Subcapsular Hepatic Hematoma Research Articles

Rescue of a spontaneous subcapsular hepatic hematoma associated with HELLP syndrome: A case report.

Spontaneous subcapsular hepatic hematoma (SSHH) is a rare yet severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome that can lead to life-threatening situations for both the mother and fetus. Determining an appropriate therapeutic strategy remains challenging, as it involves choosing between surgery, microinvasive percutaneous transhepatic drainage, or conservative treatment alone. Further successful cases are needed to support the optimal option. We retrospectively collected a patient's clinical record and imaging data to elucidate the natural progression, response to noninvasive treatment, and outcome of SSHH associated with HELLP syndrome. A 34-year-old woman, who underwent a cesarean section due to suspected fetal distress, developed SSHH accompanied by the potential risk of rupture and deteriorated serology within the first 24 hours after delivery. Emergency blood routine examination, serum biochemistry analysis, and computed tomography of the abdomen revealed a SSHH associated with HELLP syndrome. The main rescue measures included the use of corticosteroids, antihypertensive drugs, and platelet transfusion. A positive effect on the patient's condition was exhibited within 24 to 48 hours. The majority of the subcapsular hepatic hematoma could be absorbed without any sequelae over a period of 7 months. For patients with pregnancy-induced hypertension, there is a heightened risk of HELLP syndrome occurrence in subsequent pregnancies. The assessment and treatment of SSHH should be conducted by an experienced multidisciplinary team. In addition to timely delivery, the administration of corticosteroids, usage of antihypertensive medication, and platelet transfusion are necessary, particularly within the first 48 hours if the patient's condition permits. This approach would provide valuable insights for further therapeutic decisions and facilitate a preliminary prognosis assessment.

A case report of hepatic subcapsular hematoma: Newborn with an autoimmune hemolytic condition.

We report a case of hepatic subcapsular hematoma in a newborn baby detected with an autoimmune hemolytic condition due to ABO incompatibility. Magnetic resonance imaging could be helpful in differentiating hepatic subcapsular hematoma from other abdominal masses.

Hepatic compartment syndrome, a rare complication after any liver insult or liver transplantation: Three case reports and literature review.

Hepatic compartment syndrome (HCS) is a rare but life-threatening entity that consists of a decreased portal flow due to intraparenchymal hypertension secondary to subcapsular liver hematoma. Lethal liver failure can be observed. We report three cases, and review the literature. A 54-year-old male was admitted for extensive hepatic subcapsular hematoma after blunt abdominal trauma. Initially, he underwent embolization of the hepatic artery's right branch, after which he presented clinical deterioration, major cytolysis (310 times the upper limit of normal [ULN]), and liver failure with a prothrombin time (PT) at 31.0%. A 56-year-old male underwent liver transplantation for acute alcoholic hepatitis. On postoperative day 2, he presented a hemorrhagic shock associated with deterioration of liver function (cytolysis 21 ULN, PT 39.0%) due to extensive hepatic subcapsular hematoma. A 59-year-old male presented a hepatic subcapsular hematoma five days after a cholecystectomy, revealed by abdominal pain with liver dysfunction (cytolysis 10 ULN, PT 63.0%). All patients ultimately underwent urgent surgery for liver capsule excision, hematoma evacuation, and liver packing, if needed. The international literature was screened for this entity. These three patients' outcomes were favorable, and all were alive at postoperative day 90. The literature review found 15 reported cases. HCS can occur after any direct or indirect liver trauma. Surgical decompression is the main treatment, and there is probably no place for arterial embolization, which may increase the risk of liver necrosis. A 13.3% mortality rate is reported. HCS is a rare complication of subcapsular liver hematoma that compresses the liver parenchyma, and leads to liver failure. Urgent surgical decompression is needed.

Spontaneously ruptured huge hepatic subcapsular hematoma associated with preeclampsia: A case report and literature review.

