The majority of previous studies have primarily focused on the impact of nodal deviation or joint’s strong axis bending stiffness of semi-rigid single-layer reticulated shell, ignoring the effect of other kinds of joint stiffness and its interaction with joint size and nodal deviation. Therefore, the single-layer reticulated dome considering all kinds of joint stiffness and joint size is established initially. Subsequently, a comprehensive investigation is conducted to analyze the effect of all types of joint stiffness of improved bolt-column (IBC) joints, as well as joint size and nodl deviation, on the load-carrying capacity of dome. Finally, the coupling effect among these factors on the mechanical performance of dome is also determined. The main conclusions obtained are presented as follows: (I) the axial stiffness of the IBC joint significantly influences the load-carrying capacity of single-layer reticulated dome, resulting in an average decline ratio of 27 %; however, the other types of joint stiffness have a negligible impact, with an average effect of only 1 %. Moreover, the limit load of the dome considering practical stiffness of IBC joint can achieve the 61 % of that of rigid dome; (II) rigidly joined domes with nodal deviations of S/300, S/600, S/900, S/1200 and S/1500 exhibit decline ratios of 0.57, 0.47, 0.41, 0.37 and 0.34, respectively, in load-carrying capacity compared to perfect domes. Moreover, when considering the coupling effect of joint stiffness, joint size and nodal deviation on the load-carrying capacity of the domes, these nodal deviations affect the capacity by 0.65, 0.57, 0.52, 0.49 and 0.46.