The present study experimentally explored the flow boiling phenomena in mini-scale heat sinks under local heating conditions. A parallel strip fin heat sink (PSFHS) and a mini-channel heat sink (MCHS) are comparatively tested using R141b as working fluid. Nine separate spot-heaters are uniformly attached to the backside of the heat sinks to simulate the non-uniform heating condition. Thermocouples integrated in the nine heaters are used to gain the temperature profile. It can be found that the two-dimensional expansion of vapor in PSFHS improves the distribution of vapor and reduces the local vapor quality. Besides, the additional nucleation sites produced by the interrupted configuration of PSFHS generate more bubbles enhancing the local flow boiling. However, the bubbles coalesce and form slugs continuously, which would weaken the inflow of the working fluid. It is concluded that the temperature rise at the hot-spot location is significantly influenced by the structural configuration of the heat sinks. It is noted that for mini-scale heat sinks designed for hot-spot cooling, the interrupted channel configuration has a difference with the continuous channel configuration, but perhaps not significant.