Strong Evidence Of Publication Bias Research Articles

How much do conservation cropping practices mitigate runoff and soil erosion under Western European conditions: A focus on conservation tillage, tied ridging and winter cover crops

AbstractConservation farming practices are known for their capacity to mitigate runoff and erosion, but the magnitude of their effectiveness is highly variable across studies. In order to better understand the contribution of environmental and management factors to their effectiveness, up to 37 studies reporting 271 individual trials were collated for a quantitative review regarding 3 common conservation agriculture‐related practices, at the plot scale and in a Western European context. Two different methods suitable for hierarchically structured data sets were used for the meta‐analyses—hierarchical nonparametric bootstrapping and linear random effects models—, yielding nearly identical average outcomes but differing in terms of confidence intervals. We found that, on average, winter cover crops reduce cumulative seasonal (autumn‐winter) runoff by 68% and soil losses by 72% compared with a bare soil. The occurrence and intensity of stubble tillage on the control plot is a key explanatory variable for the mitigation effect of winter cover crops. In potato crops, tied ridging reduces cumulative seasonal (spring–summer) runoff by a mean of 70% and soil erosion by 92%. Conservation (non‐inversion) tillage techniques alleviate cumulative seasonal overland flow by 27% and associated sediments losses by 66%, but strong evidence of publication bias was detected for this farming practice, probably leading to an overestimation of its effectiveness. These mitigation effects are shown to be much greater for spring crops than for winter crops, and to increase with time since ploughing was stopped. The type of conservation tillage scheme strongly affects the ability to attenuate surface flows. Intensive non‐inversion tillage systems relying on repeated use of (powered) tillage operations appear to be the least effective for reducing both water and sediment losses. The best performing scheme against runoff would be a deep (non‐inversion) tillage (−61%), while against erosion it would be a no‐till system (−82%). Although several explanatory factors were identified, there remains a high (unexplained) variability between trials effect sizes, thus not attributable to pure sampling variability. Meanwhile, this review provides farm advisors or policy makers with guidance on the contexts in which implementation of such conservation practices should be supported so as to maximize expected benefits.

Publication bias casts doubt on implicit processing in inattentional blindness

Two recent meta-analyses on inattentional blindness (Kreitz, Pugnaghi, & Memmert, 2020; Nobre et al., 2020) concluded that objects can be processed implicitly even when attention is directed elsewhere. However, signs of publication bias are evident in both of these meta-analyses. Here, we employed multiple tools to correct for publication bias in the data aggregated in those meta-analyses. Analyses using the Precision-Effect Test (PET) and robust Bayesian meta-analysis (RoBMA) suggest that the estimates in the original meta-analyses were inflated, together with strong evidence of publication bias. Indeed, the data are consistent with no overall implicit effects. We suggest that more evidence, particularly from well-powered pre-registered experiments, is needed before solid conclusions can be drawn regarding implicit processing during inattentional blindness.

Zinc Therapy Is a Reasonable Choice for Patients With Pressure Injuries: A Systematic Review and Meta-Analysis.

The aim of this systematic review was to summarize the evidence on the efficacy of zinc supplementation in patients with pressure injuries (PIs). Electronic data bases (Embase, MEDLINE, and Web of Science) were searched from inception to 2019 for randomized controlled trials (RCTs) and non-RCTs addressing the efficacy of zinc supplementation compared with a control nutrition invention on PI outcomes. The primary study outcome was the healing rate of PIs during treatment; the secondary outcomes were the improvement of PI area and pressure ulcer scale for healing (PUSH) score. A total of 7 studies were included in this systematic review and meta-analysis. The intervention group significantly had improved healing vs that of the control group (relative risk, 1.44; 95% CI, 1.01-2.06; P = 0.043, I2 = 19.3%). There was no obvious asymmetry in the funnel plot and no strong evidence of publication bias. Sensitivity analysis showed that meta-analysis has good stability. Studies showed a greater mean reduction in PI area. All the studies we included had a significant improvement in the PUSH score of PIs. Our systematic review and meta-analysis from clinical research confirmed that zinc therapy can promote wound healing and suggest that medical staff should consider providing patients with zinc during PI treatment.

