Study Of Events Research Articles

A real-world pharmacovigilance study of FDA adverse event reporting system events for Lutetium-177-PSMA-617

A real-world pharmacovigilance study of FDA adverse event reporting system events for Lutetium-177-PSMA-617

Cardiovascular adverse events associated with triptans for treatment of migraine: a pharmacovigilance study of the FDA adverse event reporting system (FAERS).

The purpose of this study was to determine the relationship between triptans (sumatriptan, rizatriptan, and zolmitriptan) and cardiovascular (CV) adverse events with data from the FDA Adverse Event Reporting System (FAERS). FAERS database was used to collect data on triptans from 1997 to 2023. Disproportionality methods were utilized to quantify triptan-associated CV events and to identify the potential risk. The reporting odds ratio was used to identify the risk signals. CV outcomes related to age, sex, clinical results, and other factors were also examined for triptans; 820 reports involving the triptans were recognized as CV adverse events out of total of 12 699 reports that were gathered from on FAERS database. Women reported more CV adverse events with rizatriptan and zolmitriptan as compared to men. The CV adverse event risk was highest among individuals aged 18-64. Clinical outcome analysis showed that sumatriptan carries a higher CV risk than rizatriptan and zolmitriptan, and most deaths and serious cases have been documented for sumatriptan. The patients prescribed sumatriptan or zolmitriptan were at a higher risk of reporting CV events for chest pain and chest discomfort, compared to rizatriptan. This finding may provide support for the clinical observation and risk evaluation of triptan treatment.

Real-world pharmacovigilance study of FDA adverse event reporting system events for finerenone

ABSTRACT Objective This study analyzed the signal mining of adverse events caused by finerenone based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) and evaluated the drug’s safety to provide a reference for the safe administration of this medication in medical institutions. Methods FAERS data from the third quarter of 2021 to the fourth quarter of 2023 were used, and the adverse event codes of the Medical Dictionary for Regulatory Activities were compared. After the data were processed, adverse event reports that featured finerenone as the most suspected drug were extracted. Results A total of 905 reported cases of adverse events including finerenone as the first suspected drug were extracted. The ratio of male to female patients was 1.25, and most were aged 65–85 years (30.1%). The adverse events that were reported more frequently with positive signals were decreased glomerular filtration rate, hyperkalemia, increased blood creatinine, and dizziness. The adverse events that were concentrated on in investigations were metabolism and nutrition disorders and diseases of the renal and urinary system. Conclusions Our study identified significant novel adverse events (AEs) signals for finerenone that could provide support for clinical monitoring of and risk identification for finerenone.

An extreme precipitation event over Dronning Maud Land, East Antarctica - A case study of an atmospheric river event using the Polar WRF Model

Extreme precipitation events (EPEs) are crucial in Antarctica, impacting the Antarctic ice sheet's surface mass balance and stability. Comprehensive case studies are essential for better understanding these events and the underlying processes driving them. Here, we investigate an extreme snowfall event in Dronning Maud Land (DML), East Antarctica on November 8 and 9, 2015. This event contributed approximately 22 % of the annual accumulation in less than two days and exhibited high spatial variability in precipitation distribution. We employed a high-resolution atmospheric model specifically optimized for the polar regions (Polar WRF) and ERA5 reanalysis data to analyze the event in detail. Our findings highlight the importance of a blocking high-pressure ridge of record strength that effectively blocked and diverted a strong extratropical cyclone into DML, ultimately leading to the heavy snowfall event. The sudden deepening of the cyclone was initiated by a ‘jet streak’ in the upper atmosphere that steered the system southeastwards towards the Antarctic coast. Notably, we observed an anomalously high poleward moisture transport in the form of a strong atmospheric river on November 7, 2015. This atmospheric river originated in the South Atlantic Ocean and tracked poleward from the 30°S-40°S latitude band. Vertical cross-sections of the model outputs indicate that most of the precipitation was concentrated in regions with steep orography along the path of the atmospheric river. This interaction between the atmospheric river and the steep terrain led to the uplift of maritime air, resulting in heavy snowfall. This study highlights the significance of extreme upper and lower atmospheric conditions in driving intense moisture transport towards coastal DML. The interaction between the atmospheric river and the steep orography contributed to heavy snowfall, underscoring the importance of considering orographic influences in understanding EPEs in Antarctica.

