Study Of Salivary Gland Tumors Research Articles

Salivary gland tumor incidence in adult patients in a tertiary hospital in Mexico from 2008 to 2019.

To determine the incidence of salivary gland tumors in a population of a tertiary hospital in the State of Mexico, and to describe demographic variables. An observational, cross-sectional and retrospective study of salivary gland tumors reported in a tertiary hospital in the State of Mexico in the period 2008-2019 is presented. A prevalence of 0.049% was found. There was no difference between sex in the studied population. Benign salivary gland tumors were the most frequent (86.7%). The age range most affected was 51-60 years. The most frequently found tumor was the pleomorphic adenoma, followed by Warthin's tumor. There was 13.33% of sialolipomas, and one myoepithelioma. There were no cases of sublingual gland tumors or minor salivary glands. Tumors of the major salivary glands are infrequent tumors; population cases from a central Mexican state and their demographic characteristics are presented to contribute to the information found in local and international literature.

Clinicopathological Study of Salivary Gland Tumors in Tertiary Care Teaching Hospital

Background: The study “Preoperative predictors of ossicular status in chronic suppurative otitis media” was undertaken in Swami Rama Himalayan University, Dehradun. A total number of 124 patients who underwent “tympanomastoidcetomy” for CSOM were evaluated to correlate the preoperative predictors with intraoperative ossicular status. Materials and Methods: This study was carried out for 12 months period in the Department of Otorhinolaryngology at Himalayan Institute of Medical Sciences, SRHU, Swami Ram Nagar, Dehradun. Subjects were recruited from Inpatient Department planned for surgery. Each of the patients selected for the study was subjected to a detailed history and complete ear, nose and throat examination. Site and size of perforation, status of attic, middle ear mucosa status, presence of myringosclerosis, tympanosclerosis, granulations and cholesteatoma were noted in each patient. Degree and type of hearing loss was evaluated via pure tone audiometry. Results: Most of the patients belonged to the age group of less than 40 years, with maximum patients falling in the age group of 21-30 years i.e.,39 (31.45%) patients. The average age of patients was 29.39±10.79 years. Female predominance was seen with male to female ratio being 1:1.33. More cases were from rural areas comprising of 81 (65.3%) cases while 43 (34.6%) resided in urban areas. Ear discharge was the most common presenting complaint seen in 109 cases (87.90%) followed by hearing loss which was present in 100 cases (80.64%). Unilateral ear discharge present in 89 (81.65%) and 20 (18.34%) had bilateral ear discharge. Conclusion: Blood-stained discharge was present in 40 (36.66%) patients out of which 28 (70%) patients had ossicular necrosis. On assessing the amount of ear discharge, highest number of patients had scanty discharge i.e., in 75 (68.80%), out of which 30 (40%) patients had ossicular necrosis. Mucopurulent discharge was seen in highest number of patients i.e., in 68 (62.38%) out of which 30 (44.1%) had ossicular necrosis. Associated symptoms of vertigo were present in 28 patients (22.5%) out of which 16 patients (57.1%) had ossicles necrosed. On findings of otoscopy and otoendoscopy, perforation in pars tensa was seen in 82 patients (66.12%) out of which ossicular necrosis was present in 14 patients (17%). Highest incidence of ossicular necrosis was seen in 4 (4.83%) patients who had perforation involving both pars tensa and pars flaccida.

Clinicopathological Study of Salivary Gland Tumors at Tertiary Care Centre

Clinicopathological Study of Salivary Gland Tumors at Tertiary Care Centre

Histopathological study of salivary gland tumors: a tertiary care hospital-based study

Histopathological study of salivary gland tumors: a tertiary care hospital-based study

Study of salivary gland tumors and its management outcome in tertiary care hospital in Chennai

Background: Salivary gland tumors can arise from either the major salivary glands (parotid, submandibular and sublingual) or the minor salivary glands which are located throughout the submucosa of the upper aerodigestive tract. They can show a striking range of morphological diversity between different tumor types and sometimes within an individual tumor mass. Aim of the study was to study the role of fine needle aspiration cytology (FNAC) in the diagnosis of salivary gland tumors.Methods: This study was conducted comprising 34 patients attending the department of general surgery at Rajiv Gandhi government general hospital, MMC from January 2019 to December 2020 period of 24 months. A standard protocol was followed consisting of detailed history and physical examination, radiological evaluation followed by fine needle cytological examination. Histopathological examination was done in all the excised tumors for final diagnosis.Results: FNAC was done only in 20 out of 29 parotid tumors of which 12 were benign, 5 were malignant and 3 were inconclusive. In the present study superficial parotidectomy was done in 24 cases. Total parotidectomy was done in 3 out of 5 cases. Two patients refused surgery. Following surgery, 5 patients developed transient facial nerve paralysis and one patient developed permanent facial nerve paralysisConclusions: In tumors of the parotid gland, post-operative facial nerve palsy was rarely noticed. The best means of reducing iatrogenic facial nerve injury in parotid surgery remains an understanding of the anatomy coupled with a gentle technique.