Abstract P4-13-05: The oncological safety of autologous fat grafting after breast conserving surgery for breast cancer: A systematic review, meta- analysis and meta regression analysis of observational studies

Abstract Background: Autologous fat grafting (AFG) has been widely adopted to correct deformities resulting from breast conserving surgery (BCS) for breast cancer. However, clinical and animal studies and in vitro experiments have revealed conflicting results regarding the oncological safety of AFG. Aim: The aim of this study was to systematically evaluate the current literature regarding the oncological safety of AFG in patients who underwent BCS for breast cancer by performing a meta-analysis of observational studies. Methods: A literature research was performed using the PubMed and Embase search engines from conception until May 2019 to identify all studies of patients who underwent AFG following BCS for breast cancer. Reference lists of retrieved articles and relevant previous reviews were also searched. The primary outcome was the locoregional recurrence rate. For case-control studies a standard meta-analysis was performed to calculate a pooled relative risk (RR). For case series studies, subgroup analysis and meta-regression techniques were used with historical control data to increase reliability. Results: 26 studies reporting on 1640 BCS patients who had undergone AFG met the inclusion criteria for analysis. There were 11 case-control studies and 15 case series. For the case-controlled studies, meta-analysis using the random effects model revealed no significant difference in the locoregional recurrence rates between the AFG and control groups [RR=0.82(95% CI= 0.41-1.66)]. The mean follow up duration from surgery for the AFG group and the control group was 39 and 49 months, respectively. For the case series and historical controls, the locoregional recurrence rates were 1.85% and 2.53% respectively (p=0.33) according to subgroup and meta regression analysis. There was no strong evidence of publication bias however selection bias could not be excluded. Conclusions: Our study suggests that AFG does not increase the risk of locoregional recurrence after BCS for breast cancer. However further prospective research is needed to confirm the oncological safety of this technique particularly in patients with high risk disease. Citation Format: Salim Tayeh, Amtul R Carmichael, Humaa Darr, Zuhair Al-Fardan, Abdul Kasem, Moustapha Hamdi, Kefah Mokbel. The oncological safety of autologous fat grafting after breast conserving surgery for breast cancer: A systematic review, meta- analysis and meta regression analysis of observational studies [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P4-13-05.

Externalizing and internalizing symptoms in childhood and adolescence and the risk of alcohol use disorders in young adulthood: A meta-analysis of longitudinal studies

Evidence suggests that externalizing and internalizing symptoms are expressed early in life and are associated with problematic drinking in young adulthood. However, few studies have examined their role during childhood and adolescence in predicting alcohol problems later in life. To examine the role of childhood and adolescent externalizing and internalizing symptoms in predicting alcohol use disorders in young adulthood. We searched five electronic databases (PubMed, Scopus, PsycINFO, Web of Sciences and Embase) for studies which diagnosed alcohol use disorders through either the International Classification of Diseases or American Psychiatric Association - Diagnostic and Statistical Manual of Mental Disorders criteria and followed up children or adolescents into the transition to young adulthood. We performed a meta-analysis and obtained pooled odds ratio estimates with 95% confidence intervals using random-effects models. A total of 12 longitudinal studies met eligibility criteria and were included in the meta-analysis. All measured the outcome using Diagnostic and Statistical Manual of Mental Disorders criteria. The majority were of good quality and were conducted in the United States. A total of 19,407 participants (50% female) were included in this meta-analysis. Of these, n = 2337 (12%) had diagnoses of alcohol use disorders/alcohol dependence. Participant ages ranged from birth to 36 years. Internalizing symptoms increased the risk of young adult alcohol use disorders by 21% (odds ratio = 1.21; 95% confidence interval = [1.05, 1.39]), with no strong evidence of publication bias. Subgroup analysis suggested significantly lower heterogeneity than for externalizing studies. Externalizing symptoms increased the risk of alcohol use disorders by 62% (odds ratio = 1.62, 95% confidence interval = [1.39, 1.90]). We found some evidence of publication bias and significant heterogeneity in the studies. Our findings highlight the contribution of early behavioural problems to the development of alcohol use disorders in young adulthood and the need for timely scrutiny of and intervention on early behavioural problems.

Metformin Use and Kidney Cancer Survival Outcomes: A Systematic Review and Meta-Analysis.