Expo2020 Dubai and Tourism Marketing: An Online User-Generated Content Analysis

Dubai is currently one of the world’s leading cities in the tourism field. Expo2020 has placed it in a remarkable position in sustainable tourism development amongst other tourist destinations. Information communication technologies (ICTs) have become essential for connecting tourism destinations with their visitors and other market partners. X (Twitter) facilitates online communication; embracing it have proved to be critical for boosting the brand image and reputation of tourism spots and augmenting their competitive advantage in the market. User-generated content (UGC) and electronic word of mouth (eWOM) have become important key players in this field. The purpose of this research was to deepen the study of the Expo2020 event in relation to tourism within the framework of ICTs. To do so, 3811 tweets posted from April 2021 to March 2022 using the hashtags #expo2020 and #visitdubai were analyzed. Users generated more than 10 tweets daily on this topic. Dubai’s institutional accounts were highly involved in creating content, leading personal accounts to follow the eWOM and UGC. Destination marketing organization (DMO) related to the Indian segment account stood out as one of the main players in the analyzed sample.

Safety assessment of Tafamidis: a real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events

ObjectiveTafamidis-associated adverse events (AEs) were investigated retrospectively by data mining the US Food and Drug Administration Adverse Event Reporting System (FAERS) to inform clinical safety.MethodsData were gathered from the FAERS database, which spans the second quarter of 2019 to the fourth quarter of 2023. A total number of 8532 reports of Tafamidis-related adverse events were detected after evaluating 8,432,351 data. Disproportionality analyses were used to quantify the signal and assess the significance of Tafamidis-associated AEs using four algorithms, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the multi-item gamma Poisson shrinker (MGPS) and the Bayesian confidence propagation neural network (BCPNN).ResultsAmong the 8532 reports of AEs with Tafamidis as the primary suspected drug, Tafamidis-induced AEs were identified as occurring in 27 system organ classes (SOC). A total of 207 Tafamidis-induced AEs were detected which simultaneously complied with the four algorithms. Our analysis also identified new adverse reactions including Hypoacusis, Deafness, and Essential hypertension. The median onset of adverse reactions associated with Tafamidis was 180 days (interquartile range [IQR] 51–419 days).ConclusionTafamidis is a drug that has shown favorable safety and tolerability results in clinical trials. However, a number of adverse reactions associated with Tafamidis have been identified through analysis of the FAERS database. In clinical applications, it is recommended to closely monitor patients’ hearing while using Tafamidis. In addition, it is hoped that further experimental and clinical studies will be conducted in the future to understand the mechanism of occurrence between Tafamidis and adverse reactions such as primary hypertension, hyperlipidemia, and height reduction.

Modeling Across Scales of Heavy Precipitation With a Global Variable‐Resolution Model: A Case Study of a Catastrophic Event in China

AbstractAn unprecedented heavy rainfall event in China (“21.7” extreme rainfall event) was simulated using the global variable‐resolution model (MPAS‐Atmosphere) across the scales (4, 8, 16 and 50 km). Although almost all experiments at different resolutions reproduce the spatiotemporal characteristics of precipitation, the simulated precipitation intensity from high to low is 16, 8, 50, and 4 km, with the 16 km simulation being closest to the observations. Precipitation magnitude is prominently influenced by the difference in simulated large‐scale circulation across a range of grid spacings. Further analysis revealed that the differences in latent heating across scales affect the geopotential height and wind field by altering temperature. The latent heating in 4 km simulation is the minimum while the 16 km simulation is maximum. More latent heating release leads to the low‐level pressure depression, amplifies the water vapor flux convergence, produces stronger upward motion and more clouds, and ultimately results in stronger precipitation. The sensitivity experiments for turning off latent heating tendencies during the event showed that the latent heat release has positive feedback on the “21.7” heavy rainfall event. This study highlights the importance of scale‐awareness of latent heat at different resolutions and suggests that the difference in simulated latent heat release during the event is the main reason for simulated different atmospheric circulation and precipitation across scales.

