability (HRV), galvanic skin response (GSR), body fat analysis, and Chalder Fatigue Severity Score was performed on the study participants. The continuous variables of basal anthropometric parameters, GSR values, HRV indices, and body fat parameters are expressed as mean and standard deviation (SD). Diastolic blood pressure (DBP) was significantly increased among cases (P = 0.04). GSR (average) for cases is higher when compared to controls and was borderline significant (P = 0.05). There were no statistically significant differences in the HRV parameters. Cases showed significantly higher body fat distribution as compared to the control group indicating increased susceptibility of the obese population to COVID-19. Chalder's post-COVID-19 Fatigue Severity Score of cases showed a negative correlation with LF:HF and RMSSD but it was not statistically significant. In our study, we conclude that there was a significant increase in DBP and GSR (average) with significantly higher visceral fat percentage, body fat percentage, subcutaneous fat percentage, skeletal muscle percentage, and trunk fat percentage in cases as compared to the control group suggestive of higher propensity of obese individuals suffering from COVID-19 and resulting in dysautonomia as compared to the controls.

Correlation between subcutaneous adipose tissue of the head and body mass index in children and young adults aged 8-19 years: implications for functional neuroimaging.

High body mass index (BMI) is presumed to signify high amounts of fat (subcutaneous adipose tissue) distributed across the body. High amounts of fat co-occurring with increased BMI has been cited as a potential neuroimaging barrier. Presence of increased fat may result in high electrical impedance and increased light diffusion-resulting in low signal to noise ratios during electroencepholography (EEG), functional near-infrared spectroscopy (fNIRS), and transcranial direct current stimulation (tDCS) measurements. Examining if subcutaneous fat in the head increases with respect to total body fat percentage and BMI in school-aged children and adolescents is an essential next step in developing possible mathematical corrections for neuroimaging modalities. We hypothesized that percentage of subcutaneous adipose tissue in the head region would increase with respect to both total body fat percentage and BMI. Increased subcutaneous head fat percentage was associated with a positive linear relationship with BMI and a quadratic relationship with total body fat. The data indicate that participant age, sex, and adiposity should be considered in the development of model corrections for neuroimaging signal processing in school-aged children and adolescents. Strength of regression coefficients in our models differed from those in adults, indicating that age-specific models should be utilized.

Sarcopenic Obesity and Its Impact on Quality of Life: A Concise Review.

The presence of sarcopenia and obesity is a feature of sarcopenic obesity (SO). In this condition, the fat-to-lean body mass ratio is incorrect. Excess visceral fat, the percentage of body fat, subcutaneous fat, and body mass index causes poor health and premature death and has been linked to conditions such as type 2 diabetes, ischemic heart disease, high blood pressure, and several types of cancer. In addition, control, autonomy, self-actualization, and enjoyment are all components of quality of life; factors that reduce these aspects are likely to reduce the quality of life in older adults. This reviews paper aims to examine the available evidence regarding the prevalence of quality of life in other conditions, which helps medical professionals and physical therapists by providing abundant knowledge and suggesting the best ways to improve the same.

Perch essence prevents cell death to improve skeletal muscle mass and strength: Evidence from in vitro and human model

Background:Fish protein supplementation may maintain muscle strength and prevent sarcopenia as it contains a complex array of macro- and micronutrients essential for building the skeletal muscle. Objective:The aim of this study was to evaluate the influence of perch essence (PE) supplementation on muscle mass and muscle function of through human and cell model. Methods:The open label clinical trial was conducted to assess the therapeutic effect of PE on muscle mass improvement. The mouse skeletal muscle cell (C2C12) model of muscle atrophy was analyzed for cell viability. Results:Our results showed PE contained abundant branched chain amino acid, taurine, hydroxyproline and collagen. After one month of supplementation with PE in our human model, there was a significant increase in muscle mass in the whole body and all parts of the body, with an increase of 1.55 % in the whole body, 1.79% in the trunk, 1.64% in the arms and 1.38% in the legs. The percentage of subcutaneous fat in the trunk, arms and legs also decreased significantly by 2.49%, 3.21% and 3.40% respectively. PE supplementation also improves muscle grip strength, especially with the dominant hand. The cell model results demonstrated that PE could effectively prevent skeletal muscle cell from death induced by dexamethasone. Conclusion:This study suggests that the branched chain amino acids, taurine, hydroxyproline and collagen in PE have the potential to serve as a good source of dietary supplements for the improvement of skeletal muscle mass and strength through cell protection.Keywords:branched chain amino acid, collagen, perch, skeletal muscle, sarcopenia