Histopathological study of salivary gland tumours in a tertiary care hospital

Background: Salivary gland tumours constitute 3-10% of head and neck neoplasms. Their varied morphology poses challenge to pathologists as well as clinicians. Methods: The present observational study included 99 cases of salivary gland tumours. Clinical details and findings of histopathological examination were noted. Results: Mean age of the study subjects was 34.7 years. Female preponderance was seen. Most common site involved was parotid (64.7%). Most common tumour encountered was pleomorphic adenoma (76.5%). Malignant changes were seen in 17.6% cases. Most common malignant change seen was mucoepidermoid carcinoma (8.8%).Conclusion: Malignant changes were seen in 17.6% cases. Pleomorphic adenoma was the most common benign neoplasm and mucoepidermoid carcinoma was the most common malignant tumour seen.

Histomorphological spectrum of salivary gland tumors: a study at tertiary care teaching hospital of North Gujarat

Background: Salivary gland tumors (SGTs) are rare neoplasm of head and neck region. The salivary gland tumours vary widely in histopathological appearance. Also, epidemiological data of these tumors in various parts of the world are different. And so the study of SGTs for their biology and clinical characteristics can be helpful for a better understanding. Objectives: The objective of this study was to study types and new entities, common site of distribution and histomorphological spectrum of salivary gland tumors (SGTs). Materials and Methods: It was a retrospective followed by prospective study. Pertinent clinical history like age, duration of the lesion, site of the lesion, significant family and personal history, history of associated diseases was recorded. Specimens consisted of incisional biopsies were examined microscopically by the expert pathologist. Details of specimens noted in Performa include dimensions, appearance of external and cut surface and presence of lymph nodes, their size and number. Observations: Total 70 cases of SGTs could be included in the study. Among them 56 (80%) were benign and 14 (20%) were malignant. Parotid is commonest salivary gland involved with 75.71% of all tumors, followed by submandibular with 21.42% and minor salivary glands with 1(1.4%) of salivary gland tumors. among benign tumors Pleomorphic adenoma is most common with 70% of all benign SGTs followed by Warthin tumors (7%). Among malignant tumors commonest is Mucoepidermoid carcinoma with 14.28% of all SGTs. Female preponderance was clearly found in malignan at SGTs. Conclusion: Parotid is most common site for the SGT. And pleomorphic adenoma and the Warthin tumors are the common benign tumors involve parotid gland the most. Among malignant tumors mucoepidermoid carcinoma are the commonest with female preponderance. While other carcinoma like adenoid cystic carcinoma and SCC are also common.

A demographic study of salivary gland tumors

Background: Salivary gland lesions, especially the neoplastic lesions constitute a highly heterogeneous histopathologic group. Several studies have reported a significant difference in the global distribution of salivary gland tumors, but no formal study has been carried out in this part of the globe. Objectives: The objectives were: (1) retrieval of salivary gland tumors from the files of Department of Oral Pathology and Microbiology, Government Dental College and Hospital (GDC and H), Nagpur, to analyze the relative frequency of individual salivary gland tumors and (2) to correlate the various salivary gland tumors according to age, sex, location, and duration and compare the findings of this study with studies conducted in other countries. Materials and Methods: This is a retrospective study of all salivary gland tumors retrieved from the files of Department of Oral Pathology and Microbiology, GDC and H, Nagpur. Data thus collected archives were analyzed. Results: Out of total 75 cases, 29 pleomorphic adenoma, 8 basal cell adenoma, 16 mucoepidermoid carcinoma, 5 adenoid cystic carcinoma, 4 acinic cell carcinoma, 4 adenocarcinoma, 2 polymorphous low-grade adenocarcinoma, and single case each of cyst-adenoma, basal cell adenocarcinoma, epimyoepithelial carcinoma, salivary duct carcinoma, carcinoma in ex-pleomorphic adenoma, malignant myoepithelioma, and mucinous adenocarcinomas were reported. These cases were analyzed considering the parameters such as age, sex, location, duration, radiographic findings, and histopathological appearances. These were compared with studies conducted in other parts of the world. Conclusion: In conclusion, the data and results presented herein were similar to previously published reports in other countries and other areas of India and globe. However, some differences were observed, these differences can be attributed to racial factors, the pathology centers of sample collection and the duration of the studies.