Pregnancy related adverse events and congenital disorders associated with fluoroquinolones: A real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS)

BackgroundFluoroquinolones, including ciprofloxacin, levofloxacin, and moxifloxacin, are extensively employed as broad-spectrum antibacterial agents. However, their use is discouraged during pregnancy due to potential adverse events (AEs). The aim of this study is to systematically investigate the association between fluoroquinolones (specifically ciprofloxacin, levofloxacin, and moxifloxacin) and AEs related to pregnancy, as well as their potential impact on congenital disorders. MethodsA disproportionality analysis was conducted utilizing FDA Adverse Event Reporting System (FAERS) data spanning from the first quarter of 2004 to September 2023. The objective was to identify potential AEs signatures associated with fluoroquinolones through conducting reporting odds ratios (RORs) and Bayesian confidence propagation neural networks (BCPNN). Assessing the potential risk of pregnancy-associated AEs involved comparing each fluoroquinolone with all other medications. Additionally, in-depth comparative analyses were carried out between various fluoroquinolones and a reference drug (azithromycin). ResultsA total of 1159 cases were identified, involving AEs related to pregnancy and congenital disorders. Obvious disproportionate association of abortion spontaneous and other nine AEs was identified for fluoroquinolone during gestation. Upon comparison with all the other drugs, ciprofloxacin exhibited an elevated risk of spontaneous abortion, non-site specific bone disorders congenital and 10 other significant signals. Levofloxacin demonstrated an increased risk of congenital tongue disorders and three other significant signals. Moxifloxacin displayed a noteworthy signal indicating multiple congenital cardiac abnormalities. ConclusionsWe present compelling evidence regarding pregnancy-related AEs and congenital disorders linked to fluoroquinolones. Considering perinatal and genotoxicity aspects, we explore whether levofloxacin or moxifloxacin might be preferable when fluoroquinolones are deemed necessary to balance the benefits of pregnant women and fetuses.

Catatonia related to tacrolimus: a real world pharmacovigilance study of FDA adverse event reporting system (FAERS) database

ABSTRACT Background Emerging case reports have highlighted that catatonia may be a complication that is easily misdiagnosed. Our study aimed to summarize the clinical characteristics of patients with tacrolimus-induced catatonia and assess the association between tacrolimus and catatonia through disproportionality analysis. Research design and methods We conducted a retrospective pharmacovigilance study using the FAERS database, analyzing data up to the third quarter of 2023. The clinical characteristics of the reported cases were summarized using descriptive statistics. Information component (IC) and reporting odds ratio (ROR) were used to evaluate the association between tacrolimus and catatonia. Results There were 66 reports of tacrolimus-related catatonia, with the majority of cases occurring in the United States (78.79%). The risk signal for tacrolimus-related catatonia was significantly higher compared to all other drugs (ROR 3.222 [2.524, 4.111], IC 1.632 [1.273, 1.991]). A significant association was detected in both male and female, while the risk signal of tacrolimus-associated catatonia was only found in the subgroups aged over 40 years. Conclusions Our study identified a safety signal for the association between tacrolimus and catatonia compared to all other drugs in FAERS database, particularly in patients aged 40 and above.

Landslide susceptibility mapping using physics-guided machine learning: a case study of a debris flow event in Colorado Front Range

Landslide susceptibility mapping using physics-guided machine learning: a case study of a debris flow event in Colorado Front Range

Central serous chorioretinopathy secondary to drugs: a real-world pharmacovigilance study of the FDA adverse event reporting system (FAERS)

ABSTRACT Background The objective of this study was to evaluate the reporting associations between Central serous chorioretinopathy (CSCR) and many available drugs using FAERS. Research design and methods FAERS reports from 2004 to 2023 were included in the study. The Medical Dictionary for Regulatory Activities (MedDRA) was used to identify CSCR cases. Reporting odds ratios (RORs) and corresponding 95% confidence intervals (CIs) for the reporting associations between available drugs and CSCR were calculated. A reporting association was considered statistically significant when the lower limit of the 95% CI was > 1.0. Results There were 1002 reports of 110 drugs with suspected drug-associated CSCR based on the ‘primary suspects’ role code in the FAERS database found to have statistically significant signals. Among the top 20 ROR drugs, the most frequently reported drugs were dermatological drugs (ATC:D, 210 cases, 64.41%), followed by antitumor agents and immunological agents (ATC:L,77 cases, 23.62%), Systemic Hormonal Preparations, Excl. Sex hormones and Insulins (ATC:H, 19 cases, 5.80%) and sensory organ drugs (ATC:S, 9 cases, 2.76%). The top 3 drugs associated with CSCR were Prednisolone (144 cases, 44.17%), Fluticasone (29 cases, 8.90%), and Methylprednisolone (27 cases, 8.28%). Conclusions This is the first real-world study using FAERS database to investigate drug-induced CSCR. Clinicians and pharmacist must keep in mind CSCR is a serious ocular complication associated with glucocorticoids, tyrosine kinase receptor inhibitor, and other drugs that can cause CSCR.