A novel candidate gene CLN8 regulates fat deposition in avian

BackgroundThe fat deposition has a crucial role in animal meat flavor, and fat deposition-related traits are vital for breeding in the commercial duck industry. Avian fat-related traits are typical complex phenotypes, which need a large amount of data to analyze the genetic loci.ResultsIn this study, we performed a new phenotypic analysis of fat traits and genotyped whole-genome variations for 1,246 ducks, and combed with previous GWAS data to reach 1,880 ducks for following analysis. The carcass composition traits, subcutaneous fat weight (SFW), subcutaneous fat percentage (SFP), abdominal fat weight (AFW), abdominal fat percentage (AFP) and the body weight of day 42 (BW42) for each duck were collected. We identified a set of new loci that affect the traits related to fat deposition in avian. Among these loci, ceroid-lipofuscinosis, neuronal 8 (CLN8) is a novel candidate gene controlling fat deposition. We investigated its novel function and regulation in avian adipogenesis. Five significant SNPs (the most significant SNP, P-value = 21.37E−12) and a single haplotype were detected in the upstream of CLN8 for subcutaneous fat percentage. Subsequently, luciferase assay demonstrated that 5 linked SNPs in the upstream of the CLN8 gene significantly decreased the transcriptional activity of CLN8. Further, ATAC-seq analysis showed that transcription factor binding sites were identified in a region close to the haplotype. A set of luciferase reporter gene vectors that contained different deletion fragments of the CLN8 promoter were constructed, and the core promoter area of CLN8 was finally identified in the −1,884/−1,207 bp region of the 5′ flanking sequences, which contains adipogenesis-related transcription factors binding sites. Moreover, the over-expression of CLN8 can remarkably facilitate adipocyte differentiation in ICPs. Consistent with these, the global transcriptome profiling and functional analysis of the over-expressed CLN8 in the cell line further revealed that the lipid biosynthetic process during the adipogenesis was significantly enriched.ConclusionsOur results demonstrated that CLN8 is a positive regulator of avian adipocyte differentiation. These findings identify a novel function of CLN8 in adipocyte differentiation, which provides important clues for the further study of the mechanism of avian fat deposition.

The association between sleep duration and detailed measures of obesity: A cross sectional analysis in the ADDITION-PRO study.

Sleep duration is associated with BMI and waist circumference. However, less is known about whether sleep duration affects different measurements of obesity differently. To investigate the association between sleep duration and different measures of obesity. In this cross-sectional analysis 1309, Danish, older adults (55% men) completed at least 3days of wearing a combined accelerometer and heart rate-monitor for assessing sleep duration (hours/night) within self-reported usual bedtime. Participants underwent anthropometry and ultrasonography to assess BMI, waist circumference, visceral fat, subcutaneous fat, and fat percentage. Linear regression analyses examined the associations between sleep duration and obesity-related outcomes. Sleep duration was inversely associated with all obesity-related outcomes, except visceral-/subcutaneous-fat-ratio. After multivariate adjustment the magnitude of associations became stronger and statistically significant for all outcomes except visceral-/subcutaneous-fat-ratio, and subcutaneous fat in women. The associations with BMI and waist circumference demonstrated the strongest associations, when comparing standardized regression coefficients. Shorter sleep duration were associated with higher obesity across all outcomes except visceral-/subcutaneous-fat-ratio. No specifically salient associations with local or central obesity were observed. Results suggest that poor sleep duration and obesity correlate, however, further research is needed to conclude on beneficial effects of sleep duration regarding health and weight loss.

Correlation between subcutaneous adipose tissue of the head and body mass index: Implications for functional neuroimaging.

