Diabetes mellitus is the metabolic illness, if it is left untreated it leads to secondary complications especially in patients suffering from T2DM. Herbal drugs are in medical use since ages. It is found that both Adathoda vasica and Andrographis paniculata exhibited anti-diabetic activity. Therefore, this study is aimed to explore their therapeutic effects in alleviating the secondary complications like neuropathy, cardiopathy using HFD-low dose STZ experimental model. Present study is designed to explore the therapeutic potential of an aqueous ethanolic extract of Adathoda vasica and Andrographis paniculata in alleviating diabetic cardiopathy and neuropathy against HFD-low dose of STZ induced diabetic model. Diabetes was induced by treating the animals with HFD-low dose of STZ injection. Diabetic animals were selected for further investigation on cardiopathy and neuropathy where untreated and treated (Pioglitazone, increasing doses of AEEAV, AEEAP) diabetic animals were subjected to Eddy’s hot plate test, Tail immersion test and Charcoal meal test. Oxidative parameters (MDA, GSH, SOD, CAT) were measured from sciatic nerve and heart homogenate, serum CK-MB, LDH, TC, TG, LDL and HDL were also measured. AEEAP showed improvement in intestinal transit time (P<0.001), restored antioxidants and reduced MDA levels in comparison with untreated diabetic animals (P<0.001). Cardiac biomarkers like CK-MB, LDH, TC, TG, LDL were significantly reduced in dose dependent manner (P<0.001) whereas HDL was found to be increased in treated diabetic animals. In addition, histopathology studies were well co-related with bio chemical improvement. Therefore, aqueous ethanolic extract of Adathoda vasica and Andrographis paniculata alleviates diabetic cardiopathy and neuropathy in HFD- STZ model of diabetes.