A real-world pharmacovigilance study of FDA adverse event reporting system (FAERS) events for sunitinib.

Sunitinib is approved for the treatment of metastatic renal cell carcinoma (mRCC), imatinib-resistant gastrointestinal stromal tumors (GIST), and advanced pancreatic neuroendocrine tumors (PNET). This study aims to investigate the safety profiles of sunitinib through data mining of the US Food and Drug Administration Adverse Event Reporting System (FAERS). The individual case safety reports (ICSRs) on sunitinib from 2006 Q1 to 2024 Q1 were collected from the ASCII data packages in the Food and Drug Administration Adverse Event Reporting System (FAERS). After standardizing the data, a variety of disproportionality analyses, including the reporting odds ratio (ROR), the proportional reporting ratio (PRR), the bayesian confidence propagation neural network (BCPNN), and the multi-item gamma Poisson shrinker (MGPS) were employed to identify the potential safety signals of sunitinib-associated AEs. A total of 35,923 ICSRs of sunitinib as the "primary suspected" drug were identified within the reporting period. The search detected 276 disproportionate preferred terms (PTs). The most common AEs, including diarrhea, asthenia, decreased appetite, hypertension, and dysgeusia, were consistent with the drug label and clinical trials. Unexpected significant AEs, such as uveal melanocytic proliferation, salivary gland fistula, yellow skin, eyelash discoloration, scrotal inflammation, were detected. The median onset time of sunitinib-related AEs was 57 days (interquartile range [IQR]16-170 days), with most of the ICSRs developing within the first month (n = 4,582, 39.73%) after sunitinib therapy as initiated. The results of our study were consistent with routine clinical observations, and some unexpected AEs signals were also identified for sunitinib, providing valuable evidence for the safe use of sunitinib in the real-world and contributing to the clinical monitoring and risk identification of sunitinib.

Risk of drug-induced angioedema: a pharmacovigilance study of FDA adverse event reporting system database.

The purpose of this study is to explore and analyze the FDA Adverse Event Reporting System (FAERS) database to identify drug adverse reaction signals associated with angioedema. The findings aim to provide valuable insights for clinical drug safety considerations. The Open Vigil 2.1 data platform was utilized to collect adverse event reports related to angioedema from the first quarter of 2004 to the fourth quarter of 2023. The reporting odds ratio (ROR) and proportional reporting ratio (PRR) were employed as disproportionality measures to detect adverse reaction signals Sof drugs associated with angioedema. A total of 38,921 reports were retrieved, with the majority being reported by healthcare professionals. The analysis included predominantly adult patients (≥18years of age), with slightly higher representation of females compared to males. Among the top 30 drugs associated with the occurrence of angioedema, 24 drugs showed positive signals in the risk analysis. Based on the individual drug reporting odds ratio (95% confidence interval) as a measure of risk signal strength, the top five drugs are as follows: lisinopril [ROR (95% CI): 46.43 (42.59-50.62)], enalapril [ROR (95% CI): 43.51 (39.88-47.46)], perindopril [ROR (95% CI): 31.17 (27.5-35.32)], alteplase [ROR (95% CI): 29.3 (26.95-31.85)], ramipril [ROR (95% CI): 20.93 (19.66-22.28)]. After categorizing the drugs, the strongest positive signal was observed in the antithrombotic agents [ROR (95% CI): 22.53 (21.16-23.99)], following that, cardiovascular drugs [ROR (95% CI): 9.17 (8.87-9.48)], antibiotics [ROR (95% CI): 6.42 (5.91-6.96)], immunosuppressors [ROR (95% CI): 5.95 (5.55-6.39)], anti-inflammatory analgesics [ROR (95% CI): 4.65 (4.45-4.86)], antiallergic drugs [ROR (95% CI): 4.47 (3.99-5)], antiasthmatics [ROR (95% CI): 2.49 (2.14-2.89)], blood sugar control drugs [ROR (95% CI): 1.65 (1.38-1.97)], and digestive system drugs [ROR (95% CI): 1.59 (1.45-1.74)] exhibited progressively decreasing ROR values. Many medications are associated with a high risk of angioedema. These medications play a crucial and potentially preventable role in controlling the occurrence of angioedema. It is essential to consider the risk level of drug-induced angioedema in clinical practice to optimize medication therapy.