Hepatic subcapsular hematoma (HSH) is an uncommon complication of pregnancy and is associated with elevated rates of maternal and foetal mortality. The rupture of an HSH is a critical situation that necessitates immediate and timely intervention to prevent loss of life. We present here, a case of a spontaneously ruptured massive HSH caused by preeclampsia. In addition, we conducted a comprehensive review of existing literature, encompassing 49 cases of HSH associated with pregnancy. If a pregnant woman with gestational hypertension experiences right upper abdominal pain with shoulder pain or radiating shoulder pain, it is crucial for her to have an urgent abdominal ultrasound because of the potential development of HSH and/or rupture. Our review of current literature suggests that opting for a caesarean section may offer notable advantages in preventing HSH rupture.

Subcapsular Hepatic Hematoma after the Endoscopic Retrograde Cholangiopancreatography: Clinical Case and Literature Review

Endoscopic retrograde cholangiopancreatography (ERCP) is a minimally invasive procedure to diagnose and treat the biliary tract and pancreas’ diseases. We would like to present a clinical case of a 66­year­old patient, who underwent ERCP due to obstructive jaundice complicated by the subcapsular hematoma, 11.6×4.7×13.4 cm in size according to the computed tomography (CT), and by the left­sided hydrothorax after the hematoma was removed. The patient was successfully treated and discharged on the 15th day after drainage of the pleural cavity. Subcapsular hematoma is a potentially lethal and rare complication that can be treated with a conservative therapy, if diagnosed at an early stage.

Surgical management of spontaneous hepatic rupture associated with HELLP syndrome. Case presentation and literature review

Background: HELLP syndrome is a serious complication in pregnancy characterized by hemolysis, elevated liver enzymes and low platelet count occurring in 0.2 to 0.6% of all pregnancies and in 10–20% of cases with severe preeclampsia. Spontaneous hepatic capsular rupture is a rare (0,015% of all pregnancies), but a life-threatening complication of HELLP syndrome with a mortality rate of up 50% for both mother and infant. Methods: We present the case of a 34-year-old nulliparous woman with a second trimester gestational hepatic rupture associated with HELLP syndrome. A systematic literature search was conducted on database of PubMed, Scopus, Medline and Embase. Results: Spontaneous hepatic rupture is an infrequent but life-threatening condition of pregnancy associated with severe pre-eclampsia and HELLP syndrome. Diagnosis is based on clinical suspicion. Abdominal CT with intravenous contrast is considered to be the best diagnostic method. The management of this pathology requires a multidisciplinary approach between gynecologists, general surgeons and intensive care physicians. The main therapeutic objectives are: eliminate the causal factor, end the pregnancy and control hemorrhage. If there is not hepatic rupture and the patient is hemodynamically stable, conservative nonoperative management for selected patients has been recommended. However, if the patient presents hemodynamic instability despite adequate resuscitation or hemoperitoneum, it has been seen that surgery significantly reduces the mortality associated with this pathology. Conclusions: Hepatic subcapsular hematoma and hepatic rupture are infrequent but life-threatening complications that can occur during pregnancy and are fundamentally related to pathologies such as preeclampsia and HELLP syndrome. The first step is to end the pregnancy and subsequently control the acute liver problem. Different surgical techniques have been described that should be individualized for each patient according to damage control principles. A high index of suspicion and prompt recognition allows a multidisciplinary approach and mortality can be reduced. Study type: Therapeutic/care management.

Subcapsular Hepatic Hematoma Post Endoscopic Retrograde Cholangiopancreatography (ERCP): a case report

Subcapsular hepatic hematoma is a rare complication found after the ERCP, which can lead to abdominal pain, anemia, fever and hypotension. The case of a 34-year-old patient who developed a subcapsular liver hematoma after ERCP is presented in this paper. The patient had abdominal pain and anemia, which did not improve with conservative treatment. Drainage therapy was performed, leading to remission of the condition.

Spontaneous subcapsular hepatic hematoma in pregnant patients.

