Vomica Research Articles

Grilled nux vomica alleviates myasthenia gravis by inhibiting the JAK2/STAT3 signaling pathway: a study in a mice model

BackgroundGrilled Nux Vomica (GNV) is a promising traditional Chinese medicine to treat myasthenia gravis (MG), but its effects and mechanisms need further exploration.MethodsExperimental autoimmune MG (EAMG) model was established by muscle-specific kinase (MuSK) induction on C57BL/6 J mice. Mice were treated with GNV and/or ruxolitinib (JAK2 inhibitor) or AG490 (STAT3 inhibitor) for 30 days via gavage after modeling and randomized into 7 groups: control, model, low-dose GNV, middle-dose GNV, high-dose GNV, GNV + ruxolitinib, GNV + AG490. Body weight, muscle strength, clinical score, MuSK level, neuromuscular junction integrity (agrin and acetylcholine receptor [AChR] levels), inflammatory factors (IL-2 and IL-6), and the activation of the JAK2/STAT3 pathway were measured and compared between groups.ResultsGNV significantly improved body weight and muscle strength, as well as reduced clinical scores, MuSK levels, and inflammatory markers (IL-2 and IL-6) levels compared with untreated EAMG mice. GNV also protected the neuromuscular junction and increased agrin and AChR co-expression in a dose-dependent manner. In addition, GNV attenuated the levels of p-JAK2 and p-STAT3, which are aberrantly upregulated in EAMG mice. After co-treatment with ruxolitinib or AG490, the effect of GNV on body weight, muscle strength, clinical score, MuSK level, neuromuscular junction integrity, levels of inflammatory factors, and JAK2/STAT3 pathway was further amplified in EAMG mice.ConclusionsGNV improves MG by inhibiting the JAK2/STAT3 pathway, which might be an effective therapeutic strategy for MG.

Efficacy of Homoeopathic Medicine in Treating Gastritis: A Retrospective Case Series Study

Background:Gastritis is one of the commonest disease which affects all ages and sex. The prevalence rate also increases with the change in lifestyle. Aim: To analyse the effectiveness of homoeopathic medicine in treating gastritis. Methodology: Cases diagnosed to have gastritis visited OPD and IPD of Sarada Krishna Homoeopathic Medical College were considered in the study. Sample size selected was 40. Cases were selected based on inclusion and exclusion criteria. Pre structured case records of Sarada Krishna Homoeopathic Medical College were used in the study. Details were collected about age, sex, occupation, medicine selected and potency used. Follow up is added to assess the improvement of the patient. Result: Out of 44 patients, 23 were females and 17 were males. Majority comes between 48 and 58 years. 10 patients comes between 37 and 47 years,7 between 59 and 69 years. 5 each is seen between 15 to 25 years and 26 to 36 years and 2 patients are there between 70 and 80 years. 9 patients were treated with Lycopodium , 6 patients with Nux vomica, pulsatilla and sulphur has been used in 5 patients.3 patients were treated with silicea and 2 patients with cundurango., the other medicines used were Ignatia, Anacardium, Argentum nitricum,Calcarea Carbonicum, Sepia, Thuja, Arsenicum album, Bryonia, Ferrum Metallicum, Chelidonium. Most commonly used potencies is 200 by 23 patients.8 patients were treated with LM potency. 7 patients has taken 30 potency.1M potency was used in 2 patients. Conclusion: Homoeopathy has a better scope in treating such cases as long term use of modern medicine has shown an adverse effect in the health of patients.

Qualitative analysis of licorice and strychnine decoction before and after combination using UPLC-QE-Orbitrap-MS.

Glycyrrhiza glabra L. (GG) and Strychnos nux-vomica L. (NV) are traditional Chinese medicines (TCMs). Changes in the chemical composition may occur before and after the GG-NV compatibility. Ultra-performance liquid chromatography Q-exactive Orbitrap mass spectrometry (UPLC-QE-Orbitrap-MS) was applied here to study the difference in the components of the GG and NV decoctions before and after they were combined. The changes in the chemical composition of GG and NV before and after the combination were determined. The precise molecular weight, retention time, and fragment ion peak of the different components of the decoctions before and after compatibility were obtained through UPLC-QE-Orbitrap-MS. Differential analysis methods, such as principal component analysis, were used for comparison. In the positive ion mode, 200 new components were added, whereas six components were lost. In the negative ion mode, 144 new compounds were identified, whereas three components were missing. The compatibility difference between GG and NV was studied through UPLC-QE-Orbitrap-MS. The chemical composition of GG and NV changed before and after compatibility, and a class of compounds different from GG and NV was identified in the co-decoction. This study provides an experimental basis for subsequent research into detoxification mechanisms of the GG-NV combination and offers a new analytical method for investigating the compatibility of various other TCM pairs.