A real-world pharmacovigilance study of FDA adverse event reporting system events for atogepant

ABSTRACT Background Atogepant, an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist, is being investigated for the treatment of migraine. Methods We collected data from the US Food and Drug Administration Adverse Event Reporting System (FAERS) database. Four algorithms (ROR, PRR, BCPNN, and EBGM) were used as measures to detect signals of atogepant-associated adverse events (AEs) in real-world data. Result Of the 3,552,072 reports, 2876 expressly stated the use of atogepant. Women accounted for the majority of adverse events (AEs), with a notable age concentration of 45–65 years. The percentage of reported adverse events was the highest in the United States. Significant system organ categories (SOC) included nervous system disorders, gastrointestinal disorders, nervous system disorders, surgical and medical procedures, ear and labyrinth disorders. Notably, preferred terms (PTs) related to atogepant include migraine, constipation, nausea, vertigo, somnolence, decreased appetite, dizziness and fatigue. Unexpected adverse events such as abnormal dreams, self-injurious ideation, brain fog, tension headache, nightmare, brain neoplasm, feeling abnormal, euphoric mood, hyperacusis and post concussion syndrome were also identified. Conclusions The present investigation has detected new and unexpected signals of atogepant-related adverse drug reactions (ADRs). In order to confirm these solve safety issues that were previously overlooked, more research is necessary.

Compartment syndrome associations with drugs: a pharmacovigilance study of the FDA adverse event reporting system (FAERS)

ABSTRACT Background Compartment syndrome is an uncommon but life-threatening condition. No study has comprehensively compared compartment syndrome (CS) association with available drugs. The objective of this study was to estimate the association between CS and drugs using the FDA Adverse Event Report System (FAERS). Research design and methods FAERS reports from the first quarter of 2004 to the third quarter of 2023 were analyzed. The Medical Dictionary for Regulatory Activities (MedDRA) was used to identify CS cases. Reporting odds ratio (ROR), corresponding to 95% confidence intervals (95% CI) were calculated to detect a positive signal. Results A total of 2197 reports were considered in the study after the inclusion criteria were applied. Totally 100 drugs were found to be associated with CS. The median time for drug-associated CS was 45 days. Conclusions By analyzing the FAERS database, the study revealed that certain drugs are significantly associated with compartment syndrome. Further studies are needed to verify whether these drugs are associated with such a risk.

Prestasi Akademik dan Perilaku Komunikasi Remaja Pengguna Game Online Free Fire (Studi Kasus di Desa Hijrah, Kecamatan Lape)

This research aims to determine the Academic Achievement and Communication Behavior of Adolescent Free Fire Online Game Users in Hijrah Village, Lape District. The research method used is qualitative descriptive with a research focus on case studies. This case study is a type of research that tries to understand a situation in depth and provide meaning. The type of case study used in this research is a situation analysis case study of a particular event or event. The data collection technique used is through documentation, in-depth interviews with informants to determine the Academic Achievement and Communication Behavior of Teenagers who use the Free Fire Online Game in Hijrah Village, Lape District. These findings provide valuable images and insights for parents, educators and researchers to understand more deeply about academic achievement and communication behavior.

Cultivating Hadhrami Memory: The Politics of Haul in a Malay-Speaking Hadhrami Sultanate in Indonesia

This article identifies haul, an annual commemoration of the death of charismatic figures, in Indonesia as political. The politicization of haul has been accompanied by a proliferation of narratives promoting the history of Hadhrami diaspora while strengthening the relationship between local Hadhramis and the local statesmen. This qualitative research examines the use of haul in Pontianak to commemorate selected syarif aristocrats. Pontianak, founded in the mid-eighteenth century by a syarif statesman, has a long-standing Hadhrami memory. Data for this study were collected through literature review, interviews, observation, and archival research related to Kadriah Sultanate’s haul events. The findings suggest that haul reshapes memories of the Kadriah Sultanate and Hadhrami identity for pragmatic purposes in local politics. By examining this case study of a commemorative religious event in the non-Arab world, it is shown that the local Arab sultanate redefines Hadhrami ethnic identity as nationalist, locally rooted, and heroic. Public haul festivals thus become effective tools for syarif politicians to exert influence in the religious and political spheres.