High body mass index (BMI) is generally assumed to represent overall amounts of body adipose tissue (fat). Increased adipose tissue amounts in persons with increased BMI has been cited as a barrier to assessment of body tissues such as muscle. Significant increases in the amount of adipose tissue between the dermal layer and the skull may result in high electrical impedance and/or increased light diffusion causing a lower signal to noise ratio during use of neuroimaging tools such as electroencepholography (EEG), transcranial direct current stimulation (tDCS), and functional near infrared spectroscopy (fNIRS). Investigating how subcutaneous adipose tissue in the head region increases with respect to total body fat percentage and BMI is an important step in developing mathematical corrections in neuroimaging measurements as BMI increases, as recommended in other measurement modalities such as electromyography (EMG). We hypothesized that percentage of subcutaneous adipose tissue in the head region would increase with respect to both total body fat percentage and BMI. A statistically significant increase in subcutaneous head fat percentage occurred with increased BMI and total body fat percentage. The data investigated in this study indicate that participant age, sex, and BMI are important features to consider in model corrections during data signal processing and analyses for subcutaneous head fat in neuroimaging approaches. The data in this project serve to provide physiological justification for this practice along with regression analyses to be considered for physiologically-based signal to noise correction algorithms.

Effects of Fatty-Type and Lean-Type on Growth Performance and Lipid Droplet Metabolism in Pekin Ducks.

The reasons for differences in lipid depositions between fatty-type (F-T) and lean-type (L-T) ducks remain unknown. The present study aimed to compare the growth performance, lipid deposition, and gene expression related to lipid droplet formation in F-T and L-T Pekin ducks. One-day-old, 140 each L-T and F-T male ducks were selected and distributed separately into 20 replicate cages. All ducks were fed commercial diets up to 35 d of age. F-T ducks had a higher average daily gain from 21 to 28 d of age. On 35-day-old, F-T ducks had higher serum levels of high- and low-density lipoprotein cholesterol, cholesterol, albumin, and hydroxybutyrate dehydrogenase activity than L-T ducks. F-T ducks had higher abdominal fat and subcutaneous fat percentages than those in L-T ducks. Liver histological examination showed that L-T ducks contained more lipid droplets in the liver, which gradually decreased with increasing age. The average adipocyte area and diameter of abdominal fat and subcutaneous fat in the F-T and L-T ducks increased with age and were higher in F-T ducks than those in L-T ducks. Furthermore, the gene expression of perilipin 1, perilipin 2, angiopoietin-like protein 4, adipose triglyceride lipase, alpha/beta-hydrolase domain-containing protein 5 (ABHD5), and serine/threonine kinase 17a in the liver, abdominal fat, and subcutaneous fat of F-T ducks was higher than that in L-T ducks, and it increased with age. Compared to L-T ducks, F-T ducks had higher expression of ABHD5 in the abdominal fat and subcutaneous fat and lower expression in the liver. Thus, F-T ducks displayed lower hepatic lipid deposition and a higher percentage of abdominal fat and subcutaneous fat, suggesting that F-T ducks had higher lipid storage capacity due to increased gene expression related to lipid droplets.

Associations Between Maternal Lipid Blood Levels at the 13th Week of Pregnancy and Offspring's Adiposity at Age 11-12 Years.

ContextThere is increasing evidence that intrauterine lipid metabolism influences the adiposity of the newborn and the first years thereafter. It remains unclear if these effects persist when these children grow older.ObjectiveThis study examined the associations between maternal lipid blood levels during the 13th week of pregnancy and an offspring’s adiposity, measured at age 11-12, and if these associations were moderated by the child’s sex.MethodsData were obtained from a community-based birth cohort, the Amsterdam Born Children and their Development (ABCD) study. At a median of 13 weeks’ gestation, nonfasting blood samples of triglycerides (TGs), total cholesterol (TC), free fatty acids (FFAs), and apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) were measured. An offspring’s body mass index (BMI), subcutaneous fat (SCF), waist-to-height-ratio (WHtR), and fat percentage (fat%) were measured at age 11-12. Mothers with at-term born children were included (n = 1853). Multivariable linear regression analyses were performed to assess the associations between maternal lipids and each offspring’s adiposity outcome separately. Sex differences were additionally evaluated.ResultsTGs, TC, ApoB/ApoA1, and FFAs were significantly positively associated with BMI, WHtR, and fat% (adjusted for gestational age at blood sampling, child’s age, sex, and sexual maturation). After additional adjustments for potential confounders and covariates, only TGs remained significantly associated with WHtR (0.45, 95% CI –0.007; 0.91). There were no associations between maternal lipids and SCF and no clear sex-specific results were found.ConclusionOverall, our results do not strongly support that maternal lipid profile during the 13th week of pregnancy has programming effects on adiposity in preadolescence.

