The potential health risk posed by particle resuspension in the air of an airliner cabin is a concern for passengers. This study employed computational fluid dynamics (CFD) to analyze particle dispersion patterns under different ventilation systems, such as mixing ventilation (MV), underfloor air distribution (UFAD), and aisle displacement ventilation (ADV), within a twin-aisle cabin environment. To ensure the accuracy of the CFD model, the study validated the simulated air velocity distribution against experimental airflow patterns from a small-scale water model reported in existing literature. Additionally, the research included direct measurements of particle resuspension within the breathing zone of a full-scale, twin-aisle cabin mockup, which featured five rows of seats. These measurements were taken in response to the disturbance caused by a volunteer walking over an aviation carpet in the aisle. While the CFD simulation results generally aligned with the experimental data, some discrepancies were noted. Pinpointing the exact causes of these discrepancies proved challenging due to the numerous uncertainties and approximations inherent in the study. Nevertheless, the investigation revealed that the air in the upper region near the moving body was pushed forward, creating a strong airflow that enveloped the body. This dynamic resulted in the formation of a wake that lifted particles from the floor level to the upper cabin area. The study observed that particle concentration within the breathing zone increased in the direction of movement. The airflow patterns produced by the three ventilation systems were different. Despite the cabin's symmetrical design, some particles can still transfer from one side to the other, especially under the MV system. The peak particle concentration in the breathing zone was recorded at 20 s, after which it decreased to negligible levels by 120 s. Among the ventilation systems analyzed, the MV system exhibited the highest peak particle concentration, while the UFAD system showed the lowest peak. However, the UFAD system also presented the possibility of very high particle concentrations at certain seats.