Metformin has been associated with improved survival outcomes in various malignancies. However, studies in kidney cancer are conflicting. We performed a systematic review and meta-analysis to evaluate the association between metformin and kidney cancer survival. We searched Medline and EMBASE databases from inception to June 2017 to identify studies evaluating the association between metformin use and kidney cancer survival outcomes. We evaluated risk of bias with the Newcastle-Ottawa scale. We pooled hazard ratios (HRs) for recurrence-free, progression-free, cancer-specific, and overall survival using random effects models, and explored heterogeneity with metaregression. We evaluated publication bias through Begg's and Egger's tests, and the trim and fill procedure. We identified 9 studies meeting inclusion criteria, collectively involving 7426 patients. Five studies were at low risk of bias. The direction of association for metformin use was toward benefit for recurrence-free survival (HR, 0.99; 95% confidence interval [CI], 0.36-2.74), progression-free survival (pooled HR, 0.84; 95% CI, 0.66-1.07), cancer-specific (pooled HR, 0.72; 95% CI, 0.48-1.09), and overall survival (pooled HR, 0.73; 95% CI, 0.50-1.09), though none reached statistical significance. Metaregression found no study-level characteristic to be associated with the effect size, and there was no strong evidence of publication bias for any outcome. There is no evidence of a statistically significant association between metformin use and any survival outcome in kidney cancer. We discuss the potential for bias in chemoprevention studies and provide recommendations to reduce bias in future studies evaluating metformin in kidney cancer.

Meta-analysis, military expenditures and growth

This article conducts a meta-analysis of the effect of military expenditures on growth within a structured analytic framework. We extend the pioneering study of Aynur Alptekin and Paul Levine, by using a much larger sample of studies. Like them we confine our attention to studies that use the share of military expenditure in GDP, the military burden, as the independent variable, but unlike them we include not just those that use the military burden directly, what we call the core sample, but also those that use other functions of it, such as logarithms, differences, etc., which we call the remaining sample. We also consider an overall sample which pools all results. The t-statistic on the coefficient of military burden is used as the dependent variable. Our null hypothesis is that military expenditure has no significant effect on growth and we explain why this is plausible. The estimates are sensitive to the sample and type of data used, estimation method adopted, and the controls included. Overall, the results are consistent with the hypothesis of no effect: the average effect across all studies is close to zero. Certain study characteristics appear significant determinants of the effect of military expenditure on growth, but there does not appear to be a simple pattern and different characteristics were significant in the three samples. This might be a result of data mining to produce a significant result. However, there does not appear to be strong evidence of publication bias towards positive or negative results, perhaps because there is no strong a priori belief in the direction of the effect.

Treatment outcomes for anorexia nervosa: a systematic review and meta-analysis of randomized controlled trials.

To determine the impact of specialized treatments, relative to comparator treatments, upon the weight and psychological symptoms of anorexia nervosa (AN) at end-of-treatment (EOT) and follow-up. Randomized controlled trials (RCTs) between January 1980 and December 2017 that reported the effects of at least two treatments on AN were screened. Weight and psychological symptoms were analyzed separately for each study. PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed, and studies were assessed using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) criteria and Cochrane risk of bias tool. We identified 35 eligible RCTs, comprising data from 2524 patients. Meta-analyses revealed a significant treatment effect on weight outcomes at EOT [g = 0.16, 95% CI (0.05-0.28), p = 0.006], but not at follow-up [g = 0.11, 95% CI (-0.04 to 0.27), p = 0.15]. There was no significant treatment effect on psychological outcomes at either EOT [g = -0.03, 95% CI (-0.14 to 0.08), p = 0.63], or follow-up [g = -0.001, 95% CI (-0.11 to 0.11), p = 0.98]. There was no strong evidence of publication bias or significant moderator effects for illness duration, mean age, year of publication, comparator group category, or risk of bias (all p values > 0.05). Current specialized treatments are more adept than comparator interventions at imparting change in weight-based AN symptoms at EOT, but not at follow-up. Specialized treatments confer no advantage over comparator interventions in terms of psychological symptoms. Future precision treatment efforts require a specific focus on the psychological symptoms of AN.