Different Models of Dual-Energy Bone DXA Scanners: A Comparative Study

Background. Dual-energy X-ray absorptiometry (DXA) is an effective method for bone mineral density (BMD) and subcutaneous fat percentage estimation. The constant development of new densitometry techniques, the demographic change and the higher potential of artificial intelligence in healthcare enhance requirements for the high-quality measurements in DXA.
 This study aimed to develop a quality control method for DXA scanners and compare four DXA systems with different X-ray geometries and manufacturers when simulating fat-water environments.
 Methods. We evaluated the accuracy (relative error (%) and precision (CV%)) of the bone mineral density (BMD) measurements, performed by the four DXA scanners: 2 with narrow-angle fan beam (64- and 16-channel detectors (DXA-1, DXA-2)); 1 with wide-angle fan beam (DXA-3); 1 with pencil beam (DXA-4). We used a PHK (PHantom Kalium) designed to imitate spine. The PHK contained four vertebras filled with a K2HPO4 solution in various concentrations (50-200 mg/ml). The PHK also included paraffin patches (thickness 40 mm) to simulate the fat layer.
 Results. DXA-1 and DXA-2 demonstrated the best CV% ranged from 0.56% to 1.05%. The least % was observed when scanning PHK with fat layer on DXA-1 and DXA-2 (1.74% and 0.85%) and DXA-4 (1.47%). DXA-3 produced significantly lower BMD ( = -14.56%, p = 0.000). After removing the fat layer, we observed reduction (p = 0.000) of BMD for DXA- 1 and DXA-2 ( = -5.11% and -6.12% respectively) and weak deviation (p = 0.80) for DXA-4 (0.87%). For DXA-3, removal of the fat layer also resulted in a significant reduction in BMD ( = -16.44%, p = 0.000). The subcutaneous fat modeling showed that all these DXA systems automatically determine the percentage of fat in the scanned area with weak underestimation: for DXA-1, DXA-2 and DXA-4 the % were -5,9%, -6,3% and -2,3% respectively. CV% were 0.15%; 0.39%; 1.6%, respectively.
 Conclusions. We proved a significant underestimation of the BMD measurements across the entire range of simulated parameters for the DXA scanners when the model did not include the subcutaneous fat layer. All models demonstrated high accuracy in measuring the fat layer, with the exception of the DXA-3 model, which was not assessed in these studies.

Abstract 65: Effects of gender affirming hormone therapy on metabolic health and body composition in gender dysphoria

Background: Gender affirming hormone therapy (GAHT) may impact metabolic health and body composition in individuals with gender dysphoria.Aims and Objectives: The aim of this cross-sectional study was to investigate the effects of GAHT on metabolic health (HOMA2-IR and lipid parameters) and body composition [BIA (Bioelectrical impedance analysis)] in transgender individuals. They were divided into 4 groups: Group 1 (n=38) and Group 3 (n=12) consisted of treatment naïve transwomen and transmen while group 2 (n=7) and group 4 (n=22) consisted of transwomen and transmen on treatment for at least 6 months, respectively.Results: The groups 1 and 4 showed significant differences in FBG (fasting blood glucose), whole-body and subcutaneous fat and skeletal muscle percentages; (p<0.005) (cisgender setting). The visceral, subcutaneous fat and skeletal muscle percentages were also found to be different (p<0.01) (transgender setting). When groups 2 and 3 were compared, differences between TG, VLDL, subcutaneous fat and skeletal muscle percentages (cisgender setting) (p<0.05) were significant.Conclusions: Transmen on GAHT were found to have lower fasting glucose, skeletal muscle mass and higher whole-body and subcutaneous fat as compared to natal men. Transwomen on GAHT were found to have higher TG, VLDLC, skeletal muscle mass and lower subcutaneous fat compared to natal women.