Immunohistochemical study of salivary gland tumors in a tertiary institution in South-South Region of Nigeria

Aim:The aim of this study was to see the usefulness of immunohistochemistry in diagnosing salivary gland tumors found in a tertiary health institution.Materials and Methods:Twenty-six formalin-fixed paraffin embedded salivary gland tumors were accessioned, and 2 μm were sectioned and processed using Streptavidin-Biotin immunoperoxidase method.Results:Adenoid cystic carcinoma (ADCC) was positive to alpha-smooth muscle actin (α-SMA) while mucoepidermoid carcinoma (MEC), polymorphous low-grade adenocarcinoma (PLGA), squamous cell carcinoma (SCC) and oncocytic carcinoma (OCC) were all negative to it. MEC, PLGA, ADCC and the only pleomorphic adenoma (PA) were positive to Ki-67 while both SCC and OCC were negative to it. All the tumors except PA were positive to p63.Conclusion:It appears that α-SMA may be used to distinguish ADCC from MEC and PLGA, but Ki-67 cannot be used for this purpose. Furthermore, p63 cannot help in the diagnosis of ADCC, MEC or PLGA. It was concluded that immunochemistry can be used as adjunct to routine H and E stain in the diagnosis of the various salivary gland tumors.

Clinicopathological study of Salivary Gland Tumors

Background: The tumors of the salivary glands are uncommon head and neck neoplasms. The aim of this study was to evaluate the relative frequencies, types, site distribution and the histopathological features of salivary gland tumors. Materials and Methods: This was a cross-sectional study of 50 patients of salivary gland tumors in the department of General Surgery in Victoria hospital attached to Bangalore Medical College and Research Institute, Bangalore . Tumors were analyzed based on demographics, anatomic location and histopathological type. Results: Out of 50 cases, 39 (78 %) were benign and 11 (22 %) were malignant with M:F ratio of 1.5:1. Highest incidence of tumors were found in 3 rd decade of life and next common age incidence have been noted in 2 nd decade. Male were more prone to develop both benign and malignant parotid tumor than that of female. Pleomorphic adenoma was found to be the commonest benign tumor (52 %). The mucoepidermoid carcinoma was the most common malignant tumor (10 %). Parotid was the most common site for the location of tumors (70%) followed by submandibular (26%) and sublingual salivary glands (4 %). Conclusion: Pleomorphic adenoma was the commonest salivary gland tumor observed in both sexes. Mucoepidermoid carcinoma was the most common malignant salivary gland tumor. The parotid gland was the most common site of origin in both benign and malignant tumors.

Salivary Gland Tumours at Komfo Anokye Teaching Hospital, Ghana

In African studies on salivary gland tumours, there are considerable epidemiological differences in different parts of the continent. There is no study of salivary gland tumours from the second largest hospital in Ghana, Komfo Anokye Teaching Hospital. Aim: This study was to look at the prevalence and demographic distribution of salivary gland tumours at the Komfo Anokye Teaching Hospital (KATH). Method: Histopathologically diagnosed salivary gland tumours of consecutive patients were evaluated. The study duration was from 1999 to 2010 October. Result: The total number of salivary gland tumours were 121. Male to female ratio was 1.75:1. Out of the total of 34 salivary malignancies seen, male to female ratio was 1.8:1. Malignant tumour was 28.1% while 71.9% were benign. Mean age for malignancy was 53.5 years (SD = 9.7) and that for benign was 35.5 years (SD = 8.2). Conclusion: The commonest benign tumour of the parotid was Pleomorphic adenoma (48.3%) which is consistent with most of the African and western reports. Warthin’s tumour prevalence was higher than most of the studies from Africa.