Spontaneous subcapsular hepatic hematoma (SSHH) with or without previous history of preeclampsia and/or HELLP syndrome represents a very rare pathological condition in pregnancy and postpartum, (1/45,000-1/225,000 pregnancies). Its importance for the anesthesiologist lays in its association with high morbidity and mortality for the mother (60-86%, 39%) and newborn (42%). After a high clinical suspicion, the certainty clinical diagnosis is settled by different imaging techniques. However, in most cases the diagnosis of SSHH is a casual intraoperative finding associated to a maternal or foetal compromise. Nowadays the obstetric and anaesthetic management of a SSHH is not standardized and depends on its integrity, hemodynamic stability and the gestational period when diagnosed. The possibility of an acute critic haemorrhage with necessity of massive transfusion, makes advisable to provide updated protocols for the treatment of obstetric hemorrhage, adapting them to the clinical peculiarities of these patients. After the acute phase, close attention should be kept on thromboembolic complications.

A 39-Year-Old Woman with Endometriosis Who Developed a Subcapsular Liver Hematoma Following Laparotomic Surgical Left Adnexectomy, Rectosigmoid Anastomosis, and Bilateral Ureteral Reimplantation.

BACKGROUND Endometriosis is a chronic inflammatory disease caused by endometrial tissue that grows outside the uterus. Deep endometriosis surgery is associated with considerable rates of complications, although such rates are lower in surgical procedures carried out by expert surgical teams. This report details a case of a rare but life-threatening complication in the postoperative period following 72 h of endometriosis surgery: a giant subcapsular hepatic hematoma, which was successfully managed conservatively. CASE REPORT Here we describe the case of a 39-year-old woman with deep endometriosis with ureteral, ovarian, and intestinal involvement requiring multidisciplinary surgery. She presented with severe anemia, respiratory distress, and oliguria 72 h postoperatively. A 3-phase computed tomography (CT) scan revealed a giant intrahepatic subcapsular hematoma (180×165×50 mm) lateral to the right hepatic lobe, which was managed conservatively. The patient evolved favorably and the hematoma was reduced (77×16 mm) in a follow-up CT scan performed 5 months later. CONCLUSIONS Giant liver hematoma is a rare, life-threatening complication. The current experience relating to its management remains largely limited owing to the rarity of the condition and paucity of published cases. Actually, we found no articles on hepatic hematoma in the context of endometriosis surgery. Early diagnosis and treatment are essential to reduce the patient's risk of death. Imaging diagnosis plays an essential role.

Guidewire Impaction in the Main Pancreatic Duct in a Patient with Chronic Pancreatitis: A Case Report

The guidewire is an essential accessory in ERCP. Although rare, guidewires can cause complications, such as subcapsular hepatic hematoma, perforation, knotting, fracture, and impaction, during ERCP. This report describes a guidewire impaction during the endoscopic treatment of a patient with symptomatic chronic pancreatitis. The methods used to treat guidewire impaction are not well known. In the present case, the impacted guidewire was retrieved by inserting another guidewire and dilating the space adjacent to it. Endoscopists should check for the free movement of the guidewire before stent deployment. Additionally, it is important to ask for help from experienced senior staff to overcome any challenges during the procedure. In conclusion, endoscopists should be aware of the possibility of a guidewire impaction during ERCP.

A rare case of hepatic subcapsular hematoma presenting with severe anemia in a 20-hour old term newborn: case report

Hepatic subcapsular hematoma is an extremely rare clinical condition in the neonatal period. Being a life-threatening emergency, it requires prompt diagnosis and management. In a newborn presented with severe anemia, hypovolemic shock, and abdominal distention with hemoperitoneum without any identifiable risk factors hepatic subcapsular hematoma should be considered. Newborns may develop catastrophic acute and long-term complications if the diagnosis is not made timely. Obstetricians, pediatricians, neonatologists and pediatric surgeons should have a high of the index of suspicion of hepatic subcapsular hematoma in newborns to avoid delay in the diagnosis and to reduce neonatal morbidity and mortality. 
 Here, we report a 20 hour’s old male term newborn diagnosed with Hepatic Subcapsular Hematoma after he presented with progressive abdominal distension and severe anemia. Abdominal ultra-sound showed a well-defined round heterogenic echogenic liver mass and massive intra-peritoneal fluid collection. The newborn was managed in the Neonatal Intensive Care Unit with Fresh Frozen Plasma transfusion, Whole blood transfusion and vitamin K administration, and discharged im-proved after a week. A high index of clinical suspicion is necessary to avoid delayed diagnosis and life-threatening complications among health professionals in the neonatal intensive care unit.