Anthropometry, body composition and hand grip strength of select female athletes from Chennai, India

This was a cross-sectional study, conducted from March to December 2021. Purposive sampling was used to select 154 female athletes aged 18 to 23 years from various colleges and sports organisations. The participants were involved in athletics, ball sports, racquet sports, field sports and other sports such as boxing, fencing, kho-kho, taekwondo and swimming. Height, body weight, body mass index, waist and calf circumferences, waist to height ratio, total fat, subcutaneous fat and visceral fat percentages, muscle mass percentage, resting metabolic rate, and hand grip strength of all participants were recorded. Height (163.1 ± 8.0 cm; p&lt;0.01) and body weight (60 ± 10 kg; p&lt;0.05) of ball sport athletes was significantly higher compared to other participants. Highest calf circumference (34.5 ± 3.2 cm) was seen among racquet sport players. Participants involved in athletics had significantly higher muscle mass percentage (28.6 ± 2.2; p&lt;0.01), lower total body fat percentage (24.7 ± 4.7; p&lt;0.01) and lower subcutaneous fat percentage (21.1 ± 4.6; p&lt;0.05). All athletes showed normal hand grip strength values. Regular assessment of these parameters is important for athletes to ensure their fitness for training, thereby improving performance and delaying the onset of fatigue during competitions.

Correlation of dietary intake and physical activity with nutritional status, body composition and hand grip strength in elderly

ABSTRACT Background: Increased life expectancy has both positive and negative impacts. Elderly group are prone to nutritional issues and body function disorder such as sarcopenia. Factors including dietary intake and physical activity are contributors of sarcopenia.Objectives: The purpose of this study is to analyze the correlation of dietary intake and physical activity with nutritional status, body composition and hand grip strength (HGS) in elderly.Materials and Methods: The study was held on July-October 2020 at the Panti Wredha Dharma Bakti Surakarta. This was a cross-sectional study of 54 elderly subjects. Subjects were selected by purposive sampling method. The data included height was measured using microtoise, while weight and body composition was measured using Bioelectrical Impedance Analyzer (BIA). Dietary intake was obtained through comstock observation. Physical activity was measured by the International Physical Activity Questionnaire. Hand grip strength values was measured by hand grip dynamometer. Data normality analyzed by Kolmogorov-Smirnov test. Bivariate test analyzed by Rank Spearman test.Results: Energy, carbohydrate and fat intake had no correlation with nutritional status, total body fat percentage, subcutaneous fat percentage and skeletal muscle mass percentage (p value &gt; 0.05), but there was a relationship between energy (p value = 0.33), carbohydrate (p value = 0.016) and fat intake (p value = 0.047) with visceral fat percentage. Physical activity had relation with nutritional status (p = 0.048) but had no relationship with total body fat percentage, visceral fat percentage, subcutaneous fat percentage and skeletal muscle mass percentage. Protein intake also had no relationship with HGS value (p value&gt; 0.05).Conclusions: Dietary intake only correlated with visceral fat percentage, but had no correlation with other body composition parameters. Physical activity correlated with nutritional status, but had no correlation with all of body composition parameters. Protein intake also had no correlation with HGS.

Differences in anthropometric variables and muscle strength in relation to competitive level in male handball players.

Somatic characteristics manifested in different body morphology have great importance for the selection of athletes in most sports. The aim of our study is to evaluate the differences in anthropometric variables and isometric strength of handball players presenting different levels of sports competence, and to study the discriminative power of selected morphological characteristics that do not change in the training process. The study included the results of anthropometric measurements routinely used to monitor athletes, and body proportion indices were calculated. Fat percentage was assessed using the BIA, whereas body build was assessed using the Heath-Carter method. Measurements of right and left hand grip strength and back strength were taken. The results of measurements and calculations were analyzed using statistical methods. It was shown that players presenting the highest level dominate by the overall size and massiveness of the body, characteristics ensuring an advantage in direct confrontation. The size of subcutaneous fat tissue and percentage of body fat varied poorly between athletes in each group. Muscle strength assessed under static conditions shows a gradient in magnitude across teams from higher to lower rank, but the differences are not statistically significant. The same somatotype (balanced mesomorph) was present in all groups. Athletes presenting high sports level are characterized by body proportions that determine biomechanical conditions conducive to optimizing the structure of movements important in handball. Stepwise discriminant analysis showed that throwing-related characteristics (hand length, upper arm length, upper limb span, lower limb length) account for 88% of the variance in team ranking and can be used to identify the morphological predisposition of adepts to play handball.