Tissue microarray construction for salivary gland tumors study

Objective: To describe and discuss the design, building and usefulness of tissue microarray (TMA) blocks for the study of salivary gland tumors (SGTs). Study Design: Two hundred thirty-eight formalin-fixed, paraffin-embedded SGTs were arranged in blocks of TMA using a manual tissue arrayer. Three representative cores of 1.0, 2.0 or 3.0mm were taken from each original block and their characteristics were analyzed and described. Results: It was created 12 TMA blocks that presented highly representative neoplastic cylinders. However, those neoplasias rich in cystic spaces such as mucoepidermoid carcinoma and Warthin tumor presented more difficulties to be sampled, as the neoplastic tissue available was scarce. Tissue damage and loss during TMA construction was estimated as 3.7%. Conclusion: Representative areas of SGTs, with relatively small loss of tissue, can be obtained with the construction of TMA blocks for molecular studies. However, tumors rich in cystic spaces present more difficulties to be adequately sampled. Key words:Tissue microarray, tma, salivary gland tumors, immunohistochemistry.

Salivary gland tumours: 25 years of experience from a single institution in Croatia

IntroductionThe aim of this study was to determine the types, frequency, distribution, and demographic characteristics of salivary gland tumours in a large representative sample. Patients and methodsWe retrospectively analysed the medical records of 779 patients with tumours of the salivary glands surgically treated from 1985 to 2009 at a single institution. ResultsThere were 500 benign and 279 malignant tumours. The average age of patients with benign tumours was 50 years and of malignant salivary gland tumours 56 years. No differences in age and incidence of tumours existed between males and females. The majority of the tumours occurred in the parotid gland (509), followed by the minor salivary glands (212), the submandibular gland (51) and lastly, the sublingual gland (7). Minor salivary gland tumours occurred most frequently on the palate, the pleomorphic adenoma being the most frequent benign tumour type and the adenoid cystic carcinoma being the commonest malignant tumour. Tumours of the sublingual gland were rare, but all were malignant. Malignant tumours were more common in the minor salivary glands and the submandibular gland. ConclusionThis large study of salivary gland tumours in Croatia could improve our understanding of the significant differences in the global distribution of salivary gland tumours which have been reported.

Clinicopathological study of salivary gland tumors: an assessment of 303 patients

Salivary gland neoplasms are remarkable for their histological diversity and several studies point to their varied occurrence in the population. Clinical aspects were histologically assessed to determine possible associations and define parameters to differentiate benign and malignant neoplasms. The case files of patients diagnosed with epithelial salivary gland tumors between 1989 and 2005 were reviewed. A majority (71%) of the 303 salivary gland tumors studied were benign and pleomorphic adenoma were found to be most common. Mean ages for patients with benign and malignant tumors were 49.2 and 58.5 years, respectively. A statistically significant difference between these tumors was observed for the following variables: mean age, tumor size and disease duration. A correlation was found between histological diagnosis and tumor consistency. The data presented here corroborate a number of previous studies and are therefore relevant in understanding the diverse characteristics exhibited by these tumors.

Histopathological study of salivary gland tumours in Ile-Ife, Nigeria

The objective of this study is to document the prevalence and clinicopathologic features/pattern of salivary gland tumours in Ile-Ife, southwestern Nigeria. Fifty eight (58) cases of salivary gland tumours histologically diagnosed between January 1989 and December 2007 were identified from the biopsy records of the Departments of Morbid Anatomy and Forensic Medicine and Oral/Maxillofacial Pathology of the Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria. The records of the patients were extracted and data on incidence, age, gender and site of the various tumours were analysed using descriptive statistics. Pleomorphic adenoma was the most common salivary gland tumour reported accounting for twenty-five (43.1%), followed by Mucoepidermoid carcinoma (eight, 13.8%). Adenoid cystic carcinoma and myoepithelioma each accounted for six cases (10.3%). Non-Hodgkin's lymphoma of the salivary gland occurred in two patients. Twenty-six (44.8%) cases occurred in males while thirty-two (55.2%) occurred in females giving a male-to-female ratio of 1:1.2. The parotid region was the most common site accounting for twenty-eight (49.1%) cases, followed by the submandibular region 16 (28.1%) and palate 10(17.5%). Pleomorphic adenoma is the most common salivary gland tumour. Contrary to other African studies, our series reveals mucoepidermoid carcinoma as the commonest malignant salivary gland tumour.

A histopathologic study of salivary gland tumors in Kano, northern Nigeria

Significant differences in the global distribution of salivary gland tumors have been reported, but no formal study has been carried out here in Kano, the largest city in northern Nigeria. We therefore undertook this eight-year retrospective study of all histologically diagnosed salivary neoplasms at the histopathology laboratory of our referral teaching hospital in Kano. Seventy-eight salivary gland tumors were diagnosed during the eight-year study period accounting for 0.4% of all neoplasms. Benign tumors were more prevalent, comprising 56.4%, while malignancies were 43.6%. Pleomorphic adenoma and mucoepidermoid carcinoma were the commonest histological types constituting 48.7% and 23.1% respectively, while the most frequent sites were parotid, submandibular and minor salivary glands accounting for 49%, 26% and 24% respectively. As in most studies of black populations there were no adenolymphomas. Age distribution was bimodal with a benign peak in the third decade and a malignant peak in the sixth. Our findings were broadly similar to most other African reports but somewhat at variance with Western literature. Improved hospital attendance with more comprehensive reporting would yield more representative data.