The conservative management of a large hepatic subcapsular hematoma in a pregnant woman with preeclampsia: A case report

Hepatic subcapsular hematoma is a rare but potentially life-threatening complication that is caused by preeclampsia and hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome, which may be manifest with nonspecific signs and symptoms. The present case was a 36-year-old woman with a secondary subcapsular liver hematoma as a rare complication of HELLP syndrome. The patient complained of nausea, vomiting, pain in the right upper quadrant of the abdomen, epigastric pain, and severe pain in the right shoulder. On the fourth day after delivery, a computed tomography (CT) scan was performed on the patient, showing a large subcapsular hematoma around the liver. Six weeks after delivery, the follow-up ultrasound exhibited no residual hematoma or free peritoneal fluid, and the patient’s blood pressure was controlled without taking medication.

Natural history of hepatic subcapsular hematoma in mild pre-eclampsia.

Natural history of hepatic subcapsular hematoma in mild pre-eclampsia.

Survival After Ruptured Spontaneous Hepatic Subcapsular Hematoma Following Heparin Initiation for Submassive Pulmonary Embolism

Hepatic subcapsular hematomas (HSHs) are rare outside the context of trauma, endoscopic retrograde cholangiopancreatography, and pregnancy. Ruptured HSHs present with abdominal pain and hypotension, with high mortality. We present the patient case of a 69-year-old man readmitted with deep venous thrombosis and pulmonary embolus after uncomplicated laparoscopic prostatectomy. Soon after receiving heparin, he experienced acute abdominal distention and right upper quadrant pain. A large ruptured subcapsular hematoma with focal active bleeding was identified and eventually controlled surgically. We highlight that HSHs can complicate anticoagulant therapy. Awareness and prompt intervention can be lifesaving.

S2858 Post-ERCP Subcapsular Hepatic Hematoma

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is both a diagnostic and therapeutic procedure used for management of biliary pathology. Rates of even the most common complications, including biliary perforation and pancreatitis, are low, however other complications can be life-threatening and must be kept in mind when evaluating a patient post-ERCP. Here, we describe a case of post-ERCP subcapsular hepatic hematoma (SHH). Case Description/Methods: A 39-year-old man with a history of hypertension, type II diabetes mellitus and alcohol use disorder complicated by chronic pancreatitis with multiple episodes of common bile duct (CBD) stricture status post multiple ERCPs presents with epigastric pain and right upper quadrant pain. He was admitted two weeks prior for epigastric pain, where he was found to have CBD stricture, and underwent ERCP with stent placement. Pain did not completely resolve after his last hospitalization and escalated to a 10/10. On arrival, he was afebrile with stable vitals. Physical exam demonstrated epigastric tenderness to palpation with voluntary guarding, but a soft abdomen without rebound tenderness. Labs significant for WBC count of 10.8 x 10^9/L, alkaline phosphatase of 117 U/L, and hemoglobin 11.7 g/dL. Abdominal ultrasound showed a 7.3 x 3.9 cm area of mixed echogenicity in the right liver lobe. Triple phase CT of the abdomen and pelvis showed a 9 x 6.5 x 2.5 cm heterogeneous subcapsular liver collection. He was given Zosyn, and WBCs downtrended. On day 3, liver function tests (LFTs) rose: aspartate aminotransferase was 397 U/L, alanine aminotransferase was 206 U/L, alkaline phosphatase was 571 U/L, and total bilirubin was 5.0 mg/dL. Repeat CT showed expected hematoma resolution with correct biliary stent placement. Antibiotics were re-started. LFTs and symptoms improved. He was discharged on a 14-day course of Levofloxacin and Metronidazole. (Figure) Discussion: SHH is a rare but known complication of ERCP. Hematomas can expand, resulting in significant anemia and LFT elevation, or become infected with resultant sepsis. Patients with SHH must be carefully monitored in the post-ERCP setting. This patient exhibited an elevated WBC count with delayed elevation in LFTs, concerning for potential infection of the hematoma, yet without overt signs of infection, including lack of fever. He was managed with antibiotics without hematoma drainage, demonstrating the efficacy of conservative management for such a potentially deadly complication of ERCP.Figure 1.: Triple phase computed tomography scan of the abdomen and pelvis demonstrating a right-sided subcapsular hematoma in segment 6 of the liver in the coronal (a) and transverse (b) planes (arrow).

