During recent years, aircraft manufacturers focused their attention on environmentally friendly and aerodynamically efficient aircraft concepts that could allow a radical reduction of emissions. The use of hybrid-electric powertrain is one of the most effective ways to design near-zero emission aircraft. These aircraft are highly performing and sophisticated. Hence, the design process must be extremely accurate and should make use of multidisciplinary design optimization. It is indeed crucial to establish both aerodynamic and structural models to simulate the aircraft performance and design required according to top level aircraft requirements. Despite the largely discussed literature about preliminary design of such an unconventional aircraft, there is still a lack of reliable weight estimation approaches, simulation-based mission analysis and optimization tools. In order to step towards higher technological readiness levels, the purpose of this paper is to describe and apply a design platform for conventional, turboelectric, hybrid-electric and full-electric aircraft, integrating aero-propulsive interactions, accurate power system modelling and medium-fidelity structural weight estimation. In particular, the comprehensive structural analysis of the aircraft wing opportunely designed according to certification specification and equipped with different powertrain architectures shows that it is worth looking into structural dynamics from preliminary design to estimate aircraft weight properly. Meanwhile, the mission analysis reveals performance benefits by implementing distributed engines all over the wingspan.