Do Satisfied Visitors Intend to Revisit a Large Sports Event? A Case Study of a Large Sports Event In Indonesia

Abstract Only a few studies on large sports tourism explore motorsport events such as the Moto Grand Prix. The present study addresses this gap by examining the factors influencing visitors’ satisfaction and intention to revisit related to the large sports event of MotoGP, Indonesia. The data were collected from visitors who had attended the MotoGP event in Indonesia using an online questionnaire with purposive sampling. The partial Least Square-Structural Equation Modeling (PLS-SEM) analysis was applied in this study to analyze the data. The findings indicate that hospitality, accessibility, and attraction significantly influenced visitor satisfaction at the MotoGP sports event in Mandalika, Indonesia. However, the factors of hospitality, infrastructure, accessibility, and attraction are insignificant where it concerns visitors’ intention to revisit. Moreover, satisfaction successfully influences visitors to revisit the MotoGP event in Indonesia. This study contributes to research on sports event management in large sports events by examining the factors that influence satisfaction and intention to revisit in the context of the MotoGP sports event, and contributes both theoretically and practically to research on sports events and tourism.

Plankton Community Changes and Nutrient Dynamics Associated with Blooms of the Pelagic Cyanobacterium Trichodesmium in the Gulf of Mexico and the Great Barrier Reef

Blooms of the harmful dinoflagellate Karenia brevis on the West Florida Shelf (WFS), Gulf of Mexico, are hypothesized to initiate in association with the colonial cyanobacterium Trichodesmium spp. and benefit from dissolved organic nitrogen (DON) release derived from N2-fixation by the cyanobacteria. Previous studies have detected DON release using direct experimental measurements, but there have been few studies that have followed nutrient release by in situ blooms of Trichodesmium and the associated plankton community. It was determined that long-term Trichodesmium spp. and Karenia brevis abundances on the WFS were related, following a 2-month lag. A separate Eulerian study of a Trichodesmium erythraeum bloom event was conducted over 9 days on the Great Barrier Reef. Concentrations of T. erythraeum increased over the course of the study, with coincident increases in dinoflagellate abundance and decreases in diatom abundance. Inside the bloom, concentrations of NH4+, PO43−, and DON increased significantly. The copepod grazer Macrosetella gracilis also increased in abundance as T. erythraeum numbers increased, contributing to nutrient release. Copepod grazing rates were measured, and N release rates estimated. Together, these studies show that Trichodesmium blooms have consequences for dinoflagellate abundance at both seasonal and ephemeral scales via direct and indirect N release.

Geological study of an outburst flood event in the upper Yangtze River and risk of similar extreme events

Outburst flood sediments are studied on the upper course of the Yangtze River (known as the Jinsha River) where is a key region for the development of hydroelectric power. As the history and magnitude of outburst flooding in this stretch of the Jinsha River during historic times has remained largely undocumented, we have endeavored as part of this study to conduct field investigations into, and provide numerical dating (using OSL and 14C dating techniques) of outburst flood evidence found in the First Bend area of the Yangtze River. Carbonized nutshells and charcoal from the ancient settlement yielded 14C ages that precisely pinpointed an outburst flood event ∼1200–1300 cal yr BP, during China's Tang Dynasty (618–907 CE). However, OSL ages using the minimum age model for all outburst flood samples ranged from 9.1 to 1.8 ka, which was ∼0.5–7.8 ka older than the 14C-dated outburst flood. This discrepancy suggests a potential overestimation of quartz age when dating outburst flood sediments from the Holocene period. Furthermore, using 2D hydraulic modeling, we estimated the magnitude of the aforementioned outburst flood, revealing a reconstructed peak flow discharge of 51,000–55,300 m3/s. This discharge was three times greater than the 10,000-year flood for the hydroelectric power station nearest to the study area. Our study underscores the significant role of combining archaeological and geological evidence in enhancing paleoflood hydrology research. Through a multidisciplinary approach, our findings emphasize the importance of paleoflood hydrology studies in comprehending both the latent and catastrophic flood risks in alpine mountain areas amid the context of global warming. Key points•A series of outburst flood sediments was identified in the First Bend area of the Yangtze River, with a maximum flood water surface ∼86 m high above modern river level.•The obtained 14C ages would suggest that the outburst flood occurred at ∼1200–1300 cal yr BP in the Tang Dynasty (618–907 CE) of China.•The reconstructed peak flow discharge (51,000–55,300 m3/s) is larger than the three times of the 10,000-yr flood for the nearest hydropower station to the study site.