S2832 First Trimester Subcapsular Hepatic Hematoma Following Endoscopic Retrograde Cholangiopancreatography

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly utilized to treat pancreaticobiliary diseases and is considered safe in pregnancy. We describe a case of ERCP indicated for choledocholithiasis in a newly pregnant patient which resulted in a very rare complication related to guide wire trauma. Case Description/Methods: A 24-year-old female presented to the emergency department with right upper quadrant pain, fever, leukocytosis, and obstructive jaundice. Bloodwork revealed she was 8 weeks pregnant. Imaging studies showed acute cholecystitis and choledocholithiasis with a dilated common bile duct of 1.2 cm. Therapeutic ERCP was performed with minimal use of fluoroscopy to reduce fetal exposure. Double wire technique was utilized and the bile duct was successfully cannulated with a 0.025 mm angled-tipped hydrophilic wire. Sphincterotomy was performed, followed by sphincteroplasty. The bile duct was swept with a 12 mm balloon but only one stone was extracted. To avoid further fetal fluoroscopy exposure, double plastic stents were placed into the common bile duct and a single pigtail plastic stent was placed into the pancreatic duct. The following day, she became hemodynamically unstable. Labs suggested an improved cholestatic pattern and improved leukocytosis post ERCP decompression. Due to worsening hepatocellular injury and hemodynamic instability, a computed tomography angiogram was performed. A 3.9 cm subcapsular hepatic hematoma with capsular retraction and parenchymal distortion of the superior right hepatic lobe was found. Interventional radiology catheter embolization was attempted. Aggressive conservative management with blood transfusions and close monitoring successfully stabilized the patient. The patient ultimately had a spontaneous abortion and returned for an outpatient ERCP with biliary stent removal and stone extraction. Discussion: Although a very rare complication, this case does highlight the possibility of angled-tipped hydrophilic guide wire hepatic trauma and clinically significant bleeding. When strongly indicated, ERCP should be performed in people who are pregnant, but exposure to fluoroscopy should be minimized. Similar cases hypothesize that liver injury is attributable to traumatic damage to the intrahepatic biliary tree and hepatic parenchyma by the ERCP guide wire.Figure 1.: Computed tomography of the abdomen revealed a hypodense subcapsular collection on the right side of the liver. The bleed continues inferiorly and medially. A plastic pancreatic stent and a plastic biliary stent are also visible.

S3162 Subcapsular Hepatic Hematoma: A Rare Complication of Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome in Pregnancy

