Subacute Erythematosus Lupus Research Articles

Hydroa vacciniforme as a differential diagnosis of atopic dermatitis

Results Patient’s symptoms started at age 4, presenting with vesiculopapular eruptions and pruritus on photoexposed areas, evolving into crusts. She had been treated with anti-histamines and topical steroids for several years, with no improvement. Sometimes the patient referred other associated symptoms, including dizziness, dyspnea, chest pain and strong pain in the thighs. Additional treatments included oral corticosteroids, moisturizers, sunscreen filter factor 30 and cyclosporine. On physical exam, the patient presented erythematous papules, infiltrated, associated with lichenification, crusts and chafing on the surface of the exposed areas in the upper limbs, anterior chest, lumbar region and lower limbs, and erythematous plaques in the nasal and malar region. Differential diagnosis included Atopic Dermatitis, Besnier’s Prurigo, Idiopathic Prurigo, Subacute Erythematosus Lupus, Protoporphyria and Contact Dermatitis. At our hospital she underwent skin biopsy, and the results showed characteristic features of Hydroa vacciniforme. The patient now is being treated with chloroquine 250mg/day, Pimecrolimus cream twice daily on the face, mometasone once a week, hydroxyzine 25mg twice daily, and sunblock factor 30. She reports great improvement of symptoms.

Influence du tabagisme sur l'efficacité des antipaludéens de synthèse (APS) sur les lésions cutanées de sujets atteints de lupus : évaluation à travers une étude prospective

Purpose. – Smoking has been involved in the failure of antimalarial therapy in patient with chronic or subacute erythematosus lupus. Methods. – We report a prospective study of 26 patients with chronic, subacute or systemic erythematosus lupus who were treated with antimalarials. Several variables including smoking are compared in responders and non-responders. Results. – Despite the reduced number of patients study that does not permit to allow significative results, it seems that among responders and non-responders, in other respects comparables, there is no difference in the presence of smoking, its quantity or its duration. Conclusion. – The significance of molecular interactions between some components of tobacco and antimalarials have still to be established.