Estimation of the Likelihood Ratio of Different Symptoms for Six Homeopathic Medicines: Prognostic Factor Research.

Arsenicum album, Causticum, Nux vomica, Pulsatilla nigricans, Rhus toxicodendron and Sulphur are frequently prescribed homeopathic medicines; however, their symptoms, as mentioned in different homeopathic literature works, have rarely been investigated systematically. Likelihood ratio (LR), based on Bayesian statistics, may reflect a better estimation of the strengths of symptoms than the existing entries in the homeopathic literature. A prospective, longitudinal, analytical patient outcome study was conducted in the outpatient departments of D. N. De Homeopathic Medical College and Hospital, Kolkata, on 1,954 patients over 21 months. The outcomes were recorded at each follow-up using the Outcome Related to Impact on Daily Living (ORIDL) +4 to -4 scale. The average period of treatment for each participant was 3 months. The LRs of four symptoms for each of the six selected medicines were calculated. One hundred and two different remedies were prescribed. The prevalence, LR + , and LR - , with respective 95% confidence intervals, of different symptoms were reported. The study found that the following symptoms had particularly high LR+ scores: "intense sympathy for the suffering of others" (Causticum, LR+ = 12.0); "dyspepsia from business anxiety" (Nux vomica, LR+ = 27.4); "burning pain relieved by heat" (Arsenicum album, LR+ = 29.6); "envy" (Pulsatilla nigricans, LR+ = 13.2); "desire for milk" (Rhus toxicodendron, LR+ = 7.5); "very selfish, no regard for others" (Sulphur, LR+ = 20.6). The findings corroborated well with the presentation of the symptoms in different homeopathic materia medica and repertories. ORIDL scores of +2 or greater were identified most prominently for Pulsatilla nigricans (n = 138) and Sulphur (n = 119). There was adequate evidence to attribute all the assessed symptoms to the medicines investigated. Further studies with a larger population are warranted to tackle the possible confirmation bias.

An Atypical Case Report - Strychnos nux-vomica toxicity resulting from Vishtinduk Vati overdose linked with bradycardia

Strychnos nux-vomica, commonly known as poison nut, is a plant notorious for its toxic alkaloids, particularly strychnine and brucine. While cases of poisoning from nux-vomica ingestion have been documented, its occurrence following Vishtinduk Vati overdose is exceedingly rare. Here a case of a 55-year-old female with a known history of osteoarthritis who inadvertently overdosed on Vishtinduk Vati, an over-the-counter Ayurvedic medicine containing nux-vomica, in an attempt to alleviate her pain, led to severe poisoning characterized by classical symptoms of strychnine toxicity, including muscle twitching, vomiting and bradycardia, necessitating immediate medical intervention. This case highlights the dangers of self-medication with herbal remedies and the accessibility of potentially harmful over-the-counter Ayurvedic medications. It underscores the importance of healthcare providers opting for safer drug choices in daily practice and advocating against the indiscriminate use of herbal supplements, emphasizing the need for regulation and education to prevent such adverse outcomes.

Enhancing anti-inflammatory effect of brucine nanohydrogel using rosemary oil: a promising strategy for dermal delivery in arthritic inflammation.