Introduction: Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is seen in 0.1-1.0% of pregnant people overall, with the risk increased by preeclampsia. Common complications of HELLP include bleeding, disseminated intravascular coagulation (DIC), and abruptio placentae. Here we present a rare case of subcapsular liver hematoma that occurs in only 1% of HELLP patients. Case Description/Methods: A 29-year-old woman, gravida 4, para 3 with a history of preeclampsia during prior pregnancies presents with acute onset epigastric and pelvic pain for one day at 27th-week gestation. The severe, intermittent epigastric pain radiates laterally down to the pelvis and is aggravated with laying down. The review of systems and vitals were normal. Mild tenderness in the right upper quadrant (RUQ) was noted. Labs showed high ALT 233 U/L, AST 378 U/L, low platelet 108,000/microL, and high LDH 519 IU/L. The rest of the labs were normal. She underwent an emergent C-section at admission for HELLP syndrome. An ultrasound showed two complex hypoechoic hepatic mass-like areas measuring 9.3cm and 3.5 cm in the setting of hepatomegaly and diffuse hepatic steatosis suggestive of focal fatty sparing or cavernous hemangioma. Biliary sludge without cholecystitis or cholelithiasis was also noted. An MRI with IV contrast with the liver mass protocol was obtained which showed hepatic subcapsular hematoma of dimensions 24 cm x 9.2 cm x 3.9 cm at the level of the right hepatic lobe. The pain continued to worsen with a drop in hemoglobin from 12.8 gm/dl at admission to 7.1 gm/dl on day 4. IR was consulted for rupture concern and recommended CT angiography of abdomen and pelvis with and without arterial/venous phase that showed similar appearing subcapsular hematoma without an active bleed. Underwent image-guided hepatic angiography that showed large perihepatic hematoma along the right lateral abdominal wall without active contrast extravasation. Right hepatic artery embolization was done with a reduction in peripheral hepatic arterial blood flow by 25%. Later hemoglobin stabilized, liver enzymes improved, and the patient was discharged home 6 days later in a clinically stable state (Figure). Discussion: Early diagnosis of subcapsular hematoma is challenging due to nonspecific signs and symptoms but crucial for improved outcomes. Physicians should evaluate for a subcapsular hematoma in patients with HELLP and RUQ pain or hypotension. Therapeutic options for ruptured hematomas include laparotomy and hepatic artery embolization.Figure 1.: Coronal section of MRI with IV contrast (Liver mass protocol) of abdomen and pelvis demonstrates subcapsular hepatic hematoma involving the hepatic dome and right hepatic lobe approximately measuring 24 cm in craniocaudal dimension.

Giant Hepatic Subcapsular Hematoma after Endoscopic Retrograde Cholangiopancreatography (ERCP): A Case Report

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most commonly performed minimally invasive procedures for the diagnosis and treatment of biliary and pancreatic diseases. Hepatic hematoma secondary to ERCP is a rare and potentially serious complication with few cases described in the literature. Objective: The objective is to present a case of a giant hepatic subcapsular hematoma (HSH) secondary to ERCP, surgically resolved by laparotomy due to its recurrence and significant growth. Case report: We present the case of a 55-year-old female patient with a history of laparoscopic cholecystectomy and subsequent ERCP due to residual choledocholithiasis. The patient presented intense abdominal pain and fever after being discharged home, so she was admitted to the general surgery service where a HSH was diagnosed. Initially, conservative treatment with imaging follow-up is indicated, however, due to growth of the hematoma and recurrence, surgical treatment is indicated. Conclusion: Most patients respond to conservative treatment, however there will be patients who require surgical treatment, so suspecting this pathology will help provide timely treatment.

Endoscopic Retrograde Cholangiography-Induced Subcapsular Hepatic Hematoma

Endoscopic retrograde cholangiography (ERC)-induced subcapsular hepatic hematoma is a rare but potentially fatal complication. Right hypochondrial pain is the most common symptom and diagnosis is based on imaging after procedure. Majority can be managed successfully with conservative measures. Angioembolization and surgery may be required in hemodynamically unstable patients. We report a case of ERC-induced subcapsular hepatic hematoma detected laparoscopically following endoscopic stone extraction and managed conservatively.

Hepatic subcapsular hematoma post-endoscopic retrograde cholangiopancreatography requiring embolization.

Endoscopic retrograde cholangiopancreatography (ERCP) placement of biliary stents is the procedure of choice for bile duct strictures. Complications of endoscopic retrograde cholangiopancreatography have a low incidence. Hepatic subcapsular hematoma is uncommon but potentially serious. It is caused by laceration of the bile duct with guidewire or biliary traction during the procedure. Initial management is conservative with supportive measures. In case of hemodynamic instability or superinfection, embolization of the affected branch or even surgery could be performed.