Metabolic effects of ramipril and indapamide in hypertensive patients with non-alcoholic fatty liver disease

Objective. To assess the effects of combined antihypertensive therapy with ramipril and indapamide on insulin resistance, carbohydrate, lipid and purine metabolism, as well as the structure and function of the liver in hypertensive patients with non-alcoholic fatty liver disease (NAFLD).Design and methods. In a pre-post study, we included 30 patients with hypertension (HTN) 1–2 degrees in combination with NAFLD (Fatty Liver Index (FLI) &gt; 60) aged 45 to 65 years. Patients discontinued antihypertensive therapy 5–7 days before the initial examination. After that one of the fixed combinations of ramipril (2,5/5 mg/day) and indapamide (0,625/1,25 mg) were prescribed along with the lifestyle and weight reduction recommendations (the Mediterranean type of diet, a decrease in calorie intake by 500–1000 kcal from baseline, and physical aerobic exercise at least 150 minutes per week). All patients underwent clinical examination, measurement of office blood pressure (BP), ambulatory BP monitoring (ABPM), anthropometric parameters, assessment of the visceral obesity index (VAI), anthropometric parameters, VAI, the degree of adipose tissue dysfunction (ATD), the percentage of visceral and subcutaneous fat by the bioelectrical impedance method. We also assessed lipid, carbohydrate, purine metabolism and the structural and functional state of the liver before and after the treatment.Results. After 24-week therapy with a fixed combination of ramipril and indapamide (average dosage of 4,04 ± 1,24 and 1,01 ± 0,31 mg, respectively) HTN patients with NAFLD achieved target BP. There was a decrease in both office systolic BP (SBP) (p &lt; 0,001) and office diastolic BP (DBP) (p = 0,007) in 100 % of patients, as well as in ABPM indices. We observed a decrease in waist and hip circumferences (p ≤ 0,001 and p ≤ 0,001, respectively), the proportion of subcutaneous (p = 0,0134) and visceral (p = 0,002) fat. The number of patients with normal ATD increased (p = 0,030), while the proportion of patients with dysfunction decreased (p = 0,039). There was also a significant increase in high-density lipoprotein cholesterol (p = 0,027) and a decrease in insulin resistance (p = 0,002) and metabolic index (p = 0,030). We also found an improvement in carbohydrate metabolism with no change in purine metabolism. There was a favorable effect on the liver structure and function, and the number of patients with high alaninaminotransferase &gt; 40 U/L decreased (5 (16,7 %) vs 0, p = 0,026).Conclusions. Twenty-fourweek treatment with a fixed combination of ramipril and indapamide, together with recommendations for lifestyle changes and weight loss, led to a significant decrease in BP levels, the severity of insulin resistance, and visceral obesity. In addition, the treatment had a beneficial effect on the parameters of carbohydrate and lipid metabolism, as well as liver structure and function (decreased severity of steatosis and fibrosis).

Pixel-wise body composition prediction with a multi-task conditional generative adversarial network

The analysis of human body composition plays a critical role in health management and disease prevention. However, current medical technologies to accurately assess body composition such as dual energy X-ray absorptiometry, computed tomography, and magnetic resonance imaging have the disadvantages of prohibitive cost or ionizing radiation. Recently, body shape based techniques using body scanners and depth cameras, have brought new opportunities for improving body composition estimation by intelligently analyzing body shape descriptors. In this paper, we present a multi-task deep neural network method utilizing a conditional generative adversarial network to predict the pixel level body composition using only 3D body surfaces. The proposed method can predict 2D subcutaneous and visceral fat maps in a single network with a high accuracy. We further introduce an interpreted patch discriminator which optimizes the texture accuracy of the 2D fat maps. The validity and effectiveness of our new method are demonstrated experimentally on TCIA and LiTS datasets. Our proposed approach outperforms competitive methods by at least 41.3% for the whole body fat percentage, 33.1% for the subcutaneous and visceral fat percentage, and 4.1% for the regional fat predictions.