Brucine (BRU), an active constituent of Strychnos nux-vomica L., is one of the potential agents to control subside swelling in arthritis. However, its hydrophobic nature, poor permeation, shorter half-life, narrow therapeutic window, and higher toxicity impede its clinical applications. Hence, this investigation was aimed to develop and evaluate novel BRU loaded β-cyclodextrin (β-CD) nanosponges (BRUNs) hydrogel consisting rosemary essential oil (RO), which have been tailored for delayed release, enhanced skin permeation, and reduced irritation, while retaining anti-oxidant and anti-inflammatory activities of this bioactive. Firstly, BRUNs were fabricated by melt technique and characterized appropriately. BRUNs6 demonstrated twofold enhancement in BRU solubility (441.692 ± 38.674) with minimum particle size (322.966 ± 54.456) having good PDI (0.571 ± 0.091) and zeta potential (-14.633 ± 6.357). In vitro release results demonstrated delayed release of BRU from BRUNs6 (67 ± 4.25%) over 24h through molecular diffusion mechanism. Further, preserved anti-inflammatory (53.343 ± 0.191%) and antioxidant potential (60.269 ± 0.073%) of bioactive was observed in BRUNs6. Hence, this Ns batch was engrossed with Carbopol®934 hydrogel with RO and characterized. In vitro (release and anti-inflammatory activity), ex-vivo (skin permeability) and in vivo (carrageenan-induced inflammation) assays along with irritation study were conducted for fabricated hydrogels. Results revealed that in vitro release of BRU was further delayed from Ns hydrogel with RO (56.45 ± 3.01%) following Fickian mechanism. Considerable enhancement in skin permeability (60.221 ± 0.322µg/cm2/h) and preservation of anti-inflammatory activity (94.736 ± 2.002%) was also observed in BRUNs6 hydrogel containing RO. The irritation of BRU was found reduced (half) after its entrapped in Ns. Further, as a proof of concept, BRUNs6 hydrogel with RO effectively reduced (75.757 ± 0.944%) carrageenan-induced inflammation in rat model in comparison to pure BRU (54.914 ± 1.081%). Hence, BRUNs hydrogel with RO can be considered as a promising alternative for dermal delivery of BRU in arthritis.

Healing of Haemorrhoidal Disease with Homoeopathy – A Case Series

AbstractHaemorrhoidal disease is recognised as one of the most common proctologic medical conditions in general population. This is a case series of five patients suffering from haemorrhoidal disease having intense pain while defecation, swelling around anus, bleeding per rectum, itching in anus and prolapsed internal haemorrhoids which were healed completely by the individualised homoeopathy without any surgical intervention. Haemorrhoidal disease symptom score and a disease-specific short health score were used to assess the symptom severity and improvement in quality of life of the patients, measured at baseline, third and at sixth month of the treatment. The possible causal attribution of the changes was assessed. The cases were reported according to the HOM-CASE guidelines. Homoeopathic medicines such as Acidum nitricum, Aesculus hippocastanum, Lycopodium clavatum, Nux vomica and Thuja occidentalis were found useful.

A novel nano-drug delivery system of glycyrrhetinic acid-mediated intracellular breakable brucine for enhanced anti-hepatitis B efficacy.

Background: Glycyrrhetinic acid-mediated brucine self-assembled nanomicelles enhance the anti-hepatitis B properties of brucine by improving its water solubility, short half-life, toxicity, and side effects. Brucine (B) is an indole alkaloid extracted from the seeds of Strychnos nux-vomica (Loganiaceae). Purpose: To assess the efficacy of the Brucine-Glycyrrhetnic acid-Polyethylene glycol-3,3'-dithiodipropionic acid-Glycerin monostearate (B-GPSG) in treating hepatitis B, its potential to protect against acute liver injury caused by d-galactosamine and its anti-hepatoma activities were studied. Research Design: The concentration of B-GPSG used in the in vivo and in vitro experiments was 0.63mg/mL. The rats injected with d-GalN (450mg/kg) were used as liver injury models. The rats were separated into normal, model, positive, positive control, B-PSG and B-GPSG groups. Hepatoma cells expressing HBV HepG2.2.15 were used for in vitro experiments. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, plate cloning, Hoechst staining and flow cytometry were conducted to explore the mechanism of B-GPSG against hepatitis B. Results: Compared with the model group, the liver coefficient of B-GPSG group decreased (4.59 ± 0.17 vs 5.88 ± 0.42), the content of MDA in rat liver homogenate decreased (12.54 ± 1.81 vs 23.05 ± 2.98), the activity of SOD increased, the activity of ALT and AST in rat serum decreased. In vitro, the IC50 values of B-GPSG group decreased. B-GPSG group effectively inhibited the proliferation and migration of HepG2.2.15 cells. Conclusions: The hepatoprotective effects of B-GPSG nanomicelles, which are attributed to their GA-mediated liver targeting and synergistic actions with brucine, suggest their therapeutic potential against hepatitis B. This development opens up new possibilities for the application of traditional Chinese medicine and nanomedicine in anti-hepatitis B.

