The study of shock wave propagation in a detonation chamber is of great importance as a part of the plate forming process. Investigations related to the effects of premixed gas detonation on the deflection of a plate require in-depth examination. An Eulerian-Lagrangian numerical simulation is conducted using the space-time conservation element and solution element method of LS-DYNA software to study the effect of confined multi-point ignited gaseous mixture on the dynamic response of thin plates clamped at the end of a combustion chamber. The FSI couples a Lagrangian finite element solver with a Eulerian fluid solver in a 2D space with detailed chemistry of H2–O2 mixture. The solution contains the detonation wave propagation through the combustion chamber and its interaction with the plate. The influence of variation in the multi-point ignition locations and combustion chamber dimensions on the pressure history and plate deflection is studied. To verify the model, a comparison with the experimental study is carried out using an adjustable model representative of the real experiment. The verified model is used to link the evolution of plate shape with the arrival time and intensity of shock waves within the chamber. It is found that a longer distance between the ignition point and the plate intensifies the ultimate deflection of the plate. In addition, a fairly large combustion area employed in a direction rather than transverse to the plate surface is unable to influence the ultimate deformation of the plate.