This study deals with the changes in acoustic response caused by variations in the geometry and size of the sound holes in the Karadeniz kemenche, a bowed string musical instrument. Starting from a 3D scan of the instrument, a finite element model is built. The structural model is verified with the results of an experimental modal analysis study, followed by a model update procedure implemented by frequency optimization. The acoustic cavity is simplified to a rectangular geometry to analytically verify the acoustic cavity modes. Before analysing the variation of the sound holes, a verification of the structure-borne noise of the musical instrument is performed. The variation of acoustic response depending on the size and geometry of the sound holes are studied using the verified vibroacoustic model. The various geometries are inspired by shapes chosen for both ancestral and contemporary bowed string instruments. The normalized loudness levels attributed to each variation are computed and examined to see if a relationship could be found to evaluate the variations.