Introduction. Sensory organs help humans exist in the surrounding world, but the evaluation of olfaction remained “in the shadows” practically until the COVID-19 pandemic, although many questions are still insufficiently studied, such as the effect of intranasal medications on olfactory function.Aim. To assess the olfactory function in healthy volunteers before and after a course of using an ectoine nasal solution.Materials and methods. Under our observation were healthy volunteers (medical university students and healthcare workers aged 16 to 35 years) who, in addition to routine ENT examinations, underwent an assessment of their olfactory status using a professional set of odorants for olfactometry and subjectively using a self-assessment scale for olfaction before and after a course of ectoine nasal solution, as well as a self-assessment of its preventive effect. The collected data were recorded in Excel spreadsheets (Microsoft Office 365) for further statistical analysis.Results and discussion. The results showed an average increase of 1 point in the self-assessment of olfaction in the observation group, as well as an increase in the number of “correct” responses when using the set of odorants. However, discrepancies were noted between self-assessment and the objective evaluation of olfaction. The extent of the preventive effect (based on the self-assessment by participants using a 10-point visual analog scale) was rated at 5 points.Conclusions. 1. A one-month course of barrier therapy (ectoine nasal solution) does not cause any impairment in olfactory function, as evidenced by olfactometric testing (an average increase of 10% in correct responses across the group, with 80% of participants showing improvement) and olfaction self-assessment (an average increase of 1 point across the group, with 55% of participants showing improvement). 2. Self-assessment of olfaction cannot be considered a reliable measure of the actual olfactory function. 3. The use of barrier therapy (ectoine nasal solution) has a moderate preventive effect (5 points).
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