Evaluation of a guideline for supportive anthroposophic therapies for hospitalised children with acute gastroenteritis – A prospective case series study

ObjectiveEven though several German children’s hospitals offer integrative, anthroposophic medical therapies in addition to the standard medical care, guidelines for these anthroposophic therapies are still rare. Therefore, we investigated the feasibility of implementing a published, consensus-based guideline for the treatment of children with acute gastroenteritis (aGE) with anthroposophic therapies in the community hospital Herdecke. DesignA prospective case series of paediatric patients (≤18 years) with an aGE admitted to the department of integrative paediatrics of the community hospital Herdecke was conducted. Demographic, clinical and therapeutic data was recorded at initial presentation and at follow-up visits. Physicians were surveyed with a questionnaire to evaluate feasibility of implementing the guideline. ResultsSixty-two patients (0–15 years; 22 male, 40 female) were included in the case series. All patients received some form of anthroposophic therapy. The most frequently used remedies were Geum urbanum, Nux vomica and Bolus alba comp. Treating physicians showed a high adherence to the expert-based consensus guideline in their prescribed therapies. All physicians stated that they were familiar with the guideline and used the recommendation to inform their therapy decision. Suitability for daily use and effectiveness in treating the main symptoms of aGE were highly scored by the physicians. ConclusionThe consensus-based guideline of anthroposophic therapies for aGE in children was successfully implemented and found to be useful for physicians in clinical practice.

Analysis of the Effect of Nux Vomica on Three Models of Chondrocyte Apoptosis

Analysis of the Effect of Nux Vomica on Three Models of Chondrocyte Apoptosis

Study on the pharmacological and toxicological mechanisms of Nux vomica

Study on the pharmacological and toxicological mechanisms of Nux vomica

Applying network pharmacology to homeopathic research: A case study of nux vomica for gastritis using TCMSP database

Applying network pharmacology to homeopathic research: A case study of nux vomica for gastritis using TCMSP database

Bacteriostatic effect of Coumarin 2-(3,4- Dihydroxyphenyl)-3,5,7-Trihydroxy-4H-Chromen-4-One Isolated from the root extract of Strychnos nux vomica.

Bacteriostatic effect of Coumarin 2-(3,4- Dihydroxyphenyl)-3,5,7-Trihydroxy-4H-Chromen-4-One Isolated from the root extract of Strychnos nux vomica.

Homeopathic Medicines in Third (Omicron) Wave of COVID-19: Prognostic Factor Research.

With the emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, such as the Omicron variant, during the third wave of the coronavirus disease 2019 (COVID-19) pandemic, there was a need to identify useful homeopathic medicines. This study aimed to identify such medicines and their indications using prognostic factor research (PFR). This was an open-label, multi-centred observational study conducted in January 2022, on confirmed COVID-19 cases. The data were collected from integrated COVID Care Centres in Delhi, India, where homeopathic medicines were prescribed along with conventional treatment. Only those cases that met a set of selection criteria were considered for analysis. The likelihood ratio (LR) was calculated for the frequently occurring symptoms of the frequently prescribed medicines. An LR of 1.3 or greater was considered meaningful. Out of the 362 COVID-19 cases, 263 cases were selected for analysis after applying selection criteria. Common symptoms included fatigue, cough, sore throat, myalgia and headache. Twenty-one medicines were prescribed, of which nine medicines - Gelsemium sempervirens, Bryonia alba, Hepar sulphuris, Rhus toxicodendron, Pulsatilla nigricans, Arsenicum album, Belladonna, Nux vomica and Phosphorus - were frequently used. By calculating LRs, the study identified meaningful indications for these medicines. Homeopathic medicines have shown promising results in the third wave of COVID-19 as an adjunct therapy. The medicines that were used in the first and second waves were found useful in the third wave also, and their indications were analogous to those found in the earlier waves. Certain new indications of some medicines were elicited in this wave, which warrant further research. However, it is important not to restrict to these medicines only and to continue data collection on COVID-19 in future waves for the improvement of the COVID-19 mini-repertory.

Morphology, Pharmacognosy of Strychnos nux-vomica and S. potatorum and their Medicinal Importance in Traditional Systems: A Review

The species Strychnos nux-vomica and Strychnos potatorum Linn., which belong to the Loganiaceae family, are used in traditional medicine to treat gonorrhoea, leukorrhea, gastropathy, bronchitis, chronic diarrhoea, dysentery, renal and vesicle calculi, diabetes, conjunctivitis, scleritis, ulcers, and other eye diseases. This medicinal species has been highlighted in an effort through pharmacological and phytochemical research. The morphology, phenology, distribution, phytochemical analysis, and pharmacological screening of Strychnos potatorum and nux-vomica, two significant medicinal plants, are the subjects of the current review. The gathered data may serve as the foundation for its widespread application as a therapeutic agent in both conventional and alternative medicine.