The Publication Bias of the Chinese Real Estate Research: A Meta-Analysis

This article applies a meta-analysis to investigate the results from hedonic housing model in China. This paper investigates the publication bias and authentic empirical effect among those researches. Partial correlation coefficients between building area and house price reveal a strong evidence of publication bias and a genuine positive effect, in which, the financial crisis in 2007 will increase the effects of building area on house price. And the linear model partially account for the publication bias.

Experimental Manipulations of Personal Control do Not Increase Illusory Pattern Perception

We report seven experiments to investigate the effects of control threat manipulations on different measures of illusory pattern perception: magical thinking (Study 1–3), conspiracy beliefs (Study 4), paranormal beliefs (Study 5) and agent detection (Study 6 and 7). Overall we did not find evidence for an effect of control threat on any of our relevant dependent measures. By using Bayesian analyses we obtained positive evidence for the null-hypothesis that an experimentally induced loss of control does not affect illusory pattern perception. Finally, by re-conducting a recent meta-analysis we found strong evidence for publication bias and a relatively small effect size for control-threat manipulations. Together, these results cast doubt on the potential efficacy of experimental autobiographical recall manipulations to manipulate feelings of control.

Do stock markets react to soccer games? A meta-regression analysis

ABSTRACTThis study applies meta-regression analysis to aggregate a sample of 1126 empirical estimates of the stock market reaction to soccer matches collected from 37 primary studies. Our results indicate that winning a match is not associated with significant return effects for both national teams and individual clubs. In the case of lost matches, we find strong evidence for publication bias, i.e. negative returns are systematically overrepresented causing a biased picture of the true soccer match effect. After correcting for this bias, the mean return after losses by national teams becomes statistically insignificant and accounts for only basis points. In the case of individual clubs, the corrected impact of a loss is a significant basis points effect. In a further analysis, we identify various aspects of study design like regional differences, time period under examination and the design of empirical analysis to be responsible for the wide variation in previous study outcomes. Overall, our findings provide evidence against the hypothesis that stock markets are driven by sports sentiment in the case of national teams. Due to the existence of strong asymmetry in the returns after wins and losses of individual clubs, behavioural explanations cannot be fully ruled out.

Teacher Professional Development and Student Literacy Growth: a Systematic Review and Meta-analysis

This systematic review explores the impact of teacher professional development (PD) on student reading achievement. The first part of the literature evaluates all available existing systematic reviews and meta-analyses of PD intervention studies. No quality reviews of PD and reading specifically (distinct from ‘attainment’) were found. There was a little overlap of studies in existing reviews. The second part of the systematic review focuses on the most recent intervention studies exploring PD and student reading achievement. The results of a meta-analysis of all high-quality studies are presented in the third part of the paper. This analysis showed no strong evidence of publication bias and an effect size for PD on student literacy of g = 0.225. This effect was moderated by the number of hours of PD whereby studies with fewer than 30 h of PD was significant for student reading outcomes (g = 0.367, p .05). Following a Weight of Evidence assessment, analysis showed that nearly all high-quality articles involved shorter PD. Weight of Evidence was a significant moderator, (g = 0.408, p 0.5, n.s., for medium quality studies). Our review suggests that only high-quality studies of short teacher PD currently provide evidence of impact on student’s reading achievement.

The effectiveness of contract farming for raising income of smallholder farmers in low‐ and middle‐income countries: a systematic review

The effectiveness of contract farming for raising income of smallholder farmers in low‐ and middle‐income countries: a systematic review

Do Stock Markets React to Soccer Games? A Meta-Regression Analysis

This study applies meta-regression analysis to aggregate a sample of 1,126 empirical estimates of the stock market reaction to soccer matches collected from 37 primary studies. Our results indicate that winning a match is not associated with significant return effects for both national teams and individual clubs. In the case of lost matches, we find strong evidence for publication bias, i.e. negative returns are systematically overrepresented causing a biased picture of the true soccer match effect. After correcting for this bias, the mean return after losses by national teams becomes statistically insignificant and accounts for only -5 basis points. In the case of individual clubs, the corrected impact of a loss is a significant -39 basis points effect. In a further analysis, we identify various aspects of study design like regional differences, time period under examination, and the design of empirical analysis to be responsible for the wide variation in previous study outcomes. Overall, our findings provide evidence against the hypothesis that stock markets are driven by sports sentiment in the case of national teams. Due to the existence of strong asymmetry in the returns after wins and losses of individual clubs, behavioural explanations cannot be fully ruled out.

Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably!

Does aspirin detract from the benefits of mineralocorticoid receptor antagonists in patients with heart failure and a reduced left ventricular ejection fraction? Probably!

Re-Infection Outcomes following One- and Two-Stage Surgical Revision of Infected Hip Prosthesis: A Systematic Review and Meta-Analysis.

BackgroundThe two-stage revision strategy has been claimed as being the “gold standard” for treating prosthetic joint infection. The one-stage revision strategy remains an attractive alternative option; however, its effectiveness in comparison to the two-stage strategy remains uncertain.ObjectiveTo compare the effectiveness of one- and two-stage revision strategies in treating prosthetic hip infection, using re-infection as an outcome.DesignSystematic review and meta-analysis.Data SourcesMEDLINE, EMBASE, Web of Science, Cochrane Library, manual search of bibliographies to March 2015, and email contact with investigators.Study SelectionCohort studies (prospective or retrospective) conducted in generally unselected patients with prosthetic hip infection treated exclusively by one- or two-stage revision and with re-infection outcomes reported within two years of revision. No clinical trials were identified.Review MethodsData were extracted by two independent investigators and a consensus was reached with involvement of a third. Rates of re-infection from 38 one-stage studies (2,536 participants) and 60 two-stage studies (3,288 participants) were aggregated using random-effect models after arcsine transformation, and were grouped by study and population level characteristics.ResultsIn one-stage studies, the rate (95% confidence intervals) of re-infection was 8.2% (6.0–10.8). The corresponding re-infection rate after two-stage revision was 7.9% (6.2–9.7). Re-infection rates remained generally similar when grouped by several study and population level characteristics. There was no strong evidence of publication bias among contributing studies.ConclusionEvidence from aggregate published data suggest similar re-infection rates after one- or two-stage revision among unselected patients. More detailed analyses under a broader range of circumstances and exploration of other sources of heterogeneity will require collaborative pooling of individual participant data.Systematic Review RegistrationPROSPERO 2015: CRD42015016559

Significance testing in empirical finance: A critical review and assessment

This paper critically reviews the practice of significance testing in modern finance research. Employing a survey of recently published articles in four top-tier finance journals, we find that the conventional significance levels are exclusively used with little consideration of the key factors such as the sample size, power of the test, and expected losses. We also find that statistically significant results reported in many surveyed papers become questionable, if Bayesian method or revised standards for evidence were instead used. We observe strong evidence of publication bias in favour of statistical significance. We propose that substantial changes be made to the current practice of significance testing in finance research, in order to improve research credibility and integrity.

Significance Testing in Empirical Finance: A Critical Review and Assessment

This paper critically reviews the practice of significance testing in modern finance research. Employing a survey of recently published articles in four top-tier finance journals, we find that the conventional significance levels are exclusively used with little consideration of the key factors such as the sample size, power of the test, and expected losses. We also find that statistically significant results reported in many surveyed papers become questionable, if Bayesian method or revised standards for evidence were instead used. We observe strong evidence of publication bias in favour of statistical significance. We propose that substantial changes be made to the current practice of significance testing in finance research, in order to improve research credibility and integrity.