Waist Circumference and BMI Are Strongly Correlated with MRI-Derived Fat Compartments in Young Adults.

Young adulthood is increasingly considered as a vulnerable age group for significant weight gain, and it is apparent that there is an increasing number of new cases of metabolic syndrome developing among this population. This study included 60 young adult volunteers (18–26 years old). All participants obtained a calculated total abdominal fat percentage, subcutaneous fat percentage, and visceral fat percentage using a semiautomatic segmentation technique from T1-weighted magnetic resonance imaging (MRI) images of the abdomen. The results show strongest correlation between abdominal fat and BMI (r = 0.824) followed by subcutaneous fat (r = 0.768), and visceral fat (r = 0.633) respectively, (p < 0.001 for all, after having been adjusted for age and gender). Among anthropometric measurements, waist circumference showed strong correlation with all fat compartments (r = 0.737 for abdominal, r = 0.707 for subcutaneous fat, and r = 0.512 for visceral fat; p < 0.001 for all). The results obtained from examining the blood revealed that there was a moderate positive correlation relationship between all fat compartments with triglyceride, high-density lipoprotein, and fasting glucose levels (p < 0.05 for all). This study suggests that both BMI and waist circumference could be used to assess the fat compartments and treatment targets to reduce the risk of metabolic disorders and health risks in the young adult population.

Effect of nuciferine on gut microbiota and inflammatory response in obese model mice

The aim of this study was to elucidate the mechanism of nuciferine on alleviating obesity based on modulating gut microbiota, ameliorating chronic inflammation, and improving gut permeability. In this study, the obese model mice were induced by high-fat diet and then randomly divided into model group, and nuciferine group; some other mice of the same week age were fed with normal diet as normal group. In the modeling process, the mice were administered intragastrically(ig) for 12 weeks. In the course of both modeling and treatment, the body weight and food intake of mice in each group were measured weekly. After modeling and treatment, the Lee's index, weight percentage of inguinal subcutaneous fat, and the level of blood lipid in each group were measured. The pathological changes of adipocytes were observed by HE staining to evaluate the efficacy of nuciferine treatment in obese model mice. 16 S rRNA sequencing analysis was conducted to study the changes in diversity and abundance of gut microbiota after nuciferine treatment. Enzyme-linked immunosorbent assay(ELISA) and quantitative Real-time polymerase chain reaction(qPCR) were used to detect the levels of inflammatory factors interleukin-6(IL-6), interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and the expression of related genes in adipose tissue of mice in each group, so as to evaluate the effect of nuciferine on chronic inflammation of mice in obese model group. qPCR was used to detect the expression of occludin and tight junction protein 1(ZO-1)gene in colon tissure, so as to evaluate the effect of nuciferine on intestinal permeability of mice in obese group. Nuciferine decreased the body weight of obese mice, Lee's index, weight percentage of inguinal subcutaneous fat(P&lt;0.05), and reduced the volume of adipocytes, decreased the level of total cholesterol(TC), triglyceride(TG), and low density lipoprotein cholesterol(LDL-C)(P&lt;0.05) in serum, improved dysbacteriosis, increased the relative abundance of Alloprevotella, Turicibacter, and Lactobacillus, lowered the relative abundance of Helicobac-ter, decreased the expression of inflammatory cytokines IL-6, IL-1β, and TNF-α genes in adipose tissue(P&lt;0.01), decreased the levels of inflammatory cytokines IL-6, IL-1β, and TNF-α in serum(P&lt;0.05), and increased the expression of occludin and ZO-1 genes related to tight junction in colon tissue(P&lt;0.01). Nuciferine could treat obesity through modulating gut microbiota, decreasing gut permeability and ameliorating inflammation.