The loess region in China, known for its high seismic activity and the extreme vulnerability of loess to earthquakes, presents a considerable threat to the seismic safety of underground structures, including subway stations. With the Xi'an Aerospace City subway station as the background, a subway station model was designed, and shaking table tests were conducted under various conditions to analyze the seismic damage and dynamic responses in this study. The study reveals the seismic vulnerable areas and dynamic response patterns of the subway station under different spectral earthquake actions. Simultaneously, a three-dimensional numerical modeling analysis accounting for soil-structure interaction, was conducted to explore the displacement response of the structure and soil. Results indicate a noticeable amplification effect on the acceleration of both the structure and the soil under seismic motion. The structure exhibits a suppressive effect on the acceleration amplification of the surrounding soil, diminishing with increasing seismic motion intensity. Different depths show varying differences in acceleration responses between the structure and adjacent soil. Structural strain responses and damage phenomena suggest that the central column is the seismic vulnerable area of the subway station. Additionally, the strain distribution of the structure exhibits a distinct spatial effect. The relative horizontal displacement between the structure and the soil follows certain patterns in the depth direction, with the structure experiencing smaller relative horizontal displacement than the soil under seismic action due to the constraining effect of surrounding soil on its displacement response. The experimental conclusions provide valuable reference points for the seismic design and analysis of subway station structures in loess regions.