Sonographic Features of Salivary Gland Tumours

Objective: High resolution ultrasonography (US) has played a significant role in the study of salivary gland (SG) pathology and has surpassed sialography in the study of SG tumours. This report discusses the sonographic features of SG tumours examined during the last 5 years. The value of these features as diagnostic indicators of the nature (benign or malignant) and histotype of these tumours is assessed. Methods: High resolution ultrasonography was used in the study of 83 cases of salivary tumours, 78 of which were of the parotid gland and 5 of the submandibular gland. Sixty-six (80%) of these tumours were benign. An US scanner with a 7.5-MHz real-time linear probe was used. The diseased SG was examined in multiple planes to fully delineate and locate the lesions and to characterize their sonographic features. Results: US detected and correctly located all tumours. The sonographic features of the various tumour categories studied are presented with special emphasis on diagnostically significant ones. The value of these features as diagnostic indicators of the nature (benign or malignant) and the histotype of these tumours is assessed. In this study, the rate of correct US identification of tumour benignity was 100% in a group of 15 adenolymphomas and 12 benign non-epithelial tumours, and 94% in a group of 34 pleomorphic adenomas. Five cases of recurrent pleomorphic adenoma were also studied. Correct US identification of malignancy was achieved in 82% of malignant tumours (15 carcinomas and 2 isolated primary non-Hodgkin’s lymphomas of the parotid gland). US identification of the specific tumour histotype was quite successful in the case of benign tumours with an accuracy of 84% in pleomorphic adenoma, 93% in adenolymphoma, and 100% in vascular tumours and lipoma. Only 1 of the 17 malignant tumours (a carcinomatous pleomorphic adenoma) was specifically identified. Conclusion: Based on the diagnostic capabilities of US revealed in this study as well as its operational advantages, US is strongly recommended as the first-line imaging procedure for all masses at the SG regions, to be followed by US-guided fine needle aspiration biopsy particularly for equivocal cases.

A retrospective study of salivary gland tumors. 143 cases treated during a 27-year period

A retrospective study of salivary gland tumors. 143 cases treated during a 27-year period

ABO blood groups and salivary gland tumors (Alabama, United States)

Studies of associations between various diseases and the ABO blood groups have shown elevated relative risks for some categories of disease. A strong association between salivary gland tumors and blood group A has been reported, but studies are few and have yielded contradictory results. To investigate this association, we conducted an epidemiologic study of salivary gland tumors diagnosed in Jefferson Country, Alabama (United States), 1968-89. All tumors were histologically confirmed. Blood group information was obtained for 200 individuals with salivary gland tumors, and the distribution of ABO and Rh blood type for cases was compared with that of 52,118 healthy blood donors from the same geographic area. The 38.5 percent of salivary gland tumors in cases with blood group A was similar to the 39.0 percent observed for controls (P = 0.95). No differences were observed when benign and malignant tumors were considered separately, nor for any of the major histologic types of tumor. The distribution of Rh factor among cases and controls also did not differ significantly (P = 0.08).

Lung Cancer Risks: Comparing Radiation with Tobacco

In a recent article on the incidence of salivary gland tumors among A-bomb survivors, Land et al. reported significant increases in risk with increasing A-bomb dose avd found that most of the dose response was produced by malignant mucoepidermoid tumors and benign Warthin's tumors (1). With respect to these two histologies, we reanalyzed case-control data from a Los Angeles County study of tumors of the parotid gland (about 80% of salivary gland tumors arise in the parotid glands) diagnosed between 1976 and 1984 (2), the largest study of salivary gland tumors to date, designed to assess the risk of medical and dental radiography. Radiation treatment to the head or neck at least 5 years prior to diagnosis was used as a simple dichotomous exposure with which to test the histologyspecific hypothesis. Risk was highest but was not limited to malignant mucoepidermoid tumors (Table I); none of the benign tumors were Warthin's tumor. Thus our data provide limited support for the conclusions of the A-bomb survivor study of salivary gland tumors and radiation risk. TABLE I