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma

The aim of the study was to investigated the mechanism of Strychnos nux-vomica L. (Semen Strychni, SS) against papillary carcinoma thyroid (PTC) by combined of network pharmacology and experimental verification. By searching the TCMSP, SEA and SwissTarget Prediction database, the main active ingredients and related targets were obtained. Utilizing Venny 2.1.0 String database and Cytoscape 3.7.2 to screened the intersection target and constructed protein–protein interaction (PPI) network diagram. Using R 4.0.4 software carried out the enrichment analysis of GO and KEGG. HPLC was carried out using LC-20A modular HPLC system to identify the bioactive compound brucine present in SS. Molecular docking was performed using Discovery 2019 software. The inhibition rate was detected by CCK8 method. Western blot was used to detect the expression levels of brucine anti-PTC related pathway proteins. 14 active components were screened out, of which 4 main components showed tight relationship with PTC. SS may play the anti-PTC role by acting on two main pathways (TNF signaling pathway and MAPK signaling pathway) and mediating various biological functions. HPLC analysis revealed that brucine was a suitable marker for standardization of the SS. 4 active components exhibit strong binding energy with core protein. Brucine could significantly reduce the activity of BCPAP cells compared with isobrucine, stigmasterol, (+)-catechin. Brucine may reduce the protein expression levels of IL-6, VEGFA, JUN, TP53, 1L1B, PTGS2, BCL2, CASP3, CASP8, and CASP9 while increase the protein expression levels of BAD, cleaved-CASP3, cleaved-CASP8, and cleaved-CASP9 in BCPAP cells, respectively. The active components of SS against PTC mainly include isobrucine, stigmasterol, (+)-catechin, brucine. Among them, brucine exhibits the strongest anti-PTC activity in BCPAP cells, which may reduce the PTC-related protein expression levels. Therefore, SS may exhibits the anti-PTC activities through multiple targets and pathways.

Standardisation of different extracts of detoxified Nux-vomica seeds with its comparative study by TLC and HPTLC

IntroductionDetoxified Nux-vomica (detoxified Strychnos nux-vomica Linn.) is a very popular crude herb used in Unani and Ayurvedic pathy after detoxification for many years. The first person to identify Nux-vomica with the Indian drug kuchla was Haji Zainuddin. Detoxified Nux-vomica has significant effects on various disorders like rheumatic arthritis, inflammation, and gout (Anonyms, 2007; Bentley and Trimen, 1983). It has proved the best remedy for paralysis, nervous disorders, nervous debility, tremor, diarrhoea, and mental emotions (Nadkarni, 2000). The present study is designed to develop the qualitative as well as quantitative parameters of crudely detoxified Nux-vomica seeds and their comparative study by Thin layer chromatography (TLC) and High-performance thin layer chromatography (HPTLC). MethodsOrganoleptic characters, ash values, extractive values, phytochemical analysis, fluorescence analysis, TLC and HPTLC profiles, etc. were the parameters used for the standardisation of the test drug. ResultsTotal ash values, water, alcohol, ether-soluble extractive values, and volatile oil percentages were found to be 1.925%, 6.54%, 3.25%, 3.20%, and 2.00%, respectively. The TLC profile of Detoxified Nux-vomica shows three spots for aqueous extract and five spots for hydroalcoholic extract in Toluene: Ethyl Acetate: Triethylamine (7:2:1) and four spots in Methanol: Ethyl Acetate: Triethylamine (0.5:8.5:1) with exposure in Dragendorff’s Reagent. The percentage yield of strychnine in the hydro-alcoholic and aqueous extracts of Detoxified Nux-vomica is 7.48 and 2.10, while it is 6.17 and 1.85 for brucine, respectively. ConclusionThe present study used secondary data for the identification and quantification of active constituents in detoxified Nux vomica seeds.

A Non-Randomized Single-Blind Clinical Study to Assess the Utility of Strychnos Nux-Vomica L. in the Management of Patients with Bowel Disorders

Purpose: Bowel disorders encompass a cluster of gastrointestinal conditions marked by persistent symptoms like abdominal discomfort, bloating, and changes in bowel patterns. They represent a significant public health concern necessitating increased awareness, diagnosis, and treatment efforts. This research sought to explore the potential of Nux Vomica as a treatment option for individuals suffering from bowel disorders, with the goal of reducing the frequency and intensity of their symptoms to provide optimal relief. Materials and Methods: This research involved 30 individuals diagnosed with bowel disorders according to the Rome IV diagnostic criteria. They received treatment with the homoeopathic remedy Nux Vomica, selected based on a comprehensive assessment of their symptoms. To assess the treatment's effectiveness, the study monitored a reduction in the number of symptoms and quantified improvements using the Gastrointestinal Quality of Life Index questionnaire. Results: Statistical analysis was carried out using the Student paired "t" test. Following the therapy, a significant reduction in the number of symptoms was observed, and no adverse effects were documented. On average, the GIQLI score exhibited an improvement of -38.23 ± 13.68 points (t-statistic value: 15.31), while the average decrease in the number of symptoms amounted to 4.03 ± 1.47 points (t-statistic value: 14.99). The resulting "p" value was 0.000, indicating an exceptionally low level of significance upon completion of the study. Conclusion: The homoeopathic remedy Nux Vomica effectively addresses bowel disorders. These results open up new avenues for future research exploring the treatment of bowel disorders with homeopathic medicine.

Homoeopathic Perspective in the Management of Substance Use Disorders: A Systematic Review

Background: Substance abuse has become a widespread global issue. It includes abuse of illegal substances, namely marijuana, heroin, cocaine and methamphetamines, and legal substances, including alcohol, nicotine or prescribed medicines.
 Aim of Review: This review assesses the role of Homoeopathy in the therapeutic management of substance use disorders (SUD) through a systematic web-based literature search.
 Methods: A comprehensive search was conducted online and manually to identify homoeopathic research studies published between 1993 and 2022 on SUD in international databases and the Central Council of Research in Homoeopathy library. Relevant studies were categorised and assessed in terms of study designs, number of participants, evidence grades and clinical outcome parameters. A total of 21 full-text studies were screened and evaluated. Risk of bias (RoB) was assessed for all studies and model validity was appraised for the included RCTs'.
 Results: 10 studies (3 Randomised Controlled Trials, 3 Observational studies, 1 Pilot study, 1 observational comparative study, 1 Retrospective cohort study and 1 case series) were included and 11 studies were excluded with reasons. 03 studies have a level of evidence of 1b with an 'A' grade of recommendation, which consists of the RCTs only. The most commonly prescribed medicines identified were: Arsenic album, Nux vomica, Lycopodium, Pulsatilla, Sulphur, Staphysagria, Belladonna, Ipecac, Chamomilla, Rhustox, Phosphorus and Lachesis.
 A high risk of bias was elicited in most of the observational studies accentuating the need for more robust methodological studies.
 Conclusion: The majority of the studies have a small number of recruitments. Pragmatic studies with larger sample sizes and validated outcome measures may be designed further to validate the promising role of homoeopathic medicines in SUDs and generate quality evidence.

A Comparative Clinical Study on Efficacy of Ahiphenmochanadi Vati and Sameeragaja Kesari Rasa in Opiate Withdrawal Symptoms

ABSTRACT Background: Ahiphen Vyasan (opium and its derivatives addicts) is a common addiction in Rajasthan, Punjab, and Haryana. The main symptoms of opiate withdrawal are Nadimandata (resting pulse rate), Swed Pravrutti (sweating), Arti (restlessness), Netratarak Vispharana (dialeted pupil size), Asthi or Sandhi Shoola (bone and joint pain), Nasasrava or Ashrusrava (running nose or tearing), Agnibaishamya (gastrointestinal upset), Kampa (Tramor), Jrimbha (Yawning), Vishada (feeling of unhappiness – depression), and Romanch (horripilation). Kuchla (Strychnos nux-vomica) has been mentioned as antidote for opium. Aim and Objective: The intention or aim here is to combat the opiate withdrawal effects by using opium in tapering method along with S. nux-vomica. For which the study refers to evaluate the efficacy of Ahiphenmochnadi Vati and Sameer Gaja Kesari Rasa in opium withdrawal symptoms. Material and Method: Open-labeled randomized clinical trial of thirty patients of either sex. Intervention: Group A (15 patients) was given Ahiphenmochnadi Vati, whereas Group B (15 patients) treated with Sameer Gaja Kesari Rasa. Duration: 1 month. Intragroup comparison of group A and Group B were found statistically extremely significant. Result: Intergroup comparison of Group A and B were found statistically significant. Conclusion: The present study supports the use of Ahiphenmochnadi Vati and Sameer Gaja Kesari Rasa in treating Ahiphen Vyasan with good acceptance by all treated patients.