Mouthwash Use and the Prevention of Plaque, Gingivitis and Caries

Careful quantitative assessment of data regarding use of mouthwash and risk of common oral conditions reveals that there is a clear evidence of benefi t from use in terms of reducing the risk of dental plaque, gingivitis, dental caries and that there are no major adverse effects including no evidence of an increased risk of oral cancer among users of mouthwash containing alcohol. Despite limitations in the quality of many studies conducted, there is a signifi cant reduction of both dental plaque and gingivitis associated with use of mouthwash preparations containing chlorhexidine or essential oils as an adjunct to standard care. The effect of mouthwash containing essential oils on both plaque and gingivitis is less than chlorhexidine in studies of less than 3 months duration but improves with increasing duration of use and equals or exceeds the effect of chlorhexidine when use is 6 months of longer. Mouthwash preparations containing cetylpyridinium or triclosan may also be effective, but less than the two former, while mouthwashes containing delmopinol are not effective for plaque and gingivitis control. How- ever, there is a large degree of heterogeneity and strong evidence of publication bias: there is a lack of small studies with a small effect of mouthwash. This results in a biased estimate of effect (over-estimated) because there is a tendency to publish mainly positive studies (those showing a strong decrease). Compared with fl uoride toothpaste used alone, topical fl uorides (mouthrinses, gels or varnishes) used in addition to fl uo- ride toothpaste reduce caries by 10% on average. Topical fl uorides (mouthrinses, gels, or varnishes) used in addition to fl uo- ride toothpaste achieve a modest reduction in caries compared to toothpaste used alone. No conclusions about any adverse effects can be reached, because such data were rarely reported in the trials. It is possible to conclude that mouthwash contain- ing fl uoride is a useful adjunct to fl uoridated toothpaste in reducing caries in children. As regards oral malignancy, quantitative analysis of mouthwash use and oral malignancy revealed no statistically signifi - cant association between mouthwash use and risk of oral cancer including no signifi cant trend in risk with increasing daily use; and no association between use of mouthwash containing alcohol and oral cancer risk. Most recent estimates of the population attributable risk for alcohol consumption and oral cancer put the fi gure at 1%. The dose of acetaldehyde from mouthwash is minute compared to that from other sources notable cigarette smoking, alco- hol drinking and certain foodstuffs including yoghurt and peas. It is extremely unlikely from a theoretical viewpoint that mouthwash could be a cause of oral cancer and this is substantiated from the lack of evidence of carcinogenicity found in epidemiological studies in humans. In summary, there is evidence supporting the use of mouthwashes in terms of preventing or reducing the risk of develop- ing a number of common conditions notably dental plaque, gingivitis and dental caries without any adverse effects. There is also evidence that mouthwash use does not increase the risk of oral cancer even when it contains a signifi cant percentage of alcohol. Mouthwash use makes a signifi cant contribution to public health.

P5-13-17: Multigene Signature Assays in Patients with Early-Stage Breast Cancer (ESBC) Receiving Neoadjuvant Chemotherapy: An NCI-Funded Systematic Review and Evidence Summary of Predictive Performance.

Abstract Background: A comprehensive literature search and evidence synthesis of multigene signatures predictive of response to systemic chemotherapy in patients with breast cancer was initiated as a part of an NCI-funded program on Comparative Effectiveness Research. Methods: Validation studies were sought of multigene signatures for prediction of chemotherapy response (favorable vs unfavorable) in ESBC patient cohorts different from those used for signature development. Pooled estimates [±95% CI] of assay performance for predicting clinical outcome included sensitivity, specificity, likelihood ratio, predictive value (PV) and predictive odds ratio (POR) utilizing mixed effects models based on the method of Mantel-Haenszel. Exploratory metaregression analyses on log (POR) were also performed. Studies were classified by validation type including cell lines to patients, independent internal sample, random split sample, or external validation. Evidence for publication bias was assessed by Egger's regression intercept and Begg and Mazumdar's rank correction. Results: Dual-blind review of abstracts identified 33 studies of neoadjuvant chemotherapy response of which 29 stratified treatment response by signature classifier category. Classifier development was based on tumor response prediction in 20 studies, prognosis in 5, and molecular classification in 4. The Table shows assay performance measures overall and by study validation type. Assay performance based on the POR was positively associated with overall study quality (P=.015) and journal impact factor (P=.020). However, strong evidence for publication bias was observed based on both regression intercept (P<.001) and rank correlation (P=.005). No significant differences in assay performance were noted for assays originally developed for response prediction (POR=5.3), prognosis (POR=6.6) or molecular classification (P=6.9) (P=.770). Conclusions: While assay performance in predicting response to neoadjuvant chemotherapy based on multigene classifiers is encouraging, a compelling need exists for greater methodologic rigor and standardization of reporting. The predictive performance of multigene assay signatures varies with the type of validation sample utilized with external validation providing the most conservative estimates. No differences were seen for assays developed for prediction, prognosis or molecular classification. Considerable evidence for publication bias exists reflecting a paucity of smaller negative studies. The clinical validity of genomic response prediction assays should be evaluated in patient cohorts independent of those utilized for signature development. The clinical utility of these assays must then be further assessed in comparative effectiveness studies compared to commonly utilized clinical and laboratory measures. Funding: NCI: UC2CA14041